Abstract
This work was motivated by the need to design and de-risk a very large study evaluating safety and efficacy of an experimental vaccine designed to prevent post-operative invasive infections with Staphylococcus aureus (S aureus). S aureus is a leading cause of healthcare-associated infections, resulting in a substantial burden to health care systems.
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Joseph Severs Deepthi Jayawardene, Yahong Peng, Scott Patterson, Neal Thomas, Qin Jiang, Christy Chuang-Stein.
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Perevozskaya, I. (2018). Adaptive Group-Sequential Multi-regional Outcome Studies in Vaccines. In: Peace, K., Chen, DG., Menon, S. (eds) Biopharmaceutical Applied Statistics Symposium . ICSA Book Series in Statistics. Springer, Singapore. https://doi.org/10.1007/978-981-10-7829-3_12
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