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Adapting the Foreign Soil: Factors Promoting Tumor Metastasis

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'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine

Abstract

Majority of the deaths associated with cancer are attributed to metastasis. Till now there had been no cure of metastasis. Metastatic cells are usually resistant to conventional radiotherapy and chemotherapeutic agents. Metastasis can occur even after decades of treatment of primary tumor. Insights into the molecular mechanisms promoting metastasis could help in developing novel techniques that will prevent development of metastasis. The chapter discusses the major molecular mechanisms that support metastasis. It highlights the mechanisms involved in metastatic dormancy, immunomodulation, and mechano-transduction and their possible role in establishment of metastasis. It gives in-depth review of tumor microenvironment and how microenvironment plays role in supporting micrometastasis. It also discusses the mechanisms and factors which help the micrometastasis to escape the immune response and develop overt metastasis.

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Author information

Author notes

  1. Shah Rukh Abbas and Maria Shabbir contributed equally with all other contributors.

Authors and Affiliations

  1. Atta Ur Rahman School of Applied Biosciences, NUST, Islamabad, Pakistan

    Ramish Riaz

  2. Pakistan Institute of Medical Sciences, Islamabad, Pakistan

    Ramish Riaz

  3. Department of Industrial Biotechnology, Atta Ur Rahman School of Applied Biosciences, NUST, Islamabad, Pakistan

    Shah Rukh Abbas

  4. Department of Healthcare Biotechnology, Atta Ur Rahman School of Applied Biosciences, NUST, Islamabad, Pakistan

    Maria Shabbir

Authors
  1. Ramish Riaz
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  2. Shah Rukh Abbas
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  3. Maria Shabbir
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Correspondence to Ramish Riaz .

Editor information

Editors and Affiliations

  1. Fatima Jinnah Women University, Rawalpindi, Pakistan

    Nosheen Masood

  2. Fatima Jinnah Women University, Rawalpindi, Pakistan

    Saima Shakil Malik

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Riaz, R., Abbas, S.R., Shabbir, M. (2020). Adapting the Foreign Soil: Factors Promoting Tumor Metastasis. In: Masood, N., Shakil Malik, S. (eds) 'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine. Springer, Singapore. https://doi.org/10.1007/978-981-15-1067-0_8

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