Abstract
ABO blood type has been known as a genetic factor which affects the development of gastric cancer. However, the mechanism is still uncertain. There are experimental evidences which suggest the role of ABO blood type in the infection of Helicobacter pylori (H. pylori). Molecular mimicry was shown with Lewis antigens, with which H. pylori can evade the host immune system. Blood group antigens were observed to act as an adhesion molecule onto which H. pylori attach. Nonsecretors compared with secretors lack “decoys”; therefore, nonsecretors are more vulnerable to intruders. These findings can be clues for future studies.
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Oh, S. (2016). Gastric Cancer: ABO Blood Type. In: Kim, N. (eds) Helicobacter pylori. Springer, Singapore. https://doi.org/10.1007/978-981-287-706-2_26
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DOI: https://doi.org/10.1007/978-981-287-706-2_26
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