Abstract
It is widely acknowledged that patients with functional dyspepsia have evidence of visceral hypersensitivity in the stomach. But the etiology of such hypersensitivity is relatively unstudied. It is thought that changes in the properties of visceral sensory neurons play an important role in the development of functional dyspepsia, in particular in relation to the development of gastrointestinal pain. This visceral hypersensitivity may result from dysfunction of intrinsic and extrinsic afferent neurons. The responsiveness of these nociceptive afferents is determined by the expression of specific channels sensing noxious stimuli, such as thermosensitive transient receptor potential (TRP) channel family such as TRP vanilloid 1 (TRPV1). The number of TRPV1-expressing nerve fibers and the activation of TRPV1 lead to exaggerated perception. In this review, we present an overview of the function and mediators involved in sensitization of TRPV1 channels in the pathophysiology of visceral hypersensitivity. TRPV1 has been shown to play important roles in visceral pain generation, making them potential targets in the treatment of functional dyspepsia.
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Horie, S., Matsumoto, K., Tashima, K. (2018). Visceral Hypersensitivity Through Transient Receptor Potential Vanilloid 1 Channels (TRPV1) in Functional Dyspepsia. In: Tominaga, K., Kusunoki, H. (eds) Functional Dyspepsia. Springer, Singapore. https://doi.org/10.1007/978-981-13-1074-4_10
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DOI: https://doi.org/10.1007/978-981-13-1074-4_10
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