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Molecular Mechanisms of Action and Resistance of Antimalarial Drugs

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Bacterial Adaptation to Co-resistance

Abstract

Drug-resistance in plasmodium parasites is manifested at large scale, putting all the malaria control efforts in vain with an urgent need of complementary strategies. A deeper understanding of mechanism of action of drugs, drug resistance and cross-resistance between drugs will pave a way to design an effective individualized drug for malaria-affected regions. This chapter summarizes the molecular mechanism of all currently available anti-malarial drugs and the factors playing significant role in the development and spread of resistance against the antimalarials.

Authors Juveria Khan and Monika Kaushik have equally contributed to this chapter.

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  1. School of Biotechnology, Jawaharlal Nehru University, New Delhi, India

    Juveria Khan, Monika Kaushik & Shailja Singh

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  1. Central Research Facility, Indian Institute of Technology Kharagpur, Kharagpur, India

    Santi M. Mandal

  2. Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh, India

    Debarati Paul

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Khan, J., Kaushik, M., Singh, S. (2019). Molecular Mechanisms of Action and Resistance of Antimalarial Drugs. In: Mandal, S., Paul, D. (eds) Bacterial Adaptation to Co-resistance. Springer, Singapore. https://doi.org/10.1007/978-981-13-8503-2_14

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