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Affinity-Based Methods for the Analysis of Emerging Contaminants in Wastewater and Related Samples

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Contaminants in Drinking and Wastewater Sources

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Abstract

The presence of emerging man-made contaminants in wastewater and water sources in the environment is a growing problem worldwide. Affinity chromatography is one approach that has been explored for the detection and analysis of such compounds. This approach is a chromatographic technique in which target analytes are captured based on their selective interactions with a biologically related binding agent that has been immobilized onto a support and placed within a column. Various forms of affinity chromatography have been utilized for the analysis of emerging contaminants in wastewater and the environment. Binding agents such as antibodies, molecularly imprinted polymers, and chiral stationary phases have been employed in this work, with the latter including macrocyclic antibiotics, proteins, and polysaccharide derivatives. Each of these binding agents is considered in this chapter with regards to their applications for emerging contaminants in water. Formats in which these binding agents have been used will also be described, such as off-line or online extraction, chromatographic immunoassays, and methods in which affinity chromatography has been combined with liquid chromatography, gas chromatography, and liquid chromatography-mass spectrometry. Other binding agents, such as aptamers and boronates, will also be briefly described that may be employed in future work with affinity-based separations for the analysis of emerging contaminants in water.

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Abbreviations

Ab:

Antibody

Ag:

Antigen

AGP:

α1-Acid glycoprotein

BSA:

Bovine serum albumin

CBH I:

Cellobiohydrolase I

CSP:

Chiral stationary phase

DLLME:

Dispersive liquid–liquid micro extraction

ELISA:

Enzyme-linked immunosorbent assay

GC:

Gas chromatography

GC-MS:

Gas chromatography coupled to mass spectrometry

HPLC:

High-performance liquid chromatography

IAC:

Immunoaffinity chromatography

IgG:

Immunoglobulin G

K a :

Association equilibrium constant

k a :

Second-order association rate constant

k d :

First-order dissociation rate constant

LC:

Liquid chromatography

LC-MS:

Liquid chromatography coupled to mass spectrometry

LC-MS/MS:

Liquid chromatography coupled to tandem mass spectrometry

LLE:

Liquid–liquid extraction

MIP:

Molecularly imprinted polymer

MMIP:

Magnetic molecularly imprinted polymer

MRM:

Multiple reaction monitoring

RPLC:

Reversed-phase liquid chromatography

SELEX:

Systemic evolution of ligands by exponential enrichment

SPE:

Solid-phase extraction

SPME:

Solid-phase microextraction

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Acknowledgements

This work was supported, in part, through a seed grant from the University of Nebraska Research Council.

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Authors and Affiliations

  1. Department of Chemistry, University of Nebraska, Lincoln, NE, 68588, USA

    Sazia Iftekhar, Susan T. Ovbude & David S. Hage

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  1. Sazia Iftekhar
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  2. Susan T. Ovbude
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  3. David S. Hage
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Correspondence to David S. Hage .

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Editors and Affiliations

  1. Discipline of Earth Sciences, Indian Institute of Technology Gandhinagar, Gandhinagar, Gujarat, India

    Manish Kumar

  2. Water Sciences Laboratory, University of Nebraska–Lincoln, Lincoln, NE, USA

    Daniel D. Snow

  3. Faculty of Geosciences and Civil Engineering, Kanazawa University, Kanazawa, Japan

    Ryo Honda

  4. Discipline of Earth Sciences, Indian Institute of Technology Gandhinagar, Gandhinagar, Gujarat, India

    Santanu Mukherjee

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Iftekhar, S., Ovbude, S.T., Hage, D.S. (2021). Affinity-Based Methods for the Analysis of Emerging Contaminants in Wastewater and Related Samples. In: Kumar, M., Snow, D., Honda, R., Mukherjee, S. (eds) Contaminants in Drinking and Wastewater Sources. Springer Transactions in Civil and Environmental Engineering. Springer, Singapore. https://doi.org/10.1007/978-981-15-4599-3_2

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