Abstract
ABO blood type has been known as a genetic factor which affects the development of gastric cancer. However, the mechanism is still uncertain. There are experimental evidences which suggest the role of ABO blood type in the infection of Helicobacter pylori (H. pylori). Molecular mimicry was shown with Lewis antigens, with which H. pylori can evade the host immune system. Blood group antigens were observed to act as an adhesion molecule onto which H. pylori attach. Nonsecretors compared with secretors lack “decoys”; therefore, nonsecretors are more vulnerable to intruders. These findings can be clues for future studies.
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References
Goldman L, Ausiello D. Cecil textbook of internal medicine. 24th ed. Philadelphia: Saunders; 2012.
Harvard School of Public Health. Disease Risk Index 2008. http://www.diseaseriskindex.harvard.edu/update/hccpquiz.pl? lang=english&func=show&quiz=stomach&page=risk_list. Accessed 9 Feb 2015.
Colditz GA, Atwood KA, Emmons K, Monson RR, Willett WC, Trichopoulos D, et al. Harvard report on cancer prevention volume 4: harvard cancer risk index. Cancer Causes Control. 2000;11:477–88.
Clarke CA. Blood group and disease. In: Steiberg AG, editor. Progress in medical genetics, vol. 1. New York: Grunne and Stratton; 1961. p. 81–119.
Edgren G, Hjalgrim H, Rostgaard K, Norda R, Wikman A, Melbye M, et al. Risk of gastric cancer and peptic ulcers in relation to ABO blood type: a cohort study. Am J Epidemiol. 2010;172:1280–5.
Nakao M, Matsuo K, Ito H, Shitara K, Hosono S, Watanabe M, et al. ABO genotype and the risk of gastric cancer, atrophic gastritis, and Helicobacter pylori infection. Cancer Epidemiol Biomarkers Prev. 2011;20:1665–72.
Song HR, Shin MH, Kim HN, Piao JM, Choi JS, Hwang JE, et al. Sex-specific differences in the association between ABO genotype and gastric cancer risk in a Korean population. Gastric Cancer. 2013;16:254–60.
Risch HA, Yu H, Lu L, Kidd MS. ABO blood group, Helicobacter pylori seropositivity, and risk of pancreatic cancer: a case-control study. J Natl Cancer Inst. 2010;102:502–5.
Gates MA, Xu M, Chen WY, Kraft P, Hankinson SE, Wolpin BM. ABO blood group and breast cancer incidence and survival. Int J Cancer. 2012;130:2129–37.
Klein AP, Lindström S, Mendelsohn JB, Steplowski E, Arslan AA, Bueno-de-Mesquita HB, et al. An absolute risk model to identify individuals at elevated risk for pancreatic cancer in the general population. PLoS ONE. 2013;8, e72311.
Lodish H, Berk A, Kaiser CA, Krieger M. Molecular cell biology. 7th ed. New York: W.H. Freeman and Company; 2012.
Daniels G. Human blood groups. 3rd ed. Oxford: Wiley-Blackwell; 2013.
Moran AP. Lipopolysaccharide in bacterial chronic infection: insights from Helicobacter pylori lipopolysaccharide and lipid A. Int J Med Microbiol. 2007;297:307–19.
Moore ME, Borén T, Solnick JV. Life at the margins: modulation of attachment proteins in Helicobacter pylori. Gut Microbes. 2011;2:42–6.
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Oh, S. (2016). Gastric Cancer: ABO Blood Type. In: Kim, N. (eds) Helicobacter pylori. Springer, Singapore. https://doi.org/10.1007/978-981-287-706-2_26
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DOI: https://doi.org/10.1007/978-981-287-706-2_26
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