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Role of Microglia in Adult Neurogenesis

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Inflammation: the Common Link in Brain Pathologies

Abstract

Microglia as resident macrophages are responsible to maintain the normal physiology and homeostasis in the central nervous system and undergo various structural changes to perform immunological functions. Microglial activation are widely implicated in both neuroprotection and neurodegeneration. Apart from its conventional neuromodulatory role, microglia are also associated with brain development, neuronal circuitry formation, neuroendocrine regulation as well as neurogenesis. In this review, we discuss critical role of microglia in regulating adult neurogenesis.

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Acknowledgments

P. Ghosh is recipient of Junior Research Fellowship (NET) from University Grants Commission. Present area of work which is under discussion in this article is now financially supported by Science & Engineering Research Board (DST), Govt of India and Indian Council of Medical Research, Govt of India.

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  1. Department of Zoology and Immunobiology Laboratory, Panihati Mahavidyalaya (West Bengal State University), Barasat Road, Sodepur, North 24 Parganas, Kolkata, 700110, West Bengal, India

    Payel Ghosh & Anirban Ghosh

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  1. Payel Ghosh
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  2. Anirban Ghosh
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Correspondence to Anirban Ghosh .

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  1. Molecular and Cellular Neuroscience, National Brain Research Centre, Gurgaon, Delhi, India

    Nihar Jana

  2. Molecular and Cellular Neuroscience, National Brain Research Centre, Gurgaon, Delhi, India

    Anirban Basu

  3. National Brain Research Centre, National Research Professor, National Brain Research Centre, Gurgaon, Delhi, India

    Prakash Narain Tandon

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Ghosh, P., Ghosh, A. (2016). Role of Microglia in Adult Neurogenesis. In: Jana, N., Basu, A., Tandon, P. (eds) Inflammation: the Common Link in Brain Pathologies. Springer, Singapore. https://doi.org/10.1007/978-981-10-1711-7_13

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