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References

  • Almeida JC, Grimsley EW. Coma from the health food store: interaction between kava and alprazolam. Ann Intern Med. 1996;125:940–1.

    Article  CAS  PubMed  Google Scholar 

  • Balick MJ, Roberta L. Traditional use of sakau (kava) in Pohnpei: lessons for integrative medicine. Alter Thera. 2000;8:96.

    Google Scholar 

  • Bilia AR, Gallon S, Vincieri FF. Kava-kava and anxiety: growing knowledge about the efficacy and safety. Life Sci. 2002;70:2581–97.

    Article  CAS  PubMed  Google Scholar 

  • Boerner RJ, Sommer H, Berger W, Kuhn U, Schmidt U, Mannel M. Kava-kava extract LI 150 is as effective as Opipramol and Buspirone in generalised anxiety disorder--an 8-week randomized, double-blind multi-centre clinical trial in 129 out-patients. Phytomedicine. 2003;10(Suppl 4):38–49.

    Article  PubMed  Google Scholar 

  • Cagnacci A, Arangino S, Renzi A, Zanni AL, Malmusi S, Volpe A. Kava-Kava administration reduces anxiety in perimenopausal women. Maturitas. 2003;44:103–9.

    Article  PubMed  Google Scholar 

  • Chua HC, Christensen ET, Hoestgaard-Jensen K, Hartiadi LY, Ramzan I, Jensen AA, Absalom NL, Chebib M. Kavain, the major constituent of the anxiolytic kava extract, potentiates GABAA receptors: functional characteristics and molecular mechanism. PLoS One. 2016;11:e0157700.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Connor KM, Payne V, Davidson JR. Kava in generalized anxiety disorder: three placebo-controlled trials. Int Clin Psychopharmacol. 2006;21:249–53.

    Article  PubMed  Google Scholar 

  • De Leo V, La Marca A, Lanzetta D, Palazzi S, Torricelli M, Facchini C, Morgante G. Assessment of the association of Kava-Kava extract and hormone replacement therapy in the treatment of postmenopause anxiety. Minerva Ginecol. 2000;52:263–7.

    PubMed  Google Scholar 

  • Dentali SJ. Herb safety review. Kava. Piper methysticum Forster f. (Piperaceae). Boulder: Herb Research Foundation, 1997;29 pp.

    Google Scholar 

  • Dragull K, Yoshida WY, Tang CS. Piperidine alkaloids from Piper methysticum. Phytochemistry. 2003;63:193–8.

    Article  CAS  PubMed  Google Scholar 

  • Feltenstein MW, Lambdin LC, Ganzera M, Ranjith H, Dharmaratne W, Nanayakkara NP, Khan IA, Sufka KJ. Anxiolytic properties of Piper methysticum extract samples and fractions in the chick social-separation-stress procedure. Phytother Res. 2003;17:210–6.

    Article  PubMed  Google Scholar 

  • Furgiele AR, Farnsworth NR, Buckley JP. False-positive alkaloid reactions obtained with extracts of Piper methysticum. J Pharm Sci. 1962;51:1156–62.

    Article  Google Scholar 

  • Garner LF, Klinger JD. Some visual effects caused by the beverage kava. J Ethnopharmacol. 1985;13:307–11.

    Article  CAS  PubMed  Google Scholar 

  • Garrett KM, Basmadjian G, Khan IA, Schaneberg BT, Seale TW. Extracts of kava (Piper methysticum) induce acute anxiolytic-like behavioral changes in mice. Psychopharmacology. 2003;170:33–41.

    Article  CAS  PubMed  Google Scholar 

  • Geier FP, Konstantinowicz T. Kava treatment in patients with anxiety. Phytother Res. 2004;18:297–300.

    Article  CAS  PubMed  Google Scholar 

  • Grunze H, Langosch J, Schirrmacher K, Bingmann D, Von Wegerer J, Walden J. Kava pyrones exert effects on neuronal transmission and transmembraneous cation currents similar to established mood stabilizers-a review. Prog Neuro-Psychopharmacol Biol Psychiatr. 2001;25:1555–70.

    Article  CAS  Google Scholar 

  • Holmes LD. Piper methysticium (kava). The function of kava in modern Samoan culture. Psychopharmacol Bull. 1967;4:9.

    PubMed  CAS  Google Scholar 

  • Kinder C, Cupp MJ. Kava: an herbal sedative. Nurse Pract. 1998;14(156):23.

    Google Scholar 

  • Kinzler E, Krömer J, Lehmann E. Effect of a special kava extract in patients with anxiety-, tension, and excitation states of non-psychotic genesis. Double blind study with placebos over 4 weeks. Arzneimittelforschung. 1991;41:584–8.

    PubMed  CAS  Google Scholar 

  • Klohs MW, Keller F, Willimas RE, et al. A chemical and pharmacological investigation of Piper methysticum Forst. J Medication Pharm Chem. 1959;1:95–103.

    Article  CAS  Google Scholar 

  • Kretschmer W. Kavain as a psychopharmacologic agent. Munch Med Wochenschr. 1970;112:154–8.

    PubMed  CAS  Google Scholar 

  • Kretschmer W. Mental effects of kavain. MMW Munch Med Wochenschr. 1974;116:741–2.

    PubMed  CAS  Google Scholar 

  • Lebot V, Merlin M, Lindstrom L. Kava: The Pacific drug. New Haven: Yale University Press, 1992.; 255 pp.

    Google Scholar 

  • Lehmann E, Kinzler E, Friedemann J. Efficacy of a special Kava extract (Piper methysticum) in patients with states of anxiety, tension and excitedness of non-mental origin – a double-blind placebo-controlled study of four weeks treatment. Phytomedicine. 1996;3:113–9.

    Article  CAS  PubMed  Google Scholar 

  • Lehrl S. Clinical efficacy of kava extracts WS 1490 in sleep disturbances associated with anxiety disorders. Results of a multicenter, randomized, placebo-controlled, double-blind clinical trial. J Affect Disord. 2004;78:101–10.

    Article  PubMed  Google Scholar 

  • Lemert EM. Secular use of kava in Tonga. Q J Stud Alcohol. 1967;28:328–41.

    PubMed  CAS  Google Scholar 

  • Lemert EM. Koni, kona, kava. Orange-beer culture of the Cook Islands. J Stud Alcohol. 1976;37:565–85.

    Article  CAS  PubMed  Google Scholar 

  • Lindenberg D, Pitule-Schödel H. D,L-kavain in comparison with oxazepam in anxiety disorders. A double-blind study of clinical effectiveness. Fortschr Med 1990;108:49–50., 53-4.

    Google Scholar 

  • Meyer HJ. A study of anticonvulsant properties of the kava pyrones dihydromethysticin and dihydrokavain in chemically induced convulsions. Arch Int Pharmacodyn Ther. 1964;150:118–31.

    PubMed  CAS  Google Scholar 

  • Meyer HJ, Meyer-Burg J. Inhibition of electroconvulsions by kava-pyrones dihydromethysticin and dihydrokavain. Arch Int Pharmacodyn Ther. 1964;148:97–110.

    PubMed  CAS  Google Scholar 

  • Müller B, Komorek R. Treatment with Kava-the root to combat stress. Wien Med Wochenschr. 1999;149:197–201.

    PubMed  Google Scholar 

  • Nowakowska E, Ostrowicz A, Chodera A. Kava-kava preparations-alternative anxiolytics. Pol Merkur Lekarski. 1998;4:179–80.

    PubMed  CAS  Google Scholar 

  • Pittler MH, Ernst E. Kava extract for treating anxiety. Cochrane Database Syst Rev. 2002;2:CD003383.

    Google Scholar 

  • Readon E. A drug from Polynesia with central nervous activity: Piper methysticum Forst (“kava-kava”). Gazz Med Ital. 1960;119:231–3.

    Google Scholar 

  • Riesenberg SH. Ancient kava ceremony re-enacted on Pahn Kedira, Ponape. Psychopharmacol Bull. 1967;4:5–8.

    PubMed  CAS  Google Scholar 

  • Saeed SA, Bloch RM, Antonacci DJ. Safety of kava for patients with mild anxiety disorders. Am Fam Physician. 2008;78:433–4.

    PubMed  Google Scholar 

  • Sarris J, Kavanagh DJ, Byrne G, Bone KM, Adams J, Deed G. The Kava Anxiety Depression Spectrum Study (KADSS): a randomized, placebo-controlled crossover trial using an aqueous extract of Piper methysticum. Psychopharmacology. 2009;205:399–407.

    Article  CAS  PubMed  Google Scholar 

  • Sarris J, Stough C, Bousman CA, Wahid ZT, Murray G, Teschke R, Savage KM, Dowell A, Ng C, Schweitzer I. Kava in the treatment of generalized anxiety disorder: a double-blind, randomized, placebo-controlled study. J Clin Psychopharmacol. 2013;33:643–8.

    Article  PubMed  Google Scholar 

  • Scherer J. Kava-kava extract in anxiety disorders: an outpatient observational study. Adv Ther. 1998;15:261–9.

    PubMed  CAS  Google Scholar 

  • Schliack H. Kavain in diseases of the aged. Hippokrates. 1967;38:26–30.

    PubMed  CAS  Google Scholar 

  • Schmidt N, Ferger B. Neuroprotective effects of (+/−)-kavain in the MPTP mouse model of Parkinson’s disease. Synapse. 2001;40:47–54.

    Article  CAS  PubMed  Google Scholar 

  • Shulgin AT. The narcotic pepper – the chemistry and pharmacology of Piper methysticum and related species. Bull Narc. 1973;25:59–74.

    CAS  Google Scholar 

  • Singh YN, Singh NN. Therapeutic potential of kava in the treatment of anxiety disorders. CNS Drugs. 2002;16:731–43.

    Article  PubMed  Google Scholar 

  • Smith KK, Dharmaratne HR, Feltenstein MW, Broom SL, Roach JT, Nanayakkara NP, Khan IA, Sufka KJ. Anxiolytic effects of kava extract and kavalactones in the chick social separation-stress paradigm. Psychopharmacology. 2001;155:86–90.

    Article  CAS  PubMed  Google Scholar 

  • Tawfiq RA, Nassar NH, El-Eraky WI, El-Denshary S. E. Enhanced efficacy and reduced side effects of diazepam by kava combination. J Adv Res. 2014;5:587–94.

    Article  CAS  PubMed  Google Scholar 

  • Tsutsui R, Shinomiya K, Takeda Y, Obara Y, Kitamura Y, Kamei C. Hypnotic and sleep quality-enhancing properties of kavain in sleep-disturbed rats. J Pharmacol Sci. 2009;111:293–8.

    Article  CAS  PubMed  Google Scholar 

  • Uebelhack R, Franke L, Schewe HJ. Inhibition of platelet MAO-B by kava pyrone-enriched extract from Piper methysticum Forster (kava-kava). Pharmacopsychiatry. 1998;31:187–92.

    Article  CAS  PubMed  Google Scholar 

  • Volz HP, Kieser M. Kava-kava extract WS 1490 versus placebo in anxiety disorders-a randomized placebo-controlled 25-week outpatient trial. Pharmacopsychiatry. 1997;30:1–5.

    Article  CAS  PubMed  Google Scholar 

  • Wagner WL, Herbst DR, Sohmer SH. Manual of the flowering plants of Hawai‘i. 2 vols. Honolulu: University of Hawaii Press & Bishop Museum Press; 1990.

    Google Scholar 

  • Wheatly D. Stress-induced insomnia treated with kava and valerian. Hum Psychopharmacol. 2001;16:353–6.

    Article  Google Scholar 

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Saroya, A.S., Singh, J. (2018). Piper methysticum G.Forst: A Potent Antianxiety Agent. In: Pharmacotherapeutic Potential of Natural Products in Neurological Disorders. Springer, Singapore. https://doi.org/10.1007/978-981-13-0289-3_7

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