Abstract
An efficient, convenient and environmentally benign procedure for the construction of various bioactive spirooxindoles has been developed by condensation reactions of isatins, malononitrile and α-methylene carbonyl compounds/enols in the presence of starch solution as expedient, eco-friendly and biodegradable catalyst at 60 °C. The prominent features of the above protocol are short reaction time, high atom economy, simple work-up, cost-effectiveness, avoidance of toxic chemicals.
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Acknowledgements
P.S. and G.K. are thankful to UGC and, CSIR, New Delhi respectively, for the grant of junior and senior research fellowship.
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Chaudhary, A., Saluja, P., Khanna, G. (2018). Expedient Synthesis of Diverse Spirooxindoles via Multicomponent Approach in Presence of Green Catalyst. In: Parmar, V., Malhotra, P., Mathur, D. (eds) Green Chemistry in Environmental Sustainability and Chemical Education. Springer, Singapore. https://doi.org/10.1007/978-981-10-8390-7_2
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