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Biomarkers in Pediatric Acute Kidney Injury

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Critical Care Pediatric Nephrology and Dialysis: A Practical Handbook

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Abstract

Serum creatinine and urine output are imprecise and unreliable measures of structural acute kidney injury (AKI). Novel non-invasive structural AKI biomarkers improve diagnostic and therapeutic patient care by allowing earlier detection of tissue injury at a time when inciting factors can still be modified and response to interventions trended in real-time. Neutrophil gelatinase-associated lipocalin (NGAL) is the most well-established AKI biomarker, validated in pediatric populations, and is already being employed effectively in the clinical setting using widely available standardized clinical platforms. AKI risk, severity stratification, and prognosis are dose-dependent and can be trended in real-time using categories based on urine or plasma NGAL levels: low risk <50 ng/mL, equivocal 50–150 ng/mL, moderate risk 150–300 ng/mL, and high risk >300 ng/mL.

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Authors and Affiliations

  1. Nephrology and Hypertension, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA

    Eileen Ciccia & Prasad Devarajan

Authors
  1. Eileen Ciccia
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  2. Prasad Devarajan
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Corresponding author

Correspondence to Prasad Devarajan .

Editor information

Editors and Affiliations

  1. Kidney & Urology Institute, Medanta, The Medicity Kidney & Urology Institute, Gurugram, Haryana, India

    Sidharth Kumar Sethi

  2. Department of Nephrology, Cleveland Clinic Akron General Medical center and Akron Children’s Hospital, Akron, OH, USA

    Rupesh Raina

  3. Red Cross War Memorial Children’s Hospital, University of Cape Town, Cape Town, South Africa

    Mignon McCulloch

  4. Pediatric Nephrology, Children’s Hospital of Richmond at the Virginia Commonwealth University, Richmond, VA, USA

    Timothy E. Bunchman

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© 2019 Springer Nature Singapore Pte Ltd.

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Ciccia, E., Devarajan, P. (2019). Biomarkers in Pediatric Acute Kidney Injury. In: Sethi, S., Raina, R., McCulloch, M., Bunchman, T. (eds) Critical Care Pediatric Nephrology and Dialysis: A Practical Handbook. Springer, Singapore. https://doi.org/10.1007/978-981-13-2276-1_2

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  • DOI: https://doi.org/10.1007/978-981-13-2276-1_2

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-13-2275-4

  • Online ISBN: 978-981-13-2276-1

  • eBook Packages: MedicineMedicine (R0)

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