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Directional Cell Migration Guide for Improved Tissue Regeneration

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Bioinspired Biomaterials

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1249 ))

Abstract

The field of tissue regeneration has seen a paradigm shift after one wave of technological innovation after another, which has notably made significant contributions to basic cellular response control and overall tissue regeneration. One particular area that is seeing rekindled interest after technological innovation is managing cell migration toward defects because successful host cell migration from adjacent tissue can accelerate overall regeneration time in tissue defects that are either large in size or irregular in shape. This chapter surveys significant advances on directed cell migration upon topological cues. First, we introduce several examples of patterning and electrospinning technology for guiding directed cell migration, followed by a discussion on approaches to influencing radially aligned topography in pattern or electrospun sheet for overall tissue regeneration.

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Acknowledgment

This work was supported by a grant from the National Research Foundation (NRF) of Korea, which is supported by the Korean government (MEST) (NRF-2017R1D1A1B03031656 to Y.M.S.), and a grant from the Ministry of Trade, Industry and Energy (MOTIE) (Grant No. 10047811 to H.J.C).

Author information

Authors and Affiliations

  1. Department of Nanobiomedical science, Dankook University, Cheonan-si, Chungnam, Republic of Korea

    Young Min Shin & Hee Seok Yang

  2. Institute of Cell & Tissue Engineering and College of Medicine, Catholic University of Korea, Seoul, South Korea

    Heung Jae Chun

Authors
  1. Young Min Shin
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  2. Hee Seok Yang
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  3. Heung Jae Chun
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Corresponding author

Correspondence to Heung Jae Chun .

Editor information

Editors and Affiliations

  1. Institute of Cell & Tissue Engineering and College of Medicine, Catholic University of Korea, Seoul, Korea (Republic of)

    Heung Jae Chun

  2. 3B’s Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, Guimarães, Portugal

    Rui L. Reis

  3. Department of Industrial Engineering and BIOtech Research Center, University of Trento, Trento, Italy

    Antonella Motta

  4. Department of BIN Convergence Technology, Department of Polymer Nano Science & Technology and Polymer BIN Research Center, Jeonbuk National University, Jeonju, Korea (Republic of)

    Gilson Khang

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Shin, Y.M., Yang, H.S., Chun, H.J. (2020). Directional Cell Migration Guide for Improved Tissue Regeneration. In: Chun, H.J., Reis, R.L., Motta, A., Khang, G. (eds) Bioinspired Biomaterials. Advances in Experimental Medicine and Biology, vol 1249 . Springer, Singapore. https://doi.org/10.1007/978-981-15-3258-0_9

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