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Alterations in Metabolite-Driven Gene Regulation in Cancer Metabolism

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Cancer Cell Metabolism: A Potential Target for Cancer Therapy

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Abstract

Cancer is the leading cause of mortality among humans globally. Knowing about the etiology underlying the advancement of cancer is imperative for curtailing the monetary and social burden of cancer. In addition to genetic mutations, altered metabolism involved metabolic rewiring is needed in cancer cells to support their high nutritional demand needed for energy generation. Cancer metabolism also refers to the perturbations in biochemical pathways that are reported in tumor cells compared with most of the normal cells. Metabolic impairments in tumor cells are more frequent which include aerobic glycolysis, decreased oxidative phosphorylation, and the accelerated production of biosynthetic intermediates crucial to the proliferative cells for their growth and development. Interruptions in metabolic cascades responsible for fueling energy into the cancer cells for their growth has been observed in most of the cancer forms. These interruptions, in turn, facilitates growth in tumor cells by ceasing biochemical signals used to inhibit tumor initiation, hence eventually increase the metastatic character of the tumor cells. However, the precise mechanisms whereby metabolic pathways contribute to the cancer prognosis remain uncertain. This chapter thus consolidates recent findings regarding cross talk between metabolic alterations and cancer biology. Further, a concrete and deep understanding of this heterogeneity may enable the advancement and optimization of potential therapeutic approaches that target biochemical pathways associated with proliferation of malignant cells.

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Authors and Affiliations

  1. Department of Biotechnology, School of Engineering & Technology, Sharda University, Greater Noida, India

    Saurabh Kumar Jha, Kumari Swati, Niraj Kumar Jha & Parma Nand

  2. Department of Life Science, School of Basic Science and Research (SBSR), Sharda University, Greater Noida, India

    Rahul Yadav, Ankur Sharma, Prabhjot Kaur, Tanaya Gover & Geetika Rawat

  3. Department of Biotechnology, Noida Institute of Engineering & Technology (NIET), Greater Noida, India

    Fahad Khan

  4. Department of Chemistry, SRM University, Modi Nagar, Uttar Pradesh, India

    Neeraj Kumar

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  1. Saurabh Kumar Jha
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  1. Amity Institute of Molecular Medicine & Stem Cell Research (AIMMSCR), Amity University Uttar Pradesh (AUUP), Noida, Uttar Pradesh, India

    Dhruv Kumar

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Jha, S.K. et al. (2020). Alterations in Metabolite-Driven Gene Regulation in Cancer Metabolism. In: Kumar, D. (eds) Cancer Cell Metabolism: A Potential Target for Cancer Therapy. Springer, Singapore. https://doi.org/10.1007/978-981-15-1991-8_10

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