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Nanomaterials as a Novel Class of Anti-infective Agents that Attenuate Bacterial Quorum Sensing

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Antibacterial Drug Discovery to Combat MDR

Abstract

Excessive and unabated use of antibiotics has led to the emergence of multi-drug resistant (MDR) bacteria. The ineffectiveness of current antibiotic therapy and the slow development of new drugs with novel modes of action have made the task of combating MDR infections even more difficult. The problem of multi-drug resistance among pathogens has prompted the scientific community to look for alternative strategies. One such approach, termed antipathogenic/antivirulence therapy, is considered to be a viable alternative. This strategy is focused on rendering the pathogen ineffective by inhibiting its virulence traits rather than killing it. Since antipathogenic/antivirulence compounds target bacterial virulence, the likelihood of developing resistance is also reduced considerably. The areas of major interest in the antivirulence approach include the inhibition of quorum sensing and biofilm formation. The pioneering discovery of halogenated furanones as quorum sensing inhibitors (QSIs) has prompted the scientific community to search for novel QSIs of both natural and synthetic origin. However, QSIs like furanones are not recommended for human use due to issues related to their toxicity and stability. Recently, researchers across the globe have turned their attention toward nanomaterials as potential anti-infective drugs, targeting QS and biofilm formation. Although there are numerous studies regarding the antibacterial effect of nanoparticles, current reports on the antiquorum sensing and biofilm inhibition properties are still scarce. Therefore, in this article we have made an honest attempt to summarize the reports on the anti-QS properties of nanoparticles and their future as novel anti-infective drugs.

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Acknowledgement

The authors acknowledge the Deanship of Scientific Research and Research Centre, College of Applied Medical Sciences, King Saud University, Riyadh, KSA for funding this research.

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Authors and Affiliations

  1. Department of Food Science and Nutrition, College of Food and Agriculture, King Saud University, Riyadh, Kingdom of Saudi Arabia

    Fohad Mabood Husain & Nasser A. Al-Shabib

  2. Department of Agricultural Microbiology, Faculty of Agricultural Sciences, Aligarh Muslim University, Aligarh, India

    Mohammad Shavez Khan & Iqbal Ahmad

  3. Department of Chemistry, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia

    Rais Ahmad Khan

  4. Center of Excellence in Environmental Studies, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia

    Mohammad Oves

  5. Department of Microbiology and Parasitology, Faculty of Medicine, National Autonomous University of Mexico, Avenida Universidad 3000, Mexico City, Mexico

    Rodolfo García Contreras

  6. Protein Research Chair, Department of Biochemistry, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia

    Mohd Shahnawaz Khan

  7. Department of Clinical Laboratory Science, College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia

    Mohammed Arshad & Abdullah A. Alyousef

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  1. Fohad Mabood Husain
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Correspondence to Fohad Mabood Husain .

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Editors and Affiliations

  1. Agricultural Microbiology, Faculty of Agricultural Sciences, Aligarh Muslim University, Aligarh, Uttar Pradesh, India

    Iqbal Ahmad

  2. Institute of Ophthalmology, JN Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India

    Shamim Ahmad

  3. School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA

    Kendra P. Rumbaugh

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Husain, F.M. et al. (2019). Nanomaterials as a Novel Class of Anti-infective Agents that Attenuate Bacterial Quorum Sensing. In: Ahmad, I., Ahmad, S., Rumbaugh, K. (eds) Antibacterial Drug Discovery to Combat MDR. Springer, Singapore. https://doi.org/10.1007/978-981-13-9871-1_26

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