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Nanoparticles as New Emerging Antibacterials: Potentials and Limitations

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Antibacterial Drug Discovery to Combat MDR

Abstract

The use and abuse of antimicrobials have led to the emergence of multi-drug resistant (MDR) bacteria and the spread of resistant organisms and is one of the major global threats for healthcare professionals. Alternatives to conventional antibiotics for combating resistant infections are the need of the hour. Nanotechnology-based drugs offer a ray of hope in the fight against MDR bacteria for patients as well as clinicians. Diverse types of nanomaterials have been synthesized from metallic particles with promising antibacterial activity. Efficacy of these nanomaterials depends on their interactions with bacterial cells and their mechanisms of action differ based on their physico-chemical properties. Development of novel and potent nanoantimicrobials requires in-depth knowledge of the physico-chemical properties of nanoparticles and the biological characteristics of bacteria. However, there is still a long way to go as there are major issues related to the toxicity and stability of nanoparticles. Moreover, the economic feasibility of transferring the technology from bench to bedside needs to be addressed. The present review highlights the antibacterial effects of nanoparticles, their mechanisms of action, factors affecting the activity of NPs and challenges of ongoing and future research.

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Acknowledgement

The authors are grateful to the King Saud University and Aligarh Muslim University for providing research facilities.

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Authors and Affiliations

  1. Department of Food Science and Nutrition, College of Food and Agriculture, King Saud University, Riyadh, Kingdom of Saudi Arabia

    Fohad Mabood Husain & Nasser A. Al-Shabib

  2. Department of Agricultural Microbiology, Faculty of Agricultural Sciences, Aligarh Muslim University, Aligarh, India

    Mohammad Shavez Khan & Iqbal Ahmad

  3. College of Agricultural Sciences, Integral University, Lucknow, Uttar Pradesh, India

    Saba Siddiqui

  4. Microbiology Unit, Central Research Laboratory, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia

    Altaf Khan

  5. Department of Clinical Laboratory Science, College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia

    Mohammed Arshad & Abdullah A. Alyousef

  6. School of Life Sciences, B.S. Abdur Rahman University, Chennai, India

    Mashihur Rahman

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  1. Fohad Mabood Husain
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  2. Mohammad Shavez Khan
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  8. Nasser A. Al-Shabib
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  9. Iqbal Ahmad
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Correspondence to Fohad Mabood Husain .

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Editors and Affiliations

  1. Agricultural Microbiology, Faculty of Agricultural Sciences, Aligarh Muslim University, Aligarh, Uttar Pradesh, India

    Iqbal Ahmad

  2. Institute of Ophthalmology, JN Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India

    Shamim Ahmad

  3. School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA

    Kendra P. Rumbaugh

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Husain, F.M. et al. (2019). Nanoparticles as New Emerging Antibacterials: Potentials and Limitations. In: Ahmad, I., Ahmad, S., Rumbaugh, K. (eds) Antibacterial Drug Discovery to Combat MDR. Springer, Singapore. https://doi.org/10.1007/978-981-13-9871-1_25

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