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Sample Preparation and the Characterization for Intratracheal Administration

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In Vivo Inhalation Toxicity Screening Methods for Manufactured Nanomaterials

Abstract

This chapter explains how to prepare stable nanomaterial dispersion samples and the characterization techniques. The explanation is focused on practical techniques rather than scientific studies. Several technical terms and definitions are explained and effective lab apparatuses are introduced for the better understanding. First, a standard sample preparation method with the typical experimental conditions is described and several actual nanomaterial examples (TiO2, NiO, SiO2, CeO2, and ZnO) are introduced.

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Acknowledgements

This work is part of the research program “Development of innovative methodology for safety assessment of industrial nanomaterials” supported by the Ministry of Economy, Trade and Industry (METI) of Japan. Most content, figures and table of this chapter are referred to “ Technical Guide to Sample Preparation and Characterization for Equivalence Determination and Assessment of Nanomaterial Toxicity” (written in Japanese) published as a product of the research program.

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Correspondence to Kenji Kawaguchi .

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© 2019 Springer Nature Singapore Pte Ltd.

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Kawaguchi, K., Koga, K., Sasaki, T. (2019). Sample Preparation and the Characterization for Intratracheal Administration. In: Takebayashi, T., Landsiedel, R., Gamo, M. (eds) In Vivo Inhalation Toxicity Screening Methods for Manufactured Nanomaterials. Current Topics in Environmental Health and Preventive Medicine. Springer, Singapore. https://doi.org/10.1007/978-981-13-8433-2_7

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  • DOI: https://doi.org/10.1007/978-981-13-8433-2_7

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-13-8432-5

  • Online ISBN: 978-981-13-8433-2

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