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Recent Development of Chemical Synthesis of RNA

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Synthesis of Therapeutic Oligonucleotides

Abstract

Recent studies on the chemical synthesis of RNA and related derivatives are reviewed. In particular, a variety of new 2′-hydroxyl protecting groups that are developed during the past decade are described and compared with the conventional ones from the organochemical point of view. Great improvements in the coupling efficiency and suppression of side reactions during RNA synthesis cycles are described in great detail. The methods and associated problems for constructing the key synthetic intermediates, i.e., 2′-O-protected ribonucleoside 3′-phosphoramidite building blocks, are also discussed.

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  1. Tokyo Institute of Technology, Yokohama, Kanagawa, Japan

    Mitsuo Sekine

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  1. Mitsuo Sekine
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Editors and Affiliations

  1. Osaka University, Suita, Osaka, Japan

    Satoshi Obika

  2. Tokyo Institute of Technology, Yokohama, Kanagawa, Japan

    Mitsuo Sekine

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Sekine, M. (2018). Recent Development of Chemical Synthesis of RNA. In: Obika, S., Sekine, M. (eds) Synthesis of Therapeutic Oligonucleotides. Springer, Singapore. https://doi.org/10.1007/978-981-13-1912-9_3

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