Abstract
Lipids are small hydrophobic or amphipathic molecules that may entirely or in part originate by carbanion-based condensations of thioesters and/or by carbocation-based condensations of isoprene units. Further lipids are classified along with prominent examples. The concept of lipids, their molecular shape, macromolecular assembly and packing or shape parameter—surface area, hydrophobic volume and tail length is explained. Kinetically frozen micelles, inverted micelles, and supermicelles along with bilayers—has been explained. This explanation is supported by key features of formation and application aspect as well. Liposomes, vesicles, and GUV have been explained in detail along with related application in the different sectors. The aspect of visualization of various structures using typical visualization tools has been considered. The main focus revolves around X-ray, NMR, and microscopy both confocal and electron microscopy. A section on molecular dynamic simulations, to discuss about computational approach in better understanding, is also considered. The membrane phases, their transitions, and relative curvatures have been dealt in detail. The final section involves study of the role of membrane lipids in cellular process and human health. The aspect of immunotherapy and prospects in the future are also incorporated in the end.
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Sharma, C., Arya, P.V., Singh, S. (2017). Lipid and Membrane Structures. In: Misra, G. (eds) Introduction to Biomolecular Structure and Biophysics. Springer, Singapore. https://doi.org/10.1007/978-981-10-4968-2_6
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DOI: https://doi.org/10.1007/978-981-10-4968-2_6
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