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Overview of the Relationship Between Aluminum Exposure and Health of Human Being

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Neurotoxicity of Aluminum

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1091))

Abstract

Aluminum is a type of ubiquitously existing naturally and widely used metal in our world. It is combined with other elements and forms different compounds. In different pH and due to other conditions, it can be released into ions of different valence states. Our century is an “aluminum age”; aluminum is used in many fields of our daily life, such as vaccine adjuvant, antacids, food additives, skin care products, cosmetics, and cooking wares, and may be as elements or contaminants appeared in a lot of foods, including infant formulae, milk products, juice, wine, sea foods, and tea. It also appears in drinking water due to the water treatment process, or naturally coming from weathering rocks and soils, or released from rocks and soils caused by pollution-induced acid rain. Due to good physical and chemical property, aluminum is being tremendously utilized in many industries. In a lot of production and process procedures, aluminum particulates are seriously exposed by workers. Many factors, such as silicon, citrate, iron, calcium, fluoride, etc., can affect absorption of aluminum in human body. Human being ingests aluminum through the respiratory and digestive system and skin. Aluminum can affect our health, especially impair central nervous system. The important damage is cognitive impairment in Al-exposed peoples, Alzheimer’s disease and other neurodegenerative disorders have been related with aluminum exposure, and aluminum has been proposed as etiology.

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References

  1. Al-Ashmawy MA (2011) Prevalence and public health significance of aluminum residues in milk and some dairy products. J Food Sci 76(3):T73–T76

    Article  CAS  PubMed  Google Scholar 

  2. Amieva H, Le Goff M, Millet X, Orgogozo JM, Pérès K, Barberger-Gateau P, Jacqmin-Gadda H, Dartigues JF (2008) Prodromal Alzheimer’s disease: successive emergence of the clinical symptoms. Ann Neurol 64(5):492–498

    Article  PubMed  Google Scholar 

  3. Arnich N, Sirot V, Rivière G, Jean J, Noël L, Guérin T, Leblanc JC (2012) Dietary exposure to trace elements and health risk assessment in the 2nd French total diet study. Food Chem Toxicol 50(7):2432–2449

    Article  CAS  PubMed  Google Scholar 

  4. ATSDR (Agency for Toxic Substances and Disease Registry) (1999) A toxicological profile for aluminum. U.S. Department of Health and Human Services, Public Health Service, Atlanta

    Google Scholar 

  5. Barberger-Gateau P, Chaslerie A, Dartigues JF, Commenges D, Gagnon M, Salamon R (1992) Health measures correlates in a French elderly community population: the PAQUID study. J Gerontol 47(2):S88–S95

    Article  CAS  PubMed  Google Scholar 

  6. Barberger-Gateau P, Fabrigoule C, Helmer C, Rouch I, Dartigues JF (1999) Functional impairment in instrumental activities of daily living: an early clinical sign of dementia? J Am Geriatr Soc 47(4):456–462

    Article  CAS  PubMed  Google Scholar 

  7. Bellés M, Sánchez DJ, Gómez M, Corbella J, Domingo JL (1998) Silicon reduces aluminum accumulation in rats: relevance to the aluminum hypothesis of Alzheimer disease. Alzheimer Dis Assoc Disord 12(2):83–87

    Article  PubMed  Google Scholar 

  8. Bergomi M, Vinceti M, Nacci G, Pietrini V, Brätter P, Alber D, Ferrari A, Vescovi L, Guidetti D, Sola P, Malagu S, Aramini C, Vivoli G (2002) Environmental exposure to trace elements and risk of amyotrophic lateral sclerosis: a population-based case-control study. Environ Res 89(2):116–123

    Article  CAS  PubMed  Google Scholar 

  9. Bishop NJ, Morley R, Day JP, Lucas A (1997) Aluminum neurotoxicity in preterm infants receiving intravenous-feeding solutions. N Engl J Med 336(22):1557–1561

    Article  CAS  PubMed  Google Scholar 

  10. Braganca VL, Melnikov P, Zanoni LZ (2011) Trace elements in fruit juices. Biol Trace Elem Res 146:256–261

    Article  PubMed  CAS  Google Scholar 

  11. Brusewitz S et al (1984) USIP-84-11, Aluminium. Stockholm Univ. Inst. Theor. Phys., Stockholm, 138p

    Google Scholar 

  12. Cao H, Qiao L, Zhang H, Chen J (2010) Exposure and risk assessment for aluminium and heavy metals in Puerh tea. Sci Total Environ 408(14):2777–2784

    Article  CAS  PubMed  Google Scholar 

  13. Carney J, McAdams P, McCluskey J, Roggli VL (2016) Aluminum-induced pneumoconiosis confirmed by analytical scanning electron microscopy: a case report and review of the literature. Ultrastruct Pathol 40(3):155–158

    Article  PubMed  Google Scholar 

  14. Dabeka R, Fouquet A, Belisle S, Turcotte S (2011) Lead, cadmium and aluminum in Canadian infant formulae, oral electrolytes and glucose solutions. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 28(6):744–753

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Dartigues JF, Gagnon M, Letenneur L, Barberger-Gateau P, Commenges D, Evaldre M, Salamon R (1992) Principal lifetime occupation and cognitive impairment in a French elderly cohort (Paquid). Am J Epidemiol 135(9):981–988

    Article  CAS  PubMed  Google Scholar 

  16. Divine KK, Lewis JL, Grant PG, Bench G (1999) Quantitative particle-induced X-ray emission imaging of rat olfactory epithelium applied to the permeability of rat epithelium to inhaled aluminum. Chem Res Toxicol 12(7):575–581

    Article  CAS  PubMed  Google Scholar 

  17. Dockery DW, Pope CA 3rd, Xu X, Spengler JD, Ware JH, Fay ME, Ferris BG Jr, Speizer FE (1993) An association between air pollution and mortality in six US cities. N Engl J Med 329(24):1753–1759

    Article  CAS  PubMed  Google Scholar 

  18. Englert N (2004) Fine particles and human health – a review of epidemiological studies. Toxicol Lett 149(1–3):235–242. Review

    Article  CAS  PubMed  Google Scholar 

  19. Eng PJ, Trainor TP, Brown GE Jr, Waychunas GA, Newville M, Sutton SR, Rivers ML (2000) Structure of the hydrated alpha-Al(2)O(3) (0001) surface. Science 288(5468):1029–1033

    Article  CAS  PubMed  Google Scholar 

  20. Ferreira PC, Piai Kde A, Takayanagui AM, Segura-Muñoz SI (2008) Aluminum as a risk factor for Alzheimer’s disease. Rev Lat Am Enfermagem 16(1):151–157

    Article  PubMed  Google Scholar 

  21. Flaten TP (2001) Aluminium as a risk factor in Alzheimer's disease, with emphasis on drinking water. Brain Res Bull 55(2):187–196. Review

    Article  CAS  PubMed  Google Scholar 

  22. Flaten TP (1990) Geographical associations between aluminium in drinking water and death rates with dementia (including Alzheimer’s disease), Parkinson’s disease and amyotrophic lateral sclerosis in Norway. Environ Geochem Health 12:152–167

    Article  CAS  PubMed  Google Scholar 

  23. Forbes WF, Agwani N (1994) A suggested mechanism for aluminum biotoxicity. J Theor Biol 171(2):207–214

    Article  CAS  PubMed  Google Scholar 

  24. Forbes WF, Gentleman JF, Maxwell CJ (1995) Concerning the role of aluminum in causing dementia. Exp Gerontol 30(1):23–32

    Article  CAS  PubMed  Google Scholar 

  25. Forbes WF, Hayward LM, Agwani N (1992) Aluminum and Alzheimer’s disease. CMAJ 146(9):1534

    CAS  PubMed  PubMed Central  Google Scholar 

  26. Forbes WF, Hayward LM, Agwani N (1991) Dementia, aluminium, and fluoride. Lancet 338(8782–8783):1592–1593

    Article  CAS  PubMed  Google Scholar 

  27. Forbes WF, Hill GB (1998) Is exposure to aluminum a risk factor for the development of Alzheimer disease? Yes. Arch Neurol 55(5):740–741

    Article  CAS  PubMed  Google Scholar 

  28. Forbes WF, McLachlan DR (1996) Further thoughts on the aluminum-Alzheimer’s disease link. J Epidemiol Community Health 50(4):401–403

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Forster DP, Newens AJ, Kay DW, Edwardson JA (1995) Risk factors in clinically diagnosed presenile dementia of the Alzheimer type: a case-control study in northern England. J Epidemiol Community Health 49(3):253–258

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Frankowski M, Zioła-Frankowska A, Kurzyca I, Novotný K, Vaculovič T, Kanický V, Siepak M, Siepak J (2011) Determination of aluminium in groundwater samples by GF-AAS, ICP-AES, ICP-MS and modelling of inorganic aluminium complexes. Environ Monit Assess 182(1–4):71–84

    Article  CAS  PubMed  Google Scholar 

  31. Frecker MF (1991) Dementia in Newfoundland: identification of a geographical isolate? J Epidemiol Community Health 45(4):307–311

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. French P, Gardner MJ, Gunn AM (1989) Dietary aluminium and Alzheimer’s disease. Food Chem Toxicol 27(7):495–498

    Article  CAS  PubMed  Google Scholar 

  33. Fulton B, Jaw S, Jeffery EH (1989) Bioavailability of aluminum from drinking water. Fundam Appl Toxicol 12(1):144–150

    Article  CAS  PubMed  Google Scholar 

  34. Garruto RM, Fukatsu R, Yanagihara R, Gajdusek DC, Hook G, Fiori CE (1984) Imaging of calcium and aluminum in neurofibrillary tangle-bearing neurons in parkinsonism-dementia of Guam. Proc Natl Acad Sci U S A 81(6):1875–1879

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Gauthier E, Fortier I, Courchesne F, Pepin P, Mortimer J, Gauvreau D (2000) Aluminum forms in drinking water and risk of Alzheimer’s disease. Environ Res 84(3):234–246

    Article  CAS  PubMed  Google Scholar 

  36. Glynn AW, Sparén A, Danielsson LG, Sundström B, Jorhem L (2001) The influence of complexing agents on the solubility and absorption of aluminium in rats exposed to aluminium in water. Food Addit Contam 18(6):515–523

    Article  CAS  PubMed  Google Scholar 

  37. Graves AB, White E, Koepsell TD, Reifler BV, van Belle G, Larson EB (1990) The association between aluminum-containing products and Alzheimer’s disease. J Clin Epidemiol 43(1):35–44

    Article  CAS  PubMed  Google Scholar 

  38. Guerin T, Chekri R, Vastel C, Sirot V, Volatier J-L, Leblanc J-C, Noel L (2011) Determination of 20 trace elements in fish and other seafood from the French market. Food Chem 127:934–942

    Article  CAS  PubMed  Google Scholar 

  39. Harris WR (1992) Equilibrium model for speciation of aluminum in serum. Clin Chem 38:1809–1818

    CAS  PubMed  Google Scholar 

  40. He SC, Qiao N, Sheng W (2003) Neurobehavioral, autonomic nervous function and lymphocyte subsets among aluminum electrolytic workers. Int J Immunopathol Pharmacol 16(2):139–144

    Article  CAS  PubMed  Google Scholar 

  41. Health Canada (2010) Aluminum chloride, aluminum nitrate, aluminum sulfate. Priority Substances List Assessment Report. Follow-up to the State of Science Report 2000. Environment Canada, Ottawa. Available at: http://www.ec.gc.ca/CEPARegistry/documents/subs_list/Aluminium_Salts/final/Al_salts__toc.cfm

  42. Hoflich BL, Weinbruch S, Theissmann R, Gorzawski H, Ebert M, Ortner HM, Skogstad A, Ellingsen DG, Drablos PA, Thomassen Y (2005) Characterization of individual aerosol particles in workroom air of aluminium smelter potrooms. J Environ Monit 7(5):419–424

    Article  PubMed  CAS  Google Scholar 

  43. Ilyin A, Gromov A, An F, Faubert V, de Izarra C, Espagnscq A, Brunet L (2002) Characterization of aluminum powders I. Influence of renal impairment, chemical form, and serum protein binding on intravenous and oral aluminum kinetics in the rabbit. Toxicol Appl Pharmacol 1988 95(1):32–43

    Google Scholar 

  44. IPCS (International Programme on Chemical Safety) (1997) Aluminum. Environmental health criteria 194. World Health Organization, Geneva

    Google Scholar 

  45. Jinzhu Y, Qinli Z, Jin Y, Pan K, Jianjun H, Qiao N (2015) Aluminum and benzo[a]pyrene co-operate to induce neuronal apoptosis in vitro. J Toxicol Sci 40(3):365–373

    Article  PubMed  Google Scholar 

  46. Kihira T, Yoshida S, Mitani K, Yasui M, Yase Y (1993) ALS in the Kii peninsula of Japan, with special reference to neurofibrillary tangles and aluminum. Neuropathology 13(2):125–136

    Article  Google Scholar 

  47. Kihira T, Kanno S, Miwa H, Okamoto K, Kondo T (2007) The role of exogenous risk factors in amyotrophic lateral sclerosis in Wakayama. Jpn Amyotroph Lateral Scler 8(3):150–156

    Article  Google Scholar 

  48. Kongerud J, Søyseth V (2014) Respiratory disorders in aluminum smelter workers. J Occup Environ Med 56(5 Suppl):S60–S70

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Krewski D, Yokel RA, Nieboer E, Borchelt D, Cohen J, Harry J, Kacew S, Lindsay J, Mahfouz AM, Rondeau V (2007) Human health risk assessment for aluminium, aluminium oxide, and aluminium hydroxide. J Toxicol Environ Health B Crit Rev 10(Suppl 1):1–269

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  50. Li G, Zhao X, Wu S, Hua H, Wang Q, Zhang Z (2017) Dietary exposure to aluminium in the popular Chinese fried bread youtiao. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 11:1–8

    Article  CAS  Google Scholar 

  51. Liya Ge, Jianghong Jiang, Xiaoyan Wu (2009) Investigation on aluminum content in Youtiao in Wuhan. Spectr Instrum Anal Z1:61–64

    Google Scholar 

  52. L’vov BV, Polzik LK, Weinbruch S, Ellingsen DG, Thomassen Y (2005) Theoretical aspects of fluoride air contaminant formation in aluminium smelter potrooms. J Environ Monit 7(5):425–430

    Article  PubMed  CAS  Google Scholar 

  53. Lu X, Liang R, Jia Z, Wang H, Pan B, Zhang Q, Niu Q (2014) Cognitive disorders and tau-protein expression among retired aluminum smelting workers. J Occup Environ Med 56(2):155–160

    Article  CAS  PubMed  Google Scholar 

  54. Maitani T, Kubota H, Hori N, Yoshihira K, Takeda M (1994) Distribution and urinary excretion of aluminium injected with several organic acids into mice: relationship with chemical state in serum studied by the HPLC-ICP method. J Appl Toxicol 14(4):257–261

    Article  CAS  PubMed  Google Scholar 

  55. Maltseva A, Serra C, Kogevinas M (2016) Cancer risk among workers of a secondary aluminium smelter. Occup Med (Lond) 66(5):412–414

    Article  CAS  Google Scholar 

  56. Markesbery WR, Ehmann WD, Alauddin M, Hossain TI (1984) Brain trace element concentrations in aging. Neurobiol Aging 5(1):19–28

    Article  CAS  PubMed  Google Scholar 

  57. Martyn CN, Coggon DN, Inskip H, Lacey RF, Young WF (1997) Aluminum concentrations in drinking water and risk of Alzheimer’s disease. Epidemiology 8(3):281–286

    Article  CAS  PubMed  Google Scholar 

  58. Martyn CN, Barker DJ, Osmond C, Harris EC, Edwardson JA, Lacey RF (1989) Geographical relation between Alzheimer’s disease and aluminum in drinking water. Lancet 1(8629):59–62

    Article  CAS  PubMed  Google Scholar 

  59. McLachlan DR, Bergeron C, Smith JE, Boomer D, Rifat SL (1996) Risk for neuropathologically confirmed Alzheimer’s disease and residual aluminum in municipal drinking water employing weighted residential histories. Neurology 46(2):401–405

    Article  CAS  PubMed  Google Scholar 

  60. Millour S, Noel L, Kadar A, Chekri R, Vastel CH, Sirot V et al (2011) Pb, Hg, Cd, As, Sb and Al levels in foodstuffs from the 2nd French total diet study. Food Chem 126:1787–1799

    Article  CAS  PubMed  Google Scholar 

  61. Mizumoto Y, Iwata S, Sasajima K, Yoshida S, Yoshimasu F, Yase Y (1983) Determination of the Ca/P atomic ratio in the spinal cord of patients with amyotrophic lateral sclerosis by neutron activation and X-ray fluorescence analysis. Radioisotopes 32(11):551–554. Japanese

    Article  CAS  PubMed  Google Scholar 

  62. Mussi I, Calzaferri G, Buratti M, Alessio L (1984) Behaviour of plasma and urinary aluminium levels in occupationally exposed subjects. Int Arch Occup Environ Health 54:155–161

    Article  CAS  PubMed  Google Scholar 

  63. Nancy Chuchu, Bhavini Patel, Blaise Sebastian, Christopher Exley (2013) The aluminium content of infant formulas remains too high. BMC Pediatr 13:162–166

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  64. Neri LC, Hewitt D (1991) Aluminium, Alzheimer’s disease, and drinking water. Lancet 338(8763):390

    Article  CAS  PubMed  Google Scholar 

  65. Nieboer E, Thomassen Y, Chashchin V, Odland JØ (2005) Occupational exposure assessment of metals. J Environ Monit 7(5):412–415. Review

    PubMed  Google Scholar 

  66. Nolte E, Beck E, Winklhofer C, Steinhausen C (2001) Compartmental model for aluminium biokinetics. Hum Exp Toxicol 20(2):111–117

    Article  CAS  PubMed  Google Scholar 

  67. Polizzi S, Pira E, Ferrara M, Bugiani M, Papaleo A, Albera R, Palmi S (2002) Neurotoxic effects of aluminium among foundry workers and Alzheimer’s disease. Neurotoxicology 23(6):761–774

    Article  CAS  PubMed  Google Scholar 

  68. Ohno K, Ishikawa K, Kurosawa Y, Matsui Y, Matsushita T, Magara Y (2010) Exposure assessment of metal intakes from drinking water relative to those from total diet in Japan. Water Sci Technol 62:2694–2701

    Article  PubMed  CAS  Google Scholar 

  69. Ondreicka R, Ginter E, Kortus J (1967) Effect of increased doses of aluminum salts on the metabolism of experimental animals. Cesk Gastroenterol Vyz 21(1):40–51

    CAS  PubMed  Google Scholar 

  70. Perl DP, Gajdusek DC, Garruto RM, Yanagihara RT, Gibbs CJ (1982) Intraneuronal aluminum accumulation in amyotrophic lateral sclerosis and Parkinsonism-dementia of Guam. Science 217(4564):1053–1055

    Article  CAS  PubMed  Google Scholar 

  71. Perl DP, Pendlebury WW (1986) Aluminum neurotoxicity – potential role in the pathogenesis of neurofibrillary tangle formation. Can J Neurol Sci 13(4 Suppl):441–445

    Article  CAS  PubMed  Google Scholar 

  72. Piccardo P, Yanagihara R, Garruto RM, Gibbs CJ Jr, Gajdusek DC (1988) Histochemical and X-ray microanalytical localization of aluminum in amyotrophic lateral sclerosis and parkinsonism-dementia of Guam. Acta Neuropathol 77(1):1–4

    Article  CAS  PubMed  Google Scholar 

  73. Powell JJ, Greenfield SM, Parkes HG, Nicholson JK, Thompson RP (1993) Gastro-intestinal availability of aluminium from tea. Food Chem Toxicol 31(6):449–454

    Article  CAS  PubMed  Google Scholar 

  74. Powell JJ, Thompson RP (1993) The chemistry of aluminium in the gastrointestinal lumen and its uptake and absorption. Proc Nutr Soc 52(1):241–253

    Article  CAS  PubMed  Google Scholar 

  75. Zhang QL, Li MQ, Ji JW, Gao FP, Bai R, Chen CY, Wang ZW, Zhang C, Niu Q (2011) In vivo toxicity of nano-alumina on mice neurobehavioral profiles and the potential mechanisms. Int J Immunopathol Pharmacol 24(1S):23–29

    Google Scholar 

  76. Ramírez-Altamirano Mde J, Fenton-Navarro P, Sivet-Chiñas E, Harp-Iturribarria Fde M, Martínez-Cruz R, Cruz PH, Cruz MM, Pérez-Campos E (2012) The relationship of aluminium and silver to neural tube defects; a case control. Iran J Pediatr 22(3):369–374

    PubMed  Google Scholar 

  77. Rajasekaran K (2000) Effects of combined exposure to aluminium, ethanol on food intake, motor behaviour, a few biochemical parameters in pubertal rats. Environ Toxicol Pharmacol 9:25–30

    Google Scholar 

  78. Rossbach B, Buchta M, Csanády GA, Filser JG, Hilla W, Windorfer K, Stork J, Zschiesche W, Gefeller O, Pfahlberg A, Schaller KH, Egerer E, Escobar Pinzón LC, Letzel S (2006) Biological monitoring of welders exposed to aluminium. Toxicol Lett 162(2–3):239–245

    Article  CAS  PubMed  Google Scholar 

  79. Santibáñez M, Bolumar F, García AM (2007) Occupational risk factors in Alzheimer’s disease: a review assessing the quality of published epidemiological studies. Occup Environ Med 64(11):723–732

    Article  PubMed  PubMed Central  Google Scholar 

  80. Sauvel C, Barberger-Gateau P, Dequae L, Letenneur L, Dartigues JF (1994) Factors associated with a 1-year development in the functional autonomy of elderly persons living at home. Rev Epidemiol Sante Publique 42(1):13–23. French

    CAS  PubMed  Google Scholar 

  81. Shimizu H, Mori T, Koyama M, Sekiya M, Ooami H (1994) A correlative study of the aluminum content and aging changes of the brain in non-demented elderly subjects. Nihon Ronen Igakkai Zasshi 31(12):950–960. Japanese

    Article  CAS  PubMed  Google Scholar 

  82. Sjögren B, Lundberg I, Lidums V (1983) Aluminium in the blood and urine of industrially exposed workers. Br J Ind Med 40:301–304

    Article  CAS  Google Scholar 

  83. Stahl T, Taschan H, Brunn H (2011) Aluminium content of selected foods and food products. Environ Sci Eur 23:37–48

    Article  Google Scholar 

  84. Stitch SR (1957) Trace elements in human tissue. 1. A semi-quantitative spectrographic survey. Biochem J 67(1):97–103

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  85. Tariba B (2011) Metals in wine-impact on wine quality and health outcomes. Biol Trace Elem Res 144:143–156

    Article  CAS  PubMed  Google Scholar 

  86. Taneda M (1984) Effect of aluminum on rat brain. Enhancement by calcium deficiency. Hokkaido Igaky Zasshi 59(3):312–337

    CAS  Google Scholar 

  87. The Health and Population Planing Commission of China (2014, December 24) National Standard for Food Safety-food additives utilization standard

    Google Scholar 

  88. Thomassen Y, Koch W, Dunkhorst W, Ellingsen DG, Skaugset NP, Jordbekken L, Arne Drabløs P, Weinbruch S (2006) Ultrafine particles at workplaces of a primary aluminium smelter. J Environ Monit 8(1):127–133

    Article  CAS  PubMed  Google Scholar 

  89. Traub RD, Rains TC, Garruto RM, Gajdusek DC, Gibbs CJ Jr (1981) Brain destruction alone does not elevate brain aluminum. Neurology 31(8):986–990

    Article  CAS  PubMed  Google Scholar 

  90. Van der Voet GB, de Wolff FA (1987a) Intestinal absorption of aluminium in rats: effect of sodium. Arch Toxicol Suppl 11:231–235

    PubMed  Google Scholar 

  91. Van der Voet GB, De Wolff FA (1987b) The effect of di- and trivalent iron on the intestinal absorption of aluminum in rats. Toxicol Appl Pharmacol 90(2):190–197

    Article  PubMed  Google Scholar 

  92. Virk SA, Eslick GD (2015) Occupational exposure to aluminum and Alzheimer disease: a meta-analysis. J Occup Environ Med 57(8):893–896

    Article  CAS  PubMed  Google Scholar 

  93. Wagner W (1999) Canadian minerals yearbook. Natural Resources Canada, Ottawa

    Google Scholar 

  94. Walton J, Hams G, Wilcox D (1994) Bioavailability of Aluminium from drinking water: co-exposure with foods and beverages, Research Report No. 83. Urban Water Research Association of Australia, Melbourne Water Corporation, Melbourne

    Google Scholar 

  95. Wang W, Yang H, Wang X, Jiang J, Zhu W (2010) Effects of fulvic acid and humic acid on aluminum speciation in drinking water. J Environ Sci (China) 22(2):211–217

    Article  CAS  Google Scholar 

  96. Weidenhamer JD, Fitzpatrick MP, Biro AM, Kobunski PA, Hudson MR, Corbin RW, Gottesfeld P (2017) Metal exposures from aluminum cookware: an unrecognized public health risk in developing countries. Sci Total Environ 579:805–813

    Article  CAS  PubMed  Google Scholar 

  97. Weinbruch S, Benker N, Koch W, Ebert M, Drablos PA, Skaugset NP et al (2010) Hygroscopic properties of the workroom aerosol in aluminium smelter potrooms: a case for transport of HF and SO2 into the lower airways. J Environ Monit 12:448–454

    Article  CAS  PubMed  Google Scholar 

  98. Westberg HB, Seldén AI, Bellander T (2001) Exposure to chemical agents in Swedish aluminum foundries and aluminum remelting plants – a comprehensive survey. Appl Occup Environ Hyg 16(1):66–77

    Article  CAS  PubMed  Google Scholar 

  99. Wettstein A, Aeppli J, Gautschi K, Peters M (1991) Failure to find a relationship between mnestic skills of octogenarians and aluminum in drinking water. Int Arch Occup Environ Health 63(2):97–103

    Article  CAS  PubMed  Google Scholar 

  100. Wood DJ, Cooper C, Stevens J, Edwardson J (1988) Bone mass and dementia in hip fracture patients from areas with different aluminium concentrations in water supplies. Age Ageing 17(6):415–419

    Article  CAS  PubMed  Google Scholar 

  101. Yase Y, Matsumoto N, Azuma K, Nakai Y, Shiraki H (1972) Amyotrophic lateral sclerosis. Association with schizophrenic symptoms and showing Alzheimer’s tangles. Arch Neurol 27(2):118–128

    Article  CAS  PubMed  Google Scholar 

  102. Yasui M, Ota K (1992) Experimental and clinical studies on dysregulation of magnesium metabolism and the aetiopathogenesis of multiple sclerosis. Magnes Res 5(4):295–302

    CAS  PubMed  Google Scholar 

  103. Yasui M, Yase Y, Ota K, Garruto RM (1991a) Aluminum deposition in the central nervous system of patients with amyotrophic lateral sclerosis from the Kii Peninsula of Japan. Neurotoxicology 12(3):615–620

    CAS  PubMed  Google Scholar 

  104. Yasui M, Yase Y, Ota K, Mukoyama M, Adachi K (1991b) High aluminum deposition in the central nervous system of patients with amyotrophic lateral sclerosis from the Kii Peninsula, Japan: two case reports. Neurotoxicology 12(2):277–283

    CAS  PubMed  Google Scholar 

  105. Yasui M, Ota K, Yoshida M (1997) Effects of low calcium and magnesium dietary intake on the central nervous system tissues of rats and calcium-magnesium related disorders in the amyotrophic lateral sclerosis focus in the Kii Peninsula of Japan. Magnes Res 10(1):39–50

    Google Scholar 

  106. Yokel RA (2013) Aluminum. In: Cabello A (ed) Encyclopedia of human nutrition, vol 1, 3rd edn. Academic, Waltham, pp 57–56

    Chapter  Google Scholar 

  107. Yokel RA, McNamara PJ (1985) Aluminum bioavailability and disposition in adult and immature rabbits. Toxicol Appl Pharmacol 77(2):344–352

    Article  CAS  PubMed  Google Scholar 

  108. Yokel RA, McNamara PJ (1988) Influence of renal impairment, chemical form, and serum protein binding on intravenous and oral aluminum kinetics in the rabbit. Toxicol Appl Pharmacol 98(1):32–43

    Article  CAS  PubMed  Google Scholar 

  109. Yokel RA Ei-Samragy Y (2012) Aluminum in food-the nature and contribution of food additives. In Tech:203–228. Available at http://www.intechopen.com/articles/show/title/aluminum-in-food-the-nature-and-contributionof-food-additives

    Google Scholar 

  110. Yoshida S, Yoshimasu F, Yase Y, Kawai K, Iwata S (1980) Metal analysis in CNS tissue of ALS case – related to the high content of heavy metals in his drinking water (author’s transl). Rinsho Shinkeigaku 20(1):16–24

    CAS  PubMed  Google Scholar 

  111. Yoshimasu F, Uebayashi Y, Yase Y, Iwata S, Sasajima K (1976) Studies on amyotrophic lateral sclerosis by neutron activation analysis. Folia Psychiatr Neurol Jpn 30(1):49–55

    CAS  PubMed  Google Scholar 

  112. Yoshimasu F, Yasui M, Yase Y, Iwata S, Gajdusek DC, Gibbs CJ Jr, Chen KM (1980) Studies on amyotrophic lateral sclerosis by neutron activation analysis – 2. Comparative study of analytical results on Guam PD, Japanese ALS and Alzheimer disease cases. Folia Psychiatr Neurol Jpn 34(1):75–82

    CAS  PubMed  Google Scholar 

  113. Yoshimasu F, Yasui M, Yoshida H, Yoshida S, Yase Y (1985) Metal studies on Alzheimer disease by neutron activation analysis. Rinsho Shinkeigaku 25(6):738–743. [Article in Japanese]

    CAS  PubMed  Google Scholar 

  114. Zapatero MD, Garcia de Jalon A, Pascual F, Calvo ML, Escanero J, Marro A (1995) Serum aluminum levels in Alzheimer’s disease and other senile dementias. Biol Trace Elem Res 47(1–3):235–240

    Article  CAS  PubMed  Google Scholar 

  115. Zhang JL, Liu GY (2007) Main resources of aluminum ingested by human body. Chin J Health Lab Technol 17(11):1934–1936

    Google Scholar 

  116. Zhang Q, Wang H, Ge C, Duncan J, He K, Adeosun SO, Xi H, Peng H, Niu Q (2017) Alumina at 50 and 13 nm nanoparticle sizes have potential genotoxicity. J Appl Toxicol 37(9):1053–1064

    Article  CAS  PubMed  Google Scholar 

  117. Zhang Q, Xu L, Wang J, Sabbioni E, Piao L, Di Gioacchino M, Niu Q (2013) Lysosomes involved in the cellular toxicity of nano-alumina: combined effects of particle size and chemical composition. J Biol Regul Homeost Agents 27(2):365–375

    PubMed  Google Scholar 

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  1. Department of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan, Shanxi, China

    Qiao Niu

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    Qiao Niu

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Niu, Q. (2018). Overview of the Relationship Between Aluminum Exposure and Health of Human Being. In: Niu, Q. (eds) Neurotoxicity of Aluminum. Advances in Experimental Medicine and Biology, vol 1091. Springer, Singapore. https://doi.org/10.1007/978-981-13-1370-7_1

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