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Anhedonia as an Indicator of Genetic Vulnerability to Schizophrenia

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Anhedonia: A Comprehensive Handbook Volume II

Abstract

The symptom of anhedonia has been central to causal theories of schizophrenia put forth by Rado and Meehl. Yet, the significance of anhedonia to the etiology of schizophrenia remains unclear. Anhedonia is regarded as a core symptom of schizophrenia and has been repeatedly observed in biological relatives of people with the disorder. This chapter summarizes findings for trait anhedonia being an indicator of genetic vulnerability for schizophrenia. Relevant studies of twins and families affected by schizophrenia, of the general population, and select animal models of the disorder, are reviewed. Evidence suggests that trait anhedonia may conform to the criteria for an endophenotype as defined by Gottesman and Gould (2003). Nonetheless, concerns about diagnostic specificity and variation in findings across self-report and experiment-based measurement warrant further investigation, to more fully understand how the symptom reflects genetic liability for schizophrenia.

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Abbreviations

COMT:

Catechol-O-methyltransferase gene

DISC1:

Disrupted-in-schizophrenia 1 gene

DSM:

Diagnostic and Statistical Manual of Mental Disorders

GWAS:

Genome-wide association studies

MGS:

Molecular Genetics of Schizophrenia

PGC:

Psychiatric Genome-Wide Association Study Consortia

RDoC:

Research Domain Criteria

SNP:

Single nucleotide polymorphism

SPQ:

Schizotypal Personality Questionnaire

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Acknowledgements

The authors wish to acknowledge Drs. Mark Lenzenweger and Irving Gottesman for their review and comment on the manuscript.

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Authors and Affiliations

  1. Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, USA

    Anna R. Docherty

  2. Mental and Behavioral Health, Minneapolis VA Medical Center, Departments of Psychiatry & Psychology, University of Minnesota, Minneapolis, MN, USA

    Scott R. Sponheim Ph.D.

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  1. Anna R. Docherty
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Correspondence to Anna R. Docherty .

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Editors and Affiliations

  1. Haifa & Sha'ar Menashe Mental Health Center, Israel Institute of Technology, Hadera, Israel

    Michael S. Ritsner

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Docherty, A.R., Sponheim, S.R. (2014). Anhedonia as an Indicator of Genetic Vulnerability to Schizophrenia. In: Ritsner, M. (eds) Anhedonia: A Comprehensive Handbook Volume II. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-8610-2_4

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