Abstract
An electrical network model is designed to represent the central dogma of molecular biology and simulate the response to study the behaviors of bacteria gene E. coli. The transcription and translation processes of a biological system are represented by differential equations. These equations are mapped into electrical domain, and an equivalent electrical circuit is realized. The electrical response of circuit is simulated in SPICE domain, and result shows the structural and repressor protein behaves like a toggle switch which truly matches with biological system.
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Acknowledgements
The authors wish to thank DST, Science and Engineering Research Board (SERB/F/4504/2013–2014), Govt. of India for funding support of research work.
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Dutta, M., Barman, S. (2018). Electrical Equivalent Model for Gene Regulatory System. In: Nath, V. (eds) Proceedings of the International Conference on Microelectronics, Computing & Communication Systems. Lecture Notes in Electrical Engineering, vol 453. Springer, Singapore. https://doi.org/10.1007/978-981-10-5565-2_14
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DOI: https://doi.org/10.1007/978-981-10-5565-2_14
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