Abstract
Though livers from cadavers being transplanted, more patients are waiting the grafting. Because of this shortage of the donation, artificial liver is expected. But at present, artificial livers do not satisfy the patients yet. In this study, we attempted to establish novel hepatoma cell line for better artificial liver. We have ever introduced anti-apoptosis gene into hybridoma cells and this transfection delayed cell death. Because of this prolonging culture, the transfectants produce 2 times more antibodies than wild type. For the longer-term or permanent artificial liver, we introduced bd-2, anti-apoptosis gene, to HepG2 hepatoma cell.
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© 2002 Springer Science+Business Media Dordrecht
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Terada, S. et al. (2002). Establishment of Novel Cell Line for Bioartificial Liver. In: Shirahata, S., Teruya, K., Katakura, Y. (eds) Animal Cell Technology: Basic & Applied Aspects. Animal Cell Technology: Basic & Applied Aspects, vol 12. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0728-2_36
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DOI: https://doi.org/10.1007/978-94-017-0728-2_36
Publisher Name: Springer, Dordrecht
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