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Pharmacology of Red Sanders

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Red Sanders: Silviculture and Conservation

Abstract

A wide array of biological activities and potential health benefits of P. santalinus have been reported including antioxidative, antidiabetic, antimicrobial, anticancer, anti-inflammatory properties as well as protective effects on the liver, gastric mucosa and nervous systems. All these protective effects were attributed to bioactive compounds present in P. santalinus. The present chapter describes the pharmacological effects of P. santalinus in health and disease with an update.

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References

  • Achary JD, Ghaskadbi SS (2013) Protective effect of pterostilbene against free radical mediated oxidative damage. BMC Complement Altern Med 13:238

    Article  Google Scholar 

  • Arokiyaraj A, Perinbam K (2010) Antifungal activity of Pterocarpus santalinus an in vitro study. Biomed Pharmacol J 3(1):263–265

    CAS  Google Scholar 

  • Arokiyaraj S, Martin S, Perinbam K, Marie AP, Beatrice V (2008) Free radical scavenging activity and HPTLC fingerprint Pterocarpus santalinus L.-an in vitro study. Indian J Sci Technol 1:1–3

    Google Scholar 

  • Arunakumara KKIU, Subasinghe BCWS, Yoon MH (2011) Pterocarpus santalinus Linn. f. (Roth handgun): a review of its botany, uses, phytochemistry and pharmacology. J Korean Soc Appl Biol Chem 54:495–500

    CAS  Google Scholar 

  • Ashidate K, Kawamura M, Mimura D, Tohda H, Miyazaki S et al (2005) Gentisic acid, an aspirin metabolite, inhibits oxidation of low-density lipoprotein and the formation of cholesterol ester hydroperoxides in human plasma. Eur J Pharmacol 513:173–179

    Article  CAS  PubMed  Google Scholar 

  • Azamthulla M, Rajkapoor B, Kavimani S (2015) A review on Pterocarpus santalinus Linn. f. World J Pharm Res 4(2):282–292

    Google Scholar 

  • Balaraju K, Arokiyaraj S, Agastian P, Perinbam K, Ignacimuthu S (2008) Antimicrobial activity of leaf extracts of Pterocarpus santalinus L. (Fabaceae). J Pure Appl Microbiol 2(1):161–164

    Google Scholar 

  • Bhagyaraj A (2017) Red Sanders invisible activities in Chittoor district: a case study. Int J Adv Res 5(9):1073–1080

    Article  Google Scholar 

  • Biswas TK, Narayan ML, Mukherjee B (2004) Wound healing potential of Pterocarpus santalinus Linn.f.: a pharmacological evaluation. Int J Low Extrem Wounds 3:143–150

    Article  PubMed  Google Scholar 

  • Bulle S, Reddy VD, Hebbani AV, Padmavathi P, Challa C, Puvvada PK, Repalle E, Nayakanti D, Narasimhulu CA, Nallanchakravarthula V (2016) Nephro-protective action of P. santalinus against alcohol-induced biochemical alterations and oxidative damage in rats. Biomed Pharmacother 84:740–746

    Article  CAS  PubMed  Google Scholar 

  • Chattopadhyay SK, Kumar TRS, Maulik PR, Srivastava S, Garga A (2003) Absolute configuration and anticancer activity of taxiresinol and related lignans of Taxus wallichiana. Bioorg Med Chem 11:4945–4948

    Article  CAS  PubMed  Google Scholar 

  • Cho JY, Park J, Kim PS, Yoo ES, Baik KU, Park MH (2001) Savinin a lignin from Pterocarpus santalinus inhibits tumor necrosis factor-alpha production and T-cell proliferation. Biol Pharm Bull 24:167–174

    Article  CAS  PubMed  Google Scholar 

  • Dey SK, Chattopadhay S, Masanta NC (2014) Antimicrobial activities of some medicinal plants of red and laterite zone of West Bengal, India. World J Pharm Pharm Sci 3:719–734

    Google Scholar 

  • Dhanabal P, Kannan SE, Bhojraj S (2007) Protective and therapeutic effects of the Indian medicinal plant Pterocarpus santalinus on D-galactosamine-induced liver damage. Asian J Trad Med 2:51–57

    Google Scholar 

  • Dhande PP, Gupta AO, Jain S, Dawane JS (2017) Anti-inflammatory and analgesic activities of topical formulations of Pterocarpus santalinus powder in rat model of chronic inflammation. J Clin Diagn Res 11(7):FF01–FF04

    PubMed  PubMed Central  Google Scholar 

  • Ding RB, Tian K, He CW, Jiang Y, Wang YT, Wan JB (2012) Herbal medicines for the prevention of alcoholic liver diseases. J Ethn Pharm 144:457–465

    Google Scholar 

  • Donald PB (2000) Medicinal plants and phytomedicines. Linking plant biochemistry and physiology to human health plant. J Physiol 124:507–514

    Google Scholar 

  • Donga S, Moteriya P, Chanda S (2017a) Evaluation of antimicrobial and synergistric antimicrobial properties of Pterocarpus santalinus. Asian J Pharm Clin Res 10(11):204–209

    Article  CAS  Google Scholar 

  • Donga S, Pande J, Moteriya P, Chanda S (2017b) In vitro cytotoxicity of leaf, stem, bark of Pterocarpus santalinus Linn.f. Phamacogn. Phytochemistry 6(4):297–305

    CAS  Google Scholar 

  • Duke’s Phytochemical and Ethno Botanical Databases. http://www.ars-grin.gov/cgi-bin/duke/farmacy2.pl. Viewed 8th June 2015

  • Faremi TY, Suru SM, Fafunso MA, Obioha UE (2008) Hepato-protective potentials of Phyllanthus amarus against ethanol-induced oxidative stress in rats. Food Chem Toxicol 46:2658–2664

    Article  CAS  PubMed  Google Scholar 

  • Gao W, Lin P, Hwang E, Wang Y, Yan Z, Ngo HTT, Yi TH (2017) Pterocarpus santalinus L. regulated ultraviolet B irradiation-induced procollagen reduction and matrix metalloproteinases expression through activation of TGF-β/Smad and inhibition of the MAPK/AP-1 pathway in normal human dermal fibroblasts. Photochem Photobiol. https://doi.org/10.1111/php.12835. [Epub ahead of print]

    Article  PubMed  Google Scholar 

  • Gopinath K, Gowri S, Arumugam A (2013) Phytosynthesis of silver nanoparticles using Pterocarpus santalinus leaf extract and their antibacterial properties. J Nanostruct Chem 3:68–85

    Article  Google Scholar 

  • Halim ME, Misra A (2011) The effect of aqueous extract of Pterocarpus santalinus heartwood and vitamin E supplementation in streptozotocin-induced diabetic rats. J Med Plants Res 5:398–409

    Google Scholar 

  • Haschek WM, Wallig MA, Rousseaux C (2010) Fundamentals of toxicologic pathology. Academic, San Diego

    Google Scholar 

  • Hridya H, Amrita A, Mohan S, Gopalakrishnan M, Dakshinamurthy TK, Doss GP, Siva R (2016) Functionality study of santalin as tyrosinase inhibitor: a potential depigmentation agent. Photochem Photobiol 86:383–389

    CAS  Google Scholar 

  • Huang WY, Cai YZ, Zhang Y (2009) Natural phenolic compounds from medicinal herbs and dietary plants: potential use for cancer prevention. Nutr Cancer 62(1):1–20. https://doi.org/10.1080/01635580903191585

    Article  CAS  Google Scholar 

  • Itoh A, Isoda K, Kondoh M, Kawase M, Kobayashi M, Tamesada M, Yagi K (2009) Hepatoprotective effect of syringic acid and vanillic acid on concanavalin A-induced liver injury. Biol Pharm Bull 32:1215–1219

    Article  CAS  PubMed  Google Scholar 

  • Itoh A, Isoda K, Kondoh M, Kawase M, Watari A, Kobayashi M, Tamesada M, Yagi K (2010) Hepatoprotective effect of syringic acid and vanillic acid on CCl4-induced liver injury. Biol Pharm Bull 33:983–987

    Article  CAS  PubMed  Google Scholar 

  • Jadhav J, Mane A, Kanase A (2012) Stimulatory effect of Pterocarpus santalinus on vasculogenesis in chick chorioallantoic membrane (CAM). J Pharm Res 5:208–211

    Google Scholar 

  • Kayser O, Kiderlen AF, Folkens U, Kolodziej H (1998) In vitro leishmanicidal activity of aurones. Planta Med 65:316–319

    Article  Google Scholar 

  • Kayser O, Kiderlen AF, Brun B (2001) In vitro activity of aurones against Plasmodium falciparum strains K1 and NF54. Planta Med 67:718–721

    Article  CAS  PubMed  Google Scholar 

  • Kirtikar KR, Basu BD (2012) Indian medicinal plants. Biogreen Books, New Delhi

    Google Scholar 

  • Kondeti VK, Rao BK, Maddirala DR, Thur SKM, Fatima SS, Kasetti RB, Rao CA (2010) Effect of Pterocarpus santalinus bark, on blood glucose, serum lipids, plasma insulin and hepatic carbohydrate metabolic enzymes in streptozotocin-induced diabetic rats. Food Chem Toxicol 48:1281–1287

    Article  CAS  PubMed  Google Scholar 

  • Krishnamoorthy P, Stella J, Mohamed AJ, Anand M (2011) Radical scavenging and antibacterial evaluation of Pterocarpus santalinus leaf in-vitro study. Int J Pharmacol Sci Res 2:1204–1208

    Google Scholar 

  • Krishnaveni KS, Srinivasa Rao JV (2000) A new isoflavone glucoside from Pterocarpus santalinus. J Asian Nat Prod Res 2(3):219–223

    Article  CAS  PubMed  Google Scholar 

  • Kumar D (2011) Anti-inflammatory, analgesic, and antioxidant activities of methanolic wood extract of Pterocarpus santalinus L. J Pharmacol Pharmacother 2:200–202

    Article  PubMed  PubMed Central  Google Scholar 

  • Kwon HJ, Hong YK, Kim KH, Han CH, Cho SH, Choi JS, Kim BW (2006) Methanolic extract of Pterocarpus santalinus induces apoptosis in Hela cells. J Ethnopharmacol 105:229–234

    Article  CAS  PubMed  Google Scholar 

  • Lokesh T, Sarada B, Swarnalatha K, Kareem MA, Varadacharyulu NC (2016) Antihaemolytic activity of phytochemical aqueous extracts of Pterocarpus santalinus and Phyllanthus emblica in red blood cells of human subjects receiving chronic alcohol and cigarette smoking. Int J Pharm Sci Res 7(9):3857–3864

    CAS  Google Scholar 

  • Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJ (2006) Global burden of disease and risk factors. Oxford University Press, New York

    Book  Google Scholar 

  • Manjunatha BK (2006a) Antibacterial activity of Pterocarpus santalinus. Indian J Pharm Sci 68:115–116

    Article  CAS  Google Scholar 

  • Manjunatha BK (2006b) Hepatoprotective activity of Pterocarpus santalinus L. f., an endangered plant. Indian J Pharmacol 38:25–28

    Article  Google Scholar 

  • Manjunatha BK, Amit R, Priyadarshini P, Paul K (2010) Lead findings from Pterocarpus santalinus with hepatoprotective potentials through in silico methods. Int J Pharma Sci Res 7:265–270

    Google Scholar 

  • Mena S, Rodríguez ML, Ponsoda X, Estrela JM, Jatteela M et al (2012) Pterostilbene-induced tumor cytotoxicity: a lysosomal membrane permeabilization-dependent mechanism. PLoS One 7:e44524

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mishra MP, Padhy RN (2013) In Vitro antibacterial efficacy of 21 Indian timber-yielding plants against multidrug-resistant bacteria causing urinary tract infection. Osong Pub Health Res Perspect 4:347–357

    Article  Google Scholar 

  • Mohandass G, Devi KS, Devanesan (2010) Antifungal activity of Pterocarpus santalinus, an in vitro study. Biomed Pharmacol J 3(1):107–110

    Google Scholar 

  • Nagaraju N, Rao KN (1989) Folk medicine for diabetes from Rayalaseema of Andhra Pradesh. Anc Sci Life 9:31–35

    CAS  PubMed  PubMed Central  Google Scholar 

  • Nagaraju N, Prasad M, Gopalakrishna G, Rao KN (1991) Blood sugar lowering effect of Pterocarpus santalinus (Red Sanders) wood extract in different rat models. Int J Pharmacogn 29:141–144

    Article  Google Scholar 

  • Narayan S, Devi RS, Srinivasan P, Devi CSS (2005) Pterocarpus santalinus: a traditional herbal drug as a protectant against ibuprofen induced gastric ulcers. Phytother Res 19:958–962

    Article  PubMed  Google Scholar 

  • Narayan S, Veeraraghavan M, Devi CS (2007a) Pterocarpus santalinus: an in vitro study on its anti-Helicobacter pylori effect. Phytother Res 21:190–193

    Article  PubMed  Google Scholar 

  • Narayan S, Devi RS, Shyamala Devi CS (2007b) Role of Pterocarpus santalinus against mitochondrial dysfunction and membrane lipid changes induced by ulcerogens in rat gastric mucosa. Chem Biol Interact 170:67–75

    Article  CAS  PubMed  Google Scholar 

  • Padmalatha K, Prasad MNV (2006) Pterocarpus santalinus L.f. and P. marsupium Roxb. – potential source of phytomedicines. In: Sharma RK, Arora R (eds) Herbal drugs: a twenty first century perspectives. Jaypee Brothers, Medicinal Publishers, New Delhi, pp 450–459

    Google Scholar 

  • Panayi GS, Lanchbury JS, Kingsley GH (1992) The importance of the T cell in initiating and maintaining the chronic synovitis of rheumatoid arthritis. Arthritis Rheum 35:729–735

    Article  CAS  PubMed  Google Scholar 

  • Parrotta JA (2001) Healing plants of peninsular India. CABI Publications, Wallingford

    Book  Google Scholar 

  • Prasad SJ, Menon JM, Vijil VV, Aswathi PS, Nimitha KN, Athira L, Vijayalakshmi SV, Sruthi PS, Sughi S, Kurien NK (2016) Evaluation of anti-melanogenic activity if Pterocarpus santalinus L. using bacterial system. Biotech. Res 2(2):58–60

    Google Scholar 

  • Pullaiah T (2006) Encyclopaedia of world medicinal plants. Regency Publications, New Delhi

    Google Scholar 

  • Ramabrahmam V, Sujatha (2016) Red Sanders in Rayalaseema region of Andhra Pradesh: importance to commercial & medicinal value. IOSR J Pharm Biol Sci 11(1):57–60

    Google Scholar 

  • Rao KB, Giri R, Kesavulu MM, Apparao C (2001) Effect of oral administration of bark extracts of Pterocarpus santalinus on blood glucose level in experimental animals. J Ethnopharmacol 74:69–74

    Article  Google Scholar 

  • Reddy OSK (2018) Red Sanders – Pterocarpus santalinus – Rakta chandan – The Red Gold – Green wealth – An opportunity for Indian Farming community – Let’s explore. https://www.linkedin.com/pulse/red-sanders-gold-green-wealth-future-generations-indian-osk-reddy/

  • Reddy L, Reddy G, Reddy RS, Reddy S, Reddy J (2006) Characterization of red sandalwood by ICP-MS analysis, optical absorption and EPR spectroscopic methods. J Rad Eff Defects Solids 161(9):537–547

    Article  CAS  Google Scholar 

  • Riche DM, Riche KD, Blackshear CT et al (2014) Pterostilbene on metabolic parameters: a randomized, double-blind, and placebo-controlled trial. J Evid Based Complement Altern Med. https://doi.org/10.1155/2014/459165

    Article  Google Scholar 

  • Rimando AM, Nagmani R, Feller DR, Yokoyama W (2005) Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor alpha-isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamsters. J Agric Food Chem 53:3403–3407

    Article  CAS  PubMed  Google Scholar 

  • Sandra A, Shenoi SD, Srinivas CR (1996) Allergic contact dermatitis from red sandalwood (Pterocarpus santalinus). Contact Dermatitis 34(1):69

    Article  CAS  PubMed  Google Scholar 

  • Saradamma B, Reddy VD, Padmavathi P, Paramahamsa M, Varadacharyulu N (2016) Modulatory role of Pterocarpus santalinus against alcohol-induced liver oxidative/nitrosative damage in rats. Biomed Pharmacother 83:1057–1063

    Article  Google Scholar 

  • Shankaranarayana KH, Theagarajan KS (2000) Antimicrobial properties of red sanders extracts. Wood News 8(4):25–26

    Google Scholar 

  • Soundararajan V, Ravi Kumar G, Murugesan K, Chandrashekar BS (2016) A review on red sanders (Pterocarpus santalinus Linn.f.)-Phytochemistry and pharmacological importance. World J Pharm Pharm Sci 5(6):667–689

    CAS  Google Scholar 

  • Suanarunsawat T, Boonnak T, Ayutthaya WD, Thirawarapan S (2010) Anti-hyperlipidemic and cardioprotective effects of Ocimum sanctum L. fixed oil in rats fed a high fat diet. J Basic Clin Physiol Pharmacol 2:387–400

    Google Scholar 

  • Sultana N, Akhter M, Khatoon Z (2010) Nematicidal natural products from the aerial parts of Rubus niveus. Nat Prod Res 24:407–415

    Article  CAS  PubMed  Google Scholar 

  • Ullah MF, Khan MW (2008) Food as medicine: potential therapeutic tendencies of plant derived polyphenolic compounds. Asian Pac J Cancer Prev 9:187–195

    PubMed  Google Scholar 

  • Vandita P, Amin N, Khyati P, Monisha K (2013) Effect of phytochemical constituents of Ricinus communis, Pterocarpus santalinus, Terminalia bellerica on antibacterial, antifungal and cytotoxic activity. Int J Toxicol Pharm Res 5(2):47–54

    Google Scholar 

  • Wu SF, Chang FR, Wang SY, Hwang TL, Lee CL, Chen SL, Wu CC, Wu YC (2011a) Anti-inflammatory and cytotoxic neoflavonoids and benzofurans from Pterocarpus santalinus. J Nat Prod 74:989–996

    Article  CAS  PubMed  Google Scholar 

  • Wu SF, Chang FR, Wang SY, Hwang TL, Lee CL, Chen SL, Wu CC, Wu YC (2011b) Bioactive components from the heartwood of Pterocarpus santalinus. J Bioorg Med Chem Lett 21:5630–5632

    Article  CAS  Google Scholar 

  • Yamauchi S, Hayashi Y, Nakashima Y, Kirikihira T, Yamada K, Masuda T (2005) Effect of benzylic oxygen on the antioxidant activity of phenolic lignans. J Nat Prod 68:1459–1470

    Article  CAS  PubMed  Google Scholar 

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Pullaiah, T., Damodara Reddy, V. (2019). Pharmacology of Red Sanders. In: Pullaiah , T., Balasubramanya , S., Anuradha , M. (eds) Red Sanders: Silviculture and Conservation. Springer, Singapore. https://doi.org/10.1007/978-981-13-7627-6_6

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