Abstract
The most prevalent side effect of statins are muscle pains occurring in presence but also in absence [1] of elevated creatine phosphokinase (CK). In one patient statin-induced muscular pains improved significantly after vitamin E [2]. Thereafter, examining another patient we found for the first time a pronounced increase in 8-epi-PGF2α, disappearing after withdrawal of the respective statin. Earlier it has been reported that rhabdomyolysis is associated with an increase in isoprostane (IP) formation [3]. Therefore, we assessed the IP 8-epi-PGF2α in plasma, serum, and urine after extraction and purification using a specific immunoassay.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Sinzinger H. Does vitamin E beneficially affect muscle pains during HMG-Co-enzyme-Areductase inhibitors without CK-elevation? Atherosclerosis 2000; 149: 225–26.
Sinzinger H, Lupattelli G, Chehne F. Increased lipid peroxidation in a patient with CKelevation and muscle pain during statin therapy. Atherosclerosis 2000; in press.
Holt S, Reeder B, Wilson M, Harvey S, Morrow JD, Roberts LJ H, Moore K. Increased lipid peroxidation in patients with rhabdomyolysis. Lancet 1999; 353: 358–59.
Oguogho A, Mehrabi M, Sinzinger H. Increased plasma, serum and urinary 8-epiprostaglandin FZa in heterozygous hypercholesterolemia. Wiener klin Wochenschr 1999; 111: 113–18.
Sinzinger H. Two different types of exercise-induced muscle pain without myopathy and CK-elevation during HMG-Co-enzyme-A-reductase inhibitor treatment. Atherosclerosis 1999; 143: 459–60.
Dujovne CA. New lipid lowering drugs and new effects of old drugs. Curr Opin Lipidol 1997; 8: 362–68.
Bliznakov E, Wilkins DJ. Biochemical and clinical consequences of inhibiting coenzyme Q,0 biosynthesis by lipid-lowering HMG-CoA reductase inhibitors (statins): a critical overview. Adv Therapy 1998; 15: 218–28.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2001 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Sinzinger, H., Lupattelli, G., Chehne, F. (2001). Increased Isoprostane 8-epi-PGF2A in Statin-Induced Myopathy. In: Samuelsson, B., Paoletti, R., Folco, G.C., Granström, E., Nicosia, S. (eds) Advances in Prostaglandin and Leukotriene Research. Medical Science Symposia Series, vol 16. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-9721-0_38
Download citation
DOI: https://doi.org/10.1007/978-94-015-9721-0_38
Publisher Name: Springer, Dordrecht
Print ISBN: 978-90-481-5881-2
Online ISBN: 978-94-015-9721-0
eBook Packages: Springer Book Archive