Skip to main content
SpringerLink
Log in

Endophytes from Malaysian Medicinal Plants as Sources for Discovering Anticancer Agents

  • Chapter
  • First Online:
Medicinal Plants and Fungi: Recent Advances in Research and Development

Part of the book series: Medicinal and Aromatic Plants of the World ((MAPW,volume 4))

Abstract

Malaysia hosts a diverse range of medicinal plants having therapeutic values including anticancer properties. Over the years, a group of microorganisms called endophytes producing bioactive compounds similar to their host plants has been discovered. These endophytes, producing important compounds such as Taxol, L-asparaginase, and sclerotiorin, can be isolated and cultured in large scale to produce valuable compounds. This alternative approach of producing bioactive compounds is more sustainable than plants, as endophytes are renewable sources. In this chapter, endophytes from Malaysian medicinal plants have been discussed, highlighting the diversity of endophytes, the valuable compounds produced, the current methods used in biosourcing of endophytes, and the future prospects of anticancer agents derived from endophytes of Malaysian medicinal plants.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 259.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

A549:

Human Caucasian lung carcinoma

B16-F10:

Mouse skin melanoma

CDK:

Cyclin-dependent kinase

CEMss:

Human T4-lymphoblastoid cell line

CPT:

Camptothecin

D551:

Human normal skin cells

DLD-1:

Human colorectal adenocarcinoma

DNA:

Deoxyribonucleic acid

ELISA:

Enzyme-linked immunosorbent assay

HCT116:

Human colon carcinoma

HeLa:

Human cervix carcinoma

HepG2:

Human Caucasian hepatocyte carcinoma

HPLC:

High-performance liquid chromatography

K562:

Human chronic myeloid leukemia

Kb:

Oral carcinoma cells

LLC:

Lewis lung carcinoma

M059J:

Human brain malignant glioma

MCF-7:

Human breast adenocarcinoma

MCM-B2:

Canine mammary carcinoma

MDAMB231:

Human breast adenocarcinoma

MG63:

Human bone osteosarcoma

MS:

Mass spectrometry

MTT:

3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide

NCI-H1299:

Human lung carcinoma

NMR:

Magnetic resonance spectroscopy

NPAA:

Nonprotein amino acids

P388:

Murine leukemia cells

PBLs:

Primary blood lymphocytes

PC12:

Rat adrenal pheochromocytoma

PC3:

Human prostate adenocarcinoma

SkO-3:

Human Caucasian ovary adenocarcinoma

T-47D:

Human breast ductal carcinoma

TCM:

Traditional Chinese medicine

WEHI-3:

Mouse leukemia cells

References

  • Abdel-Wahab SI, Abdul AB, Mohan S, Al-Zubairi AS, Elhassan MM, Al-Zubairi A (2009) Oncolysis of breast, liver and leukemia cancer cells using ethyl acetate and methanol extracts of Goniothalamus umbrosus. Res J Biol Sci 4(2):209–215. doi: rjbsci.2009.209.215

    Google Scholar 

  • Ariffin SA, Davis P, Ramasamy K (2011) Cytotoxic and antimicrobial activities of Malaysian marine endophytic fungi. Bot Mar 54(1):95–100. doi:10.1515/BOT.2011.005

    Article  Google Scholar 

  • Ariffin SA, Ramasamy K, Davis P, Mani V, Abdulla MA (2014) Safety of Malaysian marine endophytic fungal extract S2 from a brown seaweed Turbinaria conoides. J Coast Life Med 2:527–534. doi:10.12980/JCLM.2.201414J18

    Google Scholar 

  • Arunachalam C, Gayathri P (2010) Studies on bioprospecting of endophytic bacteria from the medicinal plant of Andrographis paniculata for their antimicrobial activity and antibiotic susceptibility pattern. Int J Curr Pharm Res 2(4):63–68

    Google Scholar 

  • Bagalkotkar G, Sagineedu SR, Saad MS, Stanslas J (2006) Phytochemicals from Phyllanthus niruri Linn. and their pharmacological properties: a review. J Pharm Pharmacol 58(12):1559–1570. doi:10.1211/jpp.58.12.0001

    Article  CAS  PubMed  Google Scholar 

  • Bakar MFA, Teh AH, Rahmat A, Hashim N, Othman F, Fakurazi S (2006) Antiproliferative properties and antioxidant activity of various types of Strobilanthes crispus tea. Int J Cancer Res 2(2):152–158

    Article  Google Scholar 

  • Balandrin MF, Klocke J, Wurtele ES, Bollinger WH (1985) Natural plant chemicals: sources of industrial and medicinal materials. Science 228(4704):1154–1159

    Article  CAS  PubMed  Google Scholar 

  • Batugal PA, Kanniah J, Sy L, Oliver JT (2004) Medicinal plants research in Asia – volume I: the framework and project workplans. Bioversity International, p 120–125

    Google Scholar 

  • Bent S (2008) Herbal medicine in the United States: review of efficacy, safety, and regulation. J Gen Intern Med 23(6):854–859. doi:10.1007/s11606-008-0632-y

    Article  PubMed  PubMed Central  Google Scholar 

  • Benzie IF, Wachtel-Galor S (2011) Herbal medicine: biomolecular and clinical aspects, 2nd edn. CRC Press, Florida, pp 220–221

    Google Scholar 

  • Bernhoft A (2010) A brief review on bioactive compounds in plants. In: Bernhoft A (ed) Bioactive compounds in plants-benefits and risks for man and animals. Symposium held at The Norwegian Academy of Science and Letters, Oslo. November 2008

    Google Scholar 

  • Bhat R, Karim A (2010) Tongkat Ali (Eurycoma longifolia Jack): a review on its ethnobotany and pharmacological importance. Fitoterapia 81(7):669–679. doi:10.1016/j.fitote.2010.04.006

    Article  PubMed  Google Scholar 

  • Brusotti G, Cesari I, Dentamaro A, Caccialanza G, Massolini G (2014) Isolation and characterization of bioactive compounds from plant resources: the role of analysis in the ethnopharmacological approach. J Pharm Biomed 87:218–228. doi:10.1016/j.jpba.2013.03.007

    Article  CAS  Google Scholar 

  • Chakraborty S, Biswas S, Sarkar Manna J, Das S, Dey R (2011) Sol-gel derived silica-gel as a controlled delivery system of Andrographis paniculata extract and its anti-microbial efficacy. T Natl Res I Met 64(1):189–193. doi:10.1007/s12666-011-0037-1

    CAS  Google Scholar 

  • Chandra S (2012) Endophytic fungi: novel sources of anticancer lead molecules. Appl Microbiol Biotechnol 95(1):47–59. doi:10.1007/s00253-012-4128-7

    Article  CAS  PubMed  Google Scholar 

  • Chen Y-T, Yuan Q, Shan L-T, Lin M-A, Cheng D-Q, Li C-Y (2013) Antitumor activity of bacterial exopolysaccharides from the endophyte Bacillus amyloliquefaciens sp. isolated from Ophiopogon japonicus. Oncol Lett 5(6):1787–1792. doi:10.3892/ol.2013.1284

    PubMed  PubMed Central  Google Scholar 

  • Choo CY, Chan KL, Sam TW, Hitotsuyanagi Y, Takeya K (2001) The cytotoxicity and chemical constituents of the hexane fraction of Typhonium flagelliforme (Araceae). J Ethnopharmacol 77(1):129–131. doi:10.1016/S0378-8741(01)00274-4

    Article  CAS  PubMed  Google Scholar 

  • Das P, Srivastav AK (2014) Phytochemical extraction and characterization of the leaves of Andrographis paniculata for its anti-bacterial, anti-oxidant, anti-pyretic and anti-diabetic activity. Int J Res Rev Pharma Appl Sci 3(8):15176–15184. doi:10.15680/IJIRSET.2014.0308016

    Google Scholar 

  • Drew AK, Myers SP (1997) Safety issues in herbal medicine: implications for the health professions. Med J Aust 166(10):538–541

    CAS  PubMed  Google Scholar 

  • Engida AM, Kasim NS, Tsigie YA, Ismadji S, Huynh LH, Ju Y-H (2013) Extraction, identification and quantitative HPLC analysis of flavonoids from sarang semut (Myrmecodia pendans). Ind Crop Prod 41:392–396. doi:10.1016/j.indcrop.2012.04.043

    Article  CAS  Google Scholar 

  • Gangadevi V, Muthumary J (2008) Taxol, an anticancer drug produced by an endophytic fungus Bartalinia robillardoides Tassi, isolated from a medicinal plant, Aegle marmelos Correa ex Roxb. World J Microbiol Biotechnol 24(5):717. doi:10.1007/s11274-007-9530-4

    Article  CAS  Google Scholar 

  • Garinis GA, Van der Horst GT, Vijg J, Hoeijmakers JH (2008) DNA damage and aging: new-age ideas for an age-old problem. Nat Cell Biol 10(11):1241–1247. doi:10.1038/ncb1108-1241

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Geethangili M, Rao YK, Fang S-H, Tzeng Y-M (2008) Cytotoxic constituents from Andrographis paniculata induce cell cycle arrest in Jurkat cells. Phytother Res 22(10):1336–1341. doi:10.1002/ptr.2493

    Article  CAS  PubMed  Google Scholar 

  • Ghazali W, Syahirah WA, Kannan TP, Ali M, Azah N, Abdullah NA (2016) Anticancer properties of Malaysian herbs: a review. Arch Orofac Sci 11(2):19–25

    Google Scholar 

  • Greenwell M, Rahman P (2015) Medicinal plants: their use in anticancer treatment. Int J Pharma Sci Res 6(10):4103. doi:10.13040/IJPSR.0975-8232.6(10).4103-12

    CAS  Google Scholar 

  • Hallmann J, Berg G, Schulz B (2006) Isolation procedures for endophytic microorganisms. In: Schulz B, Boyle C, Thomas N (eds) Microbial root endophytes. Springer, Heidelberg, pp 299–319

    Chapter  Google Scholar 

  • Hamiyah AN, Saad AR, Nazri AM, Ramasamy K, Weber J, Iryani WW (2012) Endophytic pyrones Aspergillus sp. display anti-proliferative effect on several cancer cell lines. In: Humanities, science, and engineering research (SHUSER), 2012 IEEE symposium on. IEEE, p 1059–1062

    Google Scholar 

  • Hasanuddin K, Supriadi G, Kurnia D, Adhita D (2015) Potential of terpenoid bioactive compound isolated from Papua ant nest as an alternative ovarian cancer treatment. Open J Obstet Gynecol 5:406–411. doi:10.4236/ojog.2015.57058

    Article  Google Scholar 

  • Hazalin NA, Ramasamy K, Lim SSM, Wahab IA, Cole AL, Majeed ABA (2009) Cytotoxic and antibacterial activities of endophytic fungi isolated from plants at the National Park, Pahang, Malaysia. BMC Complement Altern Med 9(1):46. doi:10.1186/1472-6882-9-46

    Article  PubMed  PubMed Central  Google Scholar 

  • Hazalin NAMN, Ramasamy K, Lim SM, Cole AL, Majeed ABA (2012) Induction of apoptosis against cancer cell lines by four ascomycetes (endophytes) from Malaysian rainforest. Phytomedicine 19(7):609–617. doi:10.1016/j.phymed:2012.01.007

    Article  PubMed  Google Scholar 

  • Hertiani T, Sasmito E, Sumardi, Ulfah M (2010) Preliminary study on immunomodulatory effect of sarang-semut tubers Myrmecodia tuberosa and Myrmecodia pendans. Online J Biol Sci 10(3):136–141. doi:10.3844/ojbsci.2010.136.141

    Article  Google Scholar 

  • Horwitz SB (1992) Mechanism of action of taxol. Trends Pharmacol Sci Trends 13:134–136. doi:10.1016/0165-6147(92)90048-B

    Article  CAS  Google Scholar 

  • Hsiang Y-H, Lihou MG, Liu LF (1989) Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin. Cancer Res 49(18):5077–5082

    CAS  PubMed  Google Scholar 

  • Hsieh PW, Hsu LC, Lai CH, Wu CC, Hwang TL, Lin YK, Wu YC (2009) Evaluation of the bioactivities of extracts of endophytes isolated from Taiwanese herbal plants. World J Microbiol Biotechnol 25(8):1461–1469. doi:10.1007/s11274-009-0036-0

    Article  Google Scholar 

  • Jada SR, Subur GS, Matthews C, Hamzah AS, Lajis NH, Saad MS, Stevens MFG, Stanslas J (2007) Semisynthesis and in vitro anticancer activities of andrographolide analogues. Phytochemistry 68(6):904–912. doi:10.1016/j.phytochem.2006.11.031

    Article  CAS  PubMed  Google Scholar 

  • Jinfeng EC, Rafi MIM, Hoon KC, Lian HK, Kqueen CY (2017) Analysis of chemical constituents, antimicrobial and anticancer activities of dichloromethane extracts of Sordariomycetes sp. endophytic fungi isolated from Strobilanthes crispus. World J Microbiol Biotechnol 33(1):5. doi:10.1007/s11274-016-2175-4

    Article  PubMed  Google Scholar 

  • Jordan MA, Thrower D, Wilson L (1991) Mechanism of inhibition of cell proliferation by vinca alkaloids. Cancer Res 51(8):2212–2222

    CAS  PubMed  Google Scholar 

  • Joseph B, Priya RM (2011) Bioactive compounds from endophytes and their potential in pharmaceutical effect: a review. Am J Biochem Mol Biol 1(3):291–309. doi:10.3923/ajbmb.2011.291.309

    Article  Google Scholar 

  • Kandasamy P, Manogaran S, Dhakshinamoorthy M, Kannan KP (2015) Evaluation of antioxidant and antibacterial activities of endophytic fungi isolated from Bauhinia racemosa Lam and Phyllanthus amarus Schum and Thonn. J Chem Pharm Res 7(9):366–379

    CAS  Google Scholar 

  • Kardono L, Angerhofer CK, Tsauri S, Padmawinata K, Pezzuto JM, Kinghorn AD (1990) Cytotoxic and antimalarial constituents of the roots of Eurycoma longifolia. J Nat Prod 54(5):1360–1367

    Article  Google Scholar 

  • Kharwar RN, Mishra A, Gond SK, Stierle A, Stierle D (2011) Anticancer compounds derived from fungal endophytes: their importance and future challenges. Nat Prod Rep 28(7):1208–1228. doi:10.1039/C1NP00008J

    Article  CAS  PubMed  Google Scholar 

  • Koay YC, Wong KC, Osman H, Eldeen I, Asmawi MZ (2013) Chemical constituents and biological activities of Strobilanthes crispus L. Rec Nat Prod 7(1):59–64

    CAS  Google Scholar 

  • Kumar RA, Sridevi K, Kumar NV, Nanduri S, Rajagopal S (2004) Anticancer and immunostimulatory compounds from Andrographis paniculata. J Ethnopharmacol 92(2):291–295. doi:10.1016/j.jep.2004.03.004

    Article  CAS  PubMed  Google Scholar 

  • Kuo P-C, Shi L-S, Damu AG, Su C-R, Huang C-H, Ke C-H, Wu J-B, Lin A-J, Bastow KF, Lee K-H (2003) Cytotoxic and antimalarial β-carboline alkaloids from the roots of Eurycoma longifolia. J Nat Prod 66(10):1324–1327. doi:10.1021/np030277n

    Article  CAS  PubMed  Google Scholar 

  • Kusari S, Zühlke S, Spiteller M (2009) An endophytic fungus from Camptotheca acuminata that produces camptothecin and analogues. J Nat Prod 72(1):2–7. doi:10.1021/np800455b

    Article  CAS  PubMed  Google Scholar 

  • Kusari S, Hertweck C, Spiteller M (2012) Chemical ecology of endophytic fungi: origins of secondary metabolites. Chem Biol 19(7):792–798. doi:10.1016/j.chembiol.2012.06.004

    Article  CAS  PubMed  Google Scholar 

  • Lai C-S, Mas RHMH, Nair NK, Mansor SM, Navaratnam V (2010) Chemical constituents and in vitro anticancer activity of Typhonium flagelliforme (Araceae). J Ethnopharmacol 127(2):486–494. doi:10.1016/j.jep.2009.10.009

    Article  CAS  PubMed  Google Scholar 

  • Lee ATC, Azimahtol HLP, Tan AN (2003) Styrylpyrone derivative (SPD) induces apoptosis in a caspase-7-dependent manner in the human breast cancer cell line MCF-7. Cancer Cell Int 3(1):16. doi:10.1186/1475-2867-3-16

    Article  PubMed  PubMed Central  Google Scholar 

  • Lee Y-C, Lin H-H, Hsu C-H, Wang C-J, Chiang T-A, Chen J-H (2010) Inhibitory effects of andrographolide on migration and invasion in human non-small cell lung cancer A549 cells via down-regulation of PI3K/Akt signaling pathway. Eur J Pharmacol 632(1–3):23–32. doi:10.1016/j.ejphar.2010.01.009

    Article  CAS  PubMed  Google Scholar 

  • Lin K-W (2005) Ethnobotanical study of medicinal plants used by the Jah Hut peoples in Malaysia. Indian J Med Sci 59(4):156–159

    Article  CAS  PubMed  Google Scholar 

  • Lin CH, Lee WL, Shyur LF (2012) An overview of the current development of phytoremedies for breast cancer. In: Materia Medica for various cancers. Springer, Heidelberg, p 47–67

    Google Scholar 

  • Ling LJ, Lei L, Feng L, He N, Ding L (2014) Isolation and identification of endophytic bacterium TG116 from Typhonium giganteum and its antimicrobial characteristics. J Northwest Univ Nat Sci 5:019

    Google Scholar 

  • Liu J, Luo J, Ye H, Zeng X (2012) Preparation, antioxidant and antitumor activities in vitro of different derivatives of levan from endophytic bacterium Paenibacillus polymyxa EJS-3. Food Chem Toxicol 50(3–4):767–772. doi:10.1016/j.fct.2011.11.016

    Article  CAS  PubMed  Google Scholar 

  • Madhuri S, Pandey G (2009) Some anticancer medicinal plants of foreign origin. Curr Sci India 96(6):779–783

    CAS  Google Scholar 

  • Mills JJ, Chari RS, Boyer IJ, Gould MN, Jirtle RL (1995) Induction of apoptosis in liver tumors by the monoterpene perillyl alcohol. Cancer Res 55(5):979–983

    CAS  PubMed  Google Scholar 

  • Mohan S, Abdul AB, Abdelwahab SI, Al-Zubairi AS, Aspollah Sukari M, Abdullah R, Taha MME, Beng NK, Isa NM (2010) Typhonium flagelliforme inhibits the proliferation of murine leukemia WEHI-3 cells in vitro and induces apoptosis in vivo. Leuk Res 34(11):1483–1492. doi:10.1016/j.leukres.2010.04.023

    Article  PubMed  Google Scholar 

  • Mohan S, Bustamam A, Ibrahim S, Al-Zubairi AS, Aspollah M, Abdullah R, Elhassan MM (2011) In vitro ultramorphological assessment of apoptosis on CEMss induced by linoleic acid-rich fraction from Typhonium flagelliforme Tuber. J Evid Based Complement Alternat Med 2011:12. doi:10.1093/ecam/neq010

    Google Scholar 

  • Muslim N, Ng K, Itam A, Nassar Z, Ismail Z, Majid A (2010) Evaluation of cytotoxic, anti-angiogenic and antioxidant properties of standardized extracts of Strobilanthes crispus leaves. Int J Pharm 6(5):591–599. doi:10.3923/ijp.2010.591.599

    Article  CAS  Google Scholar 

  • Nasir NNNM, Khandaker MM, Mat N (2015) Bioactive compound and therapeutic value of the some Malaysia medicinal plants: a review. J Agron 14(4):319. doi:10.3923/ja.2015.319.330

    Article  Google Scholar 

  • Pandey G, Madhuri S (2009) Some medicinal plants as natural anticancer agents. Phcog Rev 3(6):259–263

    Google Scholar 

  • Petrini O (1991) Fungal endophytes of tree leaves. In: Andrews JH, Hirano SS (eds) Microbial ecology of leaves, Brock/Springer Series in Contemporary Bioscience. Springer, New York, pp 179–197

    Chapter  Google Scholar 

  • Petrovska BB (2012) Historical review of medicinal plants’ usage. Phcog Rev 6(11):1. doi:10.4103/0973-7847.95849

    Article  Google Scholar 

  • Prakash O, Kumar A, Kumar P, Ajeet A (2013) Anticancer potential of plants and natural products: a review. Am J Pharmacol Sci 1(6):104–115. doi:10.12691/ajps-1-6-1

    Google Scholar 

  • Puri SC, Verma V, Amna T, Qazi GN, Spiteller M (2005) An endophytic fungus from Nothapodytes foetida that produces camptothecin. J Nat Prod 68(12):1717–1719. doi:10.1021/np0502802

    Article  CAS  PubMed  Google Scholar 

  • Radu S, Kqueen CY (2002) Preliminary screening of endophytic fungi from medicinal plants in Malaysia for antimicrobial and antitumor activity. Malays J Med Sci 9(2):23–33

    PubMed  PubMed Central  Google Scholar 

  • Rajagopal S, Kumar RA, Deevi DS, Satyanarayana C, Rajagopalan R (2003) Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata. J Exp Ther Oncol 3(3):147–158. doi:10.1046/j.1359-4117.2003.01090.x

    Article  CAS  PubMed  Google Scholar 

  • Ramasamy K, Lim SM, Bakar HA, Ismail N, Ismail MS, Ali MF, Faizal Weber JF, Cole AL (2010) Antimicrobial and cytotoxic activities of Malaysian endophytes. Phytother Res 24(5):640–643. doi:10.1002/ptr.2891

    Article  PubMed  Google Scholar 

  • Rao A (2010) How many medicinal plant species in Malay Peninsula? J Trop Med Plants 11(1):13–26

    Google Scholar 

  • Raviraja NS (2005) Fungal endophytes in five medicinal plant species from Kudremukh Range, Western Ghats of India. J Basic Microbiol 45(3):230–235. doi:10.1002/jobm.200410514

    Article  CAS  PubMed  Google Scholar 

  • Santiago C, Fitchett C, Munro MH, Jalil J, Santhanam J (2012) Cytotoxic and antifungal activities of 5-hydroxyramulosin, a compound produced by an endophytic fungus isolated from Cinnamomum mollissimum. J Evid Based Complement Alternat Med 2012:1–6. doi:10.1155/2012/689310

    Article  Google Scholar 

  • Saraswaty V, Srikandace Y, Simbiyani N, Setiyanto H, Udin Z (2013) Antioxidant activity and total phenolic content of endophytic fungus Fennellia nivea NRRL 5504. Pak J Biol Sci 16(22):1574. doi:10.3923/pjbs.2013.1574.1578

    Article  PubMed  Google Scholar 

  • Sharma P, Parmar J, Verma P, Sharma P, Goyal P (2009) Anti-tumor activity of Phyllanthus niruri (a medicinal plant) on chemical-induced skin carcinogenesis in mice. Asian Pac J Cancer Prev 10(6):1089–1094

    PubMed  Google Scholar 

  • Shweta S, Bindu JH, Raghu J, Suma HK, Manjunatha BL, Kumara PM, Ravikanth G, Nataraja KN, Ganeshaiah KN, Uma Shaanker R (2013) Isolation of endophytic bacteria producing the anti-cancer alkaloid camptothecin from Miquelia dentata Bedd. (Icacinaceae). Phytomedicine 20(10):913–917. doi:10.1016/j.phymed.2013.04.004

    Article  CAS  PubMed  Google Scholar 

  • Soeksmanto A, Subroto M, Wijaya H, Simanjuntak P (2010) Anticancer activity test for extracts of Sarang semut plant (Myrmecodya pendens) to HeLa and MCM-B2 cells. Pak J Biol Sci 13(3):148–151. doi:10.3923/pjbs.2010.148.15

    Article  CAS  PubMed  Google Scholar 

  • Strobel GA (2003) Endophytes as sources of bioactive products. Microbes Infect 5(6):535–544. doi:10.1016/S1286-4579(03)00073-X

    Article  CAS  PubMed  Google Scholar 

  • Strobel G, Daisy B, Castillo U, Harper J (2004) Natural products from endophytic microorganisms. J Nat Prod 67(2):257–268. doi:10.1021/np030397v

    Article  CAS  PubMed  Google Scholar 

  • Taechowisan T, Lu C, Shen Y, Lumyong S (2007) Antitumor activity of 4-Arylcoumarins from endophytic Streptomyces aureofaciens CMUAc130. J Cancer Res Ther 3(2):86–91. doi:10.4103/0973-1482.34685

    Article  CAS  PubMed  Google Scholar 

  • Tan RX, Zou WX (2001) Endophytes: a rich source of functional metabolites. Nat Prod Rep 18(4):448–459. doi:10.1039/b1009180

    Article  CAS  PubMed  Google Scholar 

  • Tang Y, Lee S, Sekaran S (2014) Phyllanthus sp. A local plant with multiple medicinal properties. J Health Transl Med. 2014 17(2):4–6

    Google Scholar 

  • Tantithanaporn S, Wattanapiromsakul C, Itharat A, Keawpradub N (2011) Cytotoxic activity of acetogenins and styryl lactones isolated from Goniothalamus undulatus Ridl. root extracts against a lung cancer cell line (COR-L23). Phytomedicine 18(6):486–490. doi:10.1016/j.phymed.2010.10.010

    Article  CAS  PubMed  Google Scholar 

  • Tarman K (2015) Fraksinasi Senyawa Antimikroba Kapang Endofit Dari Tumbuhan Pesisir Sarang Semut (Hydnophytum Formicarum). Dissertation, Bogor Agricultural University (IPB)

    Google Scholar 

  • Tee TT, Azimahtol HLP (2005) Induction of apoptosis by Eurycoma longifolia Jack extracts. Anticancer Res 25(3B):2205–2213

    PubMed  Google Scholar 

  • Tee TT, Cheah YH, Hawariah LPA (2007) F16, a fraction from Eurycoma longifolia jack extract, induces apoptosis via a caspase-9-independent manner in MCF-7 cells. Anticancer Res 27(5A):3425–3430

    PubMed  Google Scholar 

  • Ting ASY (2014) Biosourcing endophytes as biocontrol agents of wilt diseases. In: Verma V, Gange A (eds) Advances in endophytic research. Springer, India, pp 283–300

    Chapter  Google Scholar 

  • Umadevi M, Sampath K, Bhowmi D, Duraivel S (2013) Traditionally used anticancer herbs in India. J Med Plants Stud 1(3):56–74

    Google Scholar 

  • Wang Y, Dai C-C (2011) Endophytes: a potential resource for biosynthesis, biotransformation, and biodegradation. Ann Microbiol 61(2):207–215. doi:10.1007/s13213-010-0120-6

    Article  CAS  Google Scholar 

  • Wasman S, Mahmood A, Chua LS, Alshawsh MA, Hamdan S (2011) Antioxidant and gastroprotective activities of Andrographis paniculata (Hempedu Bumi) in Sprague Dawley rats. Indian J Exp Biol 49(10):767–772

    CAS  PubMed  Google Scholar 

  • Weaver BA (2014) How taxol/paclitaxel kills cancer cells. Mol Biol Cell 25(18):2677–2681. doi:10.1091/mbc.E14-04-0916

    Article  PubMed  PubMed Central  Google Scholar 

  • Wiart C (2007) Goniothalamus species: a source of drugs for the treatment of cancers and bacterial infections? J Evid Based Complement Alternat 4(3):299–311. doi:10.1093/ecam/nem009

    Article  Google Scholar 

  • Wink M (2010) Introduction: biochemistry, physiology and ecological functions of secondary metabolites. In: Wink M (ed) Annual plant reviews volume 40: biochemistry of plant secondary metabolism, 2nd edn. Wiley-Blackwell, Oxford, pp 1–19. doi:10.1002/9781444320503.ch1

    Chapter  Google Scholar 

  • Wiyakrutta S, Sriubolmas N, Panphut W, Thongon N, Danwisetkanjana K, Ruangrungsi N, Meevootisom V (2004) Endophytic fungi with anti-microbial, anti-cancer and anti-malarial activities isolated from Thai medicinal plants. World J Microbiol Biotechnol 20(3):265–272. doi:10.1023/B:WIBI.0000023832.27679.a8

    Article  Google Scholar 

  • Xu F, Tao W, Cheng L, Guo L (2006) Strain improvement and optimization of the media of taxol-producing fungus Fusarium maire. Biochem Eng J 31(1):67–73. doi:10.1016/j.bej.2006.05.024

    Article  CAS  Google Scholar 

  • Yaacob NS, Hamzah N, Kamal NNNM, Abidin SAZ, Lai CS, Navaratnam V, Norazmi MN (2010) Anticancer activity of a sub-fraction of dichloromethane extract of Strobilanthes crispus on human breast and prostate cancer cells in vitro. BMC Complement Altern Med 10(1):42. doi:10.1186/1472-6882-10-42

    Article  PubMed  PubMed Central  Google Scholar 

  • Yuletnawati SE, Meiyanto E, Agustina D (2016) High antitumor activity of ethanolic extracts of Papua’s ant nest plant (Myrmecodia tuberosa) on an oral carcinoma (KB) cell line. IJSR 5(1):1619–1622

    Article  Google Scholar 

  • Zhou J, Zhang S, Choon-Nam O, Shen HM (2006) Critical role of pro-apoptotic Bcl-2 family members in andrographolide-induced apoptosis in human cancer cells. Biochem Pharmacol 72(2):132–144. doi:10.1016/j.bcp.2006.04.019

    Article  CAS  PubMed  Google Scholar 

  • Zhou J, Ong CN, Hur GM, Shen HM (2010) Inhibition of the JAK-STAT3 pathway by andrographolide enhances chemosensitivity of cancer cells to doxorubicin. Biochem Pharmacol 79(9):1242–1250. doi:10.1016/j.bcp.2009.12.014

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. School of Science, Monash University Malaysia, Jalan Lagoon Selatan, 47500, Bandar Sunway, Selangor Darul Ehsan, Malaysia

    Ling-Sze Yap, Wai-Leng Lee & Adeline-Su-Yien Ting

Authors
  1. Ling-Sze Yap
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Wai-Leng Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Adeline-Su-Yien Ting
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Adeline-Su-Yien Ting .

Editor information

Editors and Affiliations

  1. Department of Applied Chemistry, Chaoyang University of Technology, Taichung, Taiwan

    Dinesh Chandra Agrawal

  2. Department of Applied Chemistry, Chaoyang University of Technology, Taichung, Taiwan

    Hsin-Sheng Tsay

  3. Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan

    Lie-Fen Shyur

  4. Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan

    Yang-Chang Wu

  5. Department of Forestry, National Chung Hsing University, Taichung, Taiwan

    Sheng-Yang Wang

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Yap, LS., Lee, WL., Ting, ASY. (2017). Endophytes from Malaysian Medicinal Plants as Sources for Discovering Anticancer Agents. In: Agrawal, D., Tsay, HS., Shyur, LF., Wu, YC., Wang, SY. (eds) Medicinal Plants and Fungi: Recent Advances in Research and Development. Medicinal and Aromatic Plants of the World, vol 4. Springer, Singapore. https://doi.org/10.1007/978-981-10-5978-0_10

Download citation

Publish with us

Policies and ethics

Search

Navigation