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Introduction

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Development of Chemistry-Based Screening Platform for Access to Mirror-Image Library of Natural Products

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Abstract

Natural products and their derivatives are valuable resources for drug discovery. While most of chiral natural products are produced as single enantiomeric form in nature, mirror-image isomers of them are also potential resources for drug discovery because they have identical physicochemical properties and different biological properties. To screen the mirror-image library of chiral natural products, mirror-image screening strategy has been developed. In this strategy, the screening of chiral natural products using a chemically synthesized d-protein corresponds to that of mirror-image natural products using a native protein (l-protein) in a mirror. In an effort to identify anticancer agents from the mirror-image natural products, chemical protein syntheses of some target oncoproteins, MDM2, MDMX and Grb2, and their applications to the chemical array screening process were achieved.

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Authors and Affiliations

  1. Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-shimo-adachi-cho Sakyo-ku, Kyoto, 606-8501, Japan

    Taro Noguchi

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  1. Taro Noguchi
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Correspondence to Taro Noguchi .

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Noguchi, T. (2018). Introduction. In: Development of Chemistry-Based Screening Platform for Access to Mirror-Image Library of Natural Products. Springer Theses. Springer, Singapore. https://doi.org/10.1007/978-981-10-6623-8_1

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