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The Thick Filament of Vertebrate Striated Muscle

The Structure at Rest and at Work

  • Chapter
Molecular Control Mechanisms in Striated Muscle Contraction

Part of the book series: Advances in Muscle Research ((ADMR,volume 1))

  • 114 Accesses

Abstract

Contraction in mammalian skeletal muscle and cardiac muscle occurs through a sliding filament mechanism involving two sets of interdigitating filaments: the myosin containing thick filaments and the actin-containing thin filaments (Huxley and Hanson, 1954; Huxley and Niedergerke, 1954; Davies, 1963; Squire, 1981). Interaction between these filaments to produce force or shortening involves a cyclic binding of the myosin heads on the thick filament to the actin of the thin filament in the presence of calcium and ATP (Huxley, 1969; Huxley and Simmons, 1971; Brenner, 1987; Schoenberg, 1988). Both the biochemistry and mechanics of this mechanism have been extensively studied (Taylor, 1979; Cooke, 1986; Hibberd and Trentham, 1986; Goldman and Brenner, 1987; Schoenberg, 1988; Ford et al., 1977; Brenner, 1987; Brenner, 1990) in skeletal muscle, and understanding of the interaction between myosin and actin has been facilitated by recent x-ray crystallographic determinations of the structure of the S-1 subunit portion of the chicken skeletal muscle myosin head (Rayment et al., 1993) and of actin (Holmes et al., 1990a; Holmes et al., 1990b).

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  1. Department of Neurobiology & Anatomy, MCP-Hahnemann University School of Medicine, 2900 Henry Avenue, Philadelphia, PA, 19129, USA

    Rhea J. C. Levine

  2. Department of Anatomy, University of Puerto Rico, Medical Sciences Campus, San Juan, PR, 00935, USA

    Robert W. Kensler

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  1. University of Illinois at Chicago, Chicago, Illinois, USA

    R. John Solaro

  2. University of Wisconsin Medical School, Madison, Wisconsin, USA

    Richard L. Moss

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Levine, R.J.C., Kensler, R.W. (2002). The Thick Filament of Vertebrate Striated Muscle. In: Solaro, R.J., Moss, R.L. (eds) Molecular Control Mechanisms in Striated Muscle Contraction. Advances in Muscle Research, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-9926-9_3

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