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Intraperitoneal chemotherapy

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Textbook of Peritoneal Dialysis

Abstract

A wide variety of therapeutic drugs are administered into the peritoneal cavity as a portal of entry to the body and as a localized treatment. Because of intravenous access problems in neonates, transfusion of packed red blood cells was one of the earliest uses of intraperitoneal (i.p.) therapy [1, 2]. Insulin is often placed in the dialysate in order to treat glucose intolerance during peritoneal dialysis [3], and i.p. insulin delivery is currently undergoing investigation as a means of long-term therapy in diabetes [4]. Erythropoietin, prescribed as replacement therapy for the anaemia related to end-stage renal disease (ESRD), has recently been administered intraperitoneally [5, 6]. In contrast to these forms of i.p. therapy which are designed to treat systemic illnesses, antibacterial agents are injected intraperitoneally in order to treat peritonitis [7, 8]. In the past 20 years i.p. chemotherapy has increasingly been evaluated for treatment of malignancies localized to the peritoneal cavity [9–22].

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Authors
  1. M. F. Flessner
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  2. R. L. Dedrick
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Editor information

Editors and Affiliations

  1. Department of Renal Medicine, Manchester Royal Infirmary, Oxford Road, M13 9WL, Manchester, UK

    R. Gokal

  2. Division of Nephrology, Department of Medicine, MA 436 Health Services Centre, University of Missouri-Columbia, 65212, Columbia, MO, USA

    R. Khanna

  3. Academisch Medisch Centrum, Amsterdam, The Netherlands

    R. Th. Krediet

  4. Department of Internal Medicine, MA 436 Health Sciences Center, University of Missouri-Columbia, 65212, Columbia, MO, USA

    K. D. Nolph

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© 2000 Springer Science+Business Media Dordrecht

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Flessner, M.F., Dedrick, R.L. (2000). Intraperitoneal chemotherapy. In: Gokal, R., Khanna, R., Krediet, R.T., Nolph, K.D. (eds) Textbook of Peritoneal Dialysis. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-3225-3_28

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  • DOI: https://doi.org/10.1007/978-94-017-3225-3_28

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-017-3227-7

  • Online ISBN: 978-94-017-3225-3

  • eBook Packages: Springer Book Archive

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