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TRPC Channels and Cell Proliferation

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Transient Receptor Potential Canonical Channels and Brain Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 976))

Abstract

TRPCs have been demonstrated to be widely expressed in different cancers. In recent years, a number of studies closely investigated the roles of TRPCs in cancer cells. Most of the results show that both mRNA and protein levels of TRPCs significantly increase in cancer tissues compared with healthy controls. TRPCs regulate Ca2+ homeostasis, contribute to cell cycle regulation and the expression/activation of Ca2+-related factors, and thus play critical roles in the proliferation of cancer cells. Therefore, TRPCs could act as potential drug targets for cancer diagnosis and therapy.

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Acknowledgment

This study was supported by the National Natural Science Foundation of China (Grant Nos. 81401875, 81472225) (http://www.nsfc.gov.cn/) and Natural Science Foundation of Shanghai, China (Grant No. 14ZR1406000) (http://www.stcsm.gov.cn/).

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Authors and Affiliations

  1. Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China

    Cheng Zhan & Yu Shi

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  1. Cheng Zhan
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  2. Yu Shi
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Correspondence to Yu Shi .

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Editors and Affiliations

  1. Center of Cognition and Brain Science, Institute of Basic Medical Science, Beijing, China

    Yizheng Wang

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Zhan, C., Shi, Y. (2017). TRPC Channels and Cell Proliferation. In: Wang, Y. (eds) Transient Receptor Potential Canonical Channels and Brain Diseases. Advances in Experimental Medicine and Biology, vol 976. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1088-4_13

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