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Regulation of the Heat Shock Response in Bacteria

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Prokaryotic Chaperonins

Part of the book series: Heat Shock Proteins ((HESP,volume 11))

Abstract

Bacteria sense temperature changes in many ways and have developed different strategies to respond to these changes. A sudden increase in temperature results in protein unfolding, and the level of unfolded proteins seems to be the primary signal that triggers the heat shock response. Four different systems have been described so far involved in temperature sensing: alternative sigma factors, transcriptional repressors, and RNA and DNA thermosensors. Furthermore, titration of molecular chaperones serves as mediators in some cases. All four mechanisms will be described in detail and illustrated by prominent examples.

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  1. Institute of Genetics, University of Bayreuth, 95440, Bayreuth, Germany

    Wolfgang Schumann

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  1. Institute of Microbiology and Infection – School of Biosciences, University of Birmingham, Birmingham, West Midlands, United Kingdom

    C. M. Santosh Kumar

  2. Laboratory of Structural Biology, National Centre for Cell Science, Pune, Maharashtra, India

    Shekhar C. Mande

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Schumann, W. (2017). Regulation of the Heat Shock Response in Bacteria. In: Kumar, C., Mande, S. (eds) Prokaryotic Chaperonins. Heat Shock Proteins, vol 11. Springer, Singapore. https://doi.org/10.1007/978-981-10-4651-3_2

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