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Diagnostic Evaluation as a Biomarker in Patients with ADPKD

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Cystogenesis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 933))

Abstract

Recently, newer treatments have been introduced for autosomal dominant polycystic kidney disease (ADPKD) patients. Since cysts grow and renal function declines over a long period of time, the evaluation of treatment effects in ADPKD has been very difficult. Therefore, there has been a great interest to find out the “better” surrogate marker or biomarker which reflects disease progression. Biomarkers in ADPKD should have three clinical implications: (1) They should reflect disease severity, (2) they should distinguish patients with poor versus good prognosis to select those who will benefit better from the treatment, and (3) they should be easy to evaluate short-term outcome after treatment, which will demonstrate hard outcome. Herein, we will discuss currently available surrogate biomarkers including the volume of total kidney and urinary molecular markers.

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Authors and Affiliations

  1. Division of Nephrology, Department of Internal Medicine, The Armed Forces Capital Hospital, Seongnam-si, Gyeonggi-do, South Korea

    Hayne Cho Park

  2. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea

    Curie Ahn

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  1. Hayne Cho Park
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  2. Curie Ahn
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Correspondence to Hayne Cho Park .

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Editors and Affiliations

  1. Department of Life systems, Sookmyung Women’s University, Seoul, Korea (Republic of)

    Jong Hoon Park

  2. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea (Republic of)

    Curie Ahn

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Park, H.C., Ahn, C. (2016). Diagnostic Evaluation as a Biomarker in Patients with ADPKD. In: Park, J., Ahn, C. (eds) Cystogenesis. Advances in Experimental Medicine and Biology, vol 933. Springer, Singapore. https://doi.org/10.1007/978-981-10-2041-4_8

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