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Diagnosis and Implications of Bone Marrow Micrometastases

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Barrett’s Esophagus

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Abstract

At presentation cancer is a systemic disease in the majority of patients with malignancy of the esophagus and stomach. This dissemination is represented by either isolated or microaggregates of tumor cells, which have the potential to establish overt metastases, and are not detectable by serological measurements of tumor markers or by radiological imaging. These micrometastases are present in approximately 90% of patients who are subjected to curative excisional surgery and explain the frequent early tumor recurrences after radical resection. At diagnosis, the clinico-pathological stage of primary cancer remains the best predictor of outcome and is the determinant of treatment strategy1–3. When disseminated disease is present, cure by excision of the primary is not possible unless effective adjuvant therapies are available.

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Authors
  1. Donal Maguire
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  2. Fergus Shanahan
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  3. Gerald C. O’Sullivan
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Editors and Affiliations

  1. Erasmus University Medical Centre, Rotterdam, The Netherlands

    Hugo W. Tilanus (Professor of Surgery) (Professor of Surgery)

  2. Hope Hospital, Salford, UK

    Stephen E. A. Attwood F.R.C.S. (Consultant Surgeon) (Consultant Surgeon)

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Maguire, D., Shanahan, F., O’Sullivan, G.C. (2001). Diagnosis and Implications of Bone Marrow Micrometastases. In: Tilanus, H.W., Attwood, S.E.A. (eds) Barrett’s Esophagus. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0829-6_24

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