Abstract
Aldehyde dehydrogenase 2 (ALDH2) is a member of ALDH family. ALDH1 has been widely recognized for its roles in carcinogenesis and cancer therapy; however, investigation for ALDH2 in cancer is seldom mentioned. The ALDH2 point mutation ALDH2*2 is the most frequent human gene variant, and it is present in approximately 560 million East Asians. ALDH2*2 demonstrates its effect on alcohol consumption limiting and alcoholism developing protection, and this variant is recently found to have an important impact on human health. This chapter focuses on its potential effect on cancer therapy, especially for chemotherapeutics with anthracyclines.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
(a) Shao C, Sullivan JP, Girard L, Augustyn A, Yenerall P, Rodriguez-Canales J, Liu H, Behrens C, Shay JW, Wistuba II, Minna JD (2014) Clin Cancer Res 20:4154–4166; (b) Liu X, Wang L, Cui W, Yuan X, Lin L, Cao Q, Wang N, Li Y, Guo W, Zhang X, Wu C, Yang J (2016) Oncotarget 7:58516–58530
Gross ER, Zambelli VO, Small BA, Ferreira JC, Chen CH, Mochly-Rosen D (2015) Annu Rev Pharmacol Toxicol 55:107–127
Li H, Borinskaya S, Yoshimura K, Kal’ina N, Marusin A, Stepanov VA, Qin Z, Khaliq S, Lee MY, Yang Y, Mohyuddin A, Gurwitz D, Mehdi SQ, Rogaev E, Jin L, Yankovsky NK, Kidd JR, Kidd KK (2009) Ann Hum Genet 73:335–345
Chen CH, Ferreira JC, Gross ER, Mochly-Rosen D (2014) Physiol Rev 94:1–34
Chen CH, Budas GR, Churchill EN, Disatnik MH, Hurley TD, Mochly-Rosen D (2008) Science 321:1493–1495
(a) Burke WJ, Li SW, Williams EA, Nonneman R, Zahm DS (2003) Brain Res 989:205–213; (b) Chan JC, Malik V, Jia W, Kadowaki T, Yajnik CS, Yoon KH, Hu FB (2009) JAMA 301:2129–2140; (c) Wenzel P, Muller J, Zurmeyer S, Schuhmacher S, Schulz E, Oelze M, Pautz A, Kawamoto T, Wojnowski L, Kleinert H, Munzel T, Daiber A (2008) Biochem Biophys Res Commun 367:137–143; (d) Sun A, Cheng Y, Zhang Y, Zhang Q, Wang S, Tian S, Zou Y, Hu K, Ren J, Ge J (2014) J Mol Cell Cardiol 71:92–104
Li R, Zhao Z, Sun M, Luo J, Xiao Y (2016) Life Sci 147:59–66
Andrew AS, Gui J, Hu T, Wyszynski A, Marsit CJ, Kelsey KT, Schned AR, Tanyos SA, Pendleton EM, Ekstrom RM, Li Z, Zens MS, Borsuk M, Moore JH, Karagas MR (2015) BJU Int 115:238–247
Dumontet C, Landi S, Reiman T, Perry T, Plesa A, Bellini I, Barale R, Pilarski LM, Troncy J, Tavtigian S, Gemignani F (2010) Bone Marrow Transplant 45:1316–1324
Bar-Ad V, Palmer J, Yang H, Cognetti D, Curry J, Luginbuhl A, Tuluc M, Campling B, Axelrod R (2014) Semin Oncol 41:798–806
Kim J, Chen CH, Yang J, Mochly-Rosen D (2017) J Biomed Sci 24:33
(a) Yabuki N, Sakata K, Yamasaki T, Terashima H, Mio T, Miyazaki Y, Fujii T, Kitada K (2007) Cancer Genet Cytogenet 173:1–9; (b) Sato H, Fukumoto K, Hada S, Hagiwara H, Fujimoto E, Negishi E, Ueno K, Yano T (2007) Cancer Chemother Pharmacol 60:449–457
(a) Kavallaris M, Burkhart CA, Horwitz SB (1999) Br J Cancer 80:1020–1025; (b) Seve P, Isaac S, Tredan O, Souquet PJ, Pacheco Y, Perol M, Lafanechere L, Penet A, Peiller EL, Dumontet C (2005) Clin Cancer Res 11:5481–5486
Dean M, Fojo T, Bates S (2005) Nat Rev Cancer 5:275–284
Wang NN, Wang LH, Li Y, Fu SY, Xue X, Jia LN, Yuan XZ, Wang YT, Tang X, Yang JY, Wu CF (2018) Exp Cell Res 362:72–82
(a) Minotti G, Menna P, Salvatorelli E, Cairo G, Gianni L (2004) Pharmacol Rev 56:185–229; (b) Ewer MS, Ewer SM (2010) Nat Rev Cardiol 7:564–575
(a) Gianni L, Herman EH, Lipshultz SE, Minotti G, Sarvazyan N, Sawyer DB (2008) J Clin Oncol 26:3777–3784; (b) Sawyer DB (2013) N Engl J Med 368:1154–1156
(a) Mordente A, Meucci E, Silvestrini A, Martorana GE, Giardina B (2009) Curr Med Chem 16:1656–1672; (b) Ichikawa Y, Ghanefar M, Bayeva M, Wu R, Khechaduri A, Naga Prasad SV, Mutharasan RK, Naik TJ, Ardehali H (2014) J Clin Invest 124:617–630
Moreb JS, Ucar D, Han S, Amory JK, Goldstein AS, Ostmark B, Chang LJ (2012) Chem Biol Interact 195:52–60
Gao YH, Wu ZX, Xie LQ, Li CX, Mao YQ, Duan YT, Han B, Han SF, Yu Y, Lu HJ, Yang PY, Xu TR, Xia JL, Chen GQ, Wang LS (2017) Nat Commun 8:15337
(a) Stewart MJ, Dipple KM, Estonius M, Nakshatri H, Everett LM, Crabb DW (1998) Biochim Biophys Acta 1399:81–186; (b) You M, Fischer M, Cho WK, Crabb D (2002) Arch Biochem Biophys 398:79–86
Gao Y, Xu Y, Hua S, Zhou S, Wang K (2015) Int J Clin Exp Med 8:6794–6803
Ge W, Yuan M, Ceylan AF, Wang X, Ren J (2016) Biochim Biophys Acta 1862:622–634
Ning S, Budas GR, Churchill EN, Chen CH, Knox SJ, Mochly-Rosen D (2012) Radiat Res 178:69–74
Uomori T, Horimoto Y, Mogushi K, Matsuoka J, Saito M (2017) Breast Cancer 24:702–707
Yokoyama A, Brooks PJ, Yokoyama T, Mizukami T, Shiba S, Nakamoto N, Maruyama K (2017) Jpn J Clin Oncol 47:306–312
Langevin F, Crossan GP, Rosado IV, Arends MJ, Patel KJ (2011) Nature 475:53–58
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Wang, LS., Wu, ZX. (2019). ALDH2 and Cancer Therapy. In: Ren, J., Zhang, Y., Ge, J. (eds) Aldehyde Dehydrogenases. Advances in Experimental Medicine and Biology, vol 1193. Springer, Singapore. https://doi.org/10.1007/978-981-13-6260-6_13
Download citation
DOI: https://doi.org/10.1007/978-981-13-6260-6_13
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-13-6259-0
Online ISBN: 978-981-13-6260-6
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)