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Plant-Derived Compounds in Cancer Therapy: Traditions of Past and Drugs of Future

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Anticancer plants: Properties and Application

Abstract

Cancer continues to escalate as a leading public health problem. Despite numerous efforts and major advancements made to control cancer diseases, significant deficiencies and gaps for its improvement still remains. Plant is of particular interest because, its derived compounds modulate the oxidative stress and thus, affect cancer cell development by altering gene and protein expression. Emerging research evidences suggest that plant-derived compounds may possess beneficial effects against several types of cancers, such as cervical, colon, skin melanoma, breast, prostate, and leukemia cancers. This chemopreventive potential has been associated with the plant-based anticancer molecules present, such as vinca alkaloids and its semisynthetic analogues, curcumin, colchicine, epigallocatechin-3-gallate (EGCG), betulinic acid, and podophyllotoxin derivatives that have been isolated from plants, and most of them have been altered to provide better analogues in terms of solubility, toxicity, and activity. Of particular interest in this chapter, we will highlight on the emerging role of plant-derived compounds and its anticancer activities. We also provide a cohesive representation of the literature on the underlying mode of action involved in the pharmacological effects of these phytochemicals.

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Authors and Affiliations

  1. Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

    Bee Ling Tan & Mohd Esa Norhaizan

  2. Research Centre of Excellent, Nutrition and Non-Communicable Diseases, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

    Mohd Esa Norhaizan

  3. Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

    Mohd Esa Norhaizan

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  1. Bee Ling Tan
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Correspondence to Mohd Esa Norhaizan .

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  1. Department of Botany, Gandhi Faiz-e-Aam College, Shahjahanpur, Uttar Pradesh, India

    Mohd Sayeed Akhtar

  2. Department of Crop Science Faculty of Agriculture, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

    Mallappa Kumara Swamy

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Tan, B.L., Norhaizan, M.E. (2018). Plant-Derived Compounds in Cancer Therapy: Traditions of Past and Drugs of Future. In: Akhtar, M., Swamy, M. (eds) Anticancer plants: Properties and Application. Springer, Singapore. https://doi.org/10.1007/978-981-10-8548-2_5

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