Skip to main content
SpringerLink
Log in

Nervous System Disorders in Chronic Kidney Disease: Neurocognitive Dysfunction, Depression, and Sleep Disorder

  • Chapter
  • First Online:
Chronic Kidney Disease

  • 2023 Accesses

Abstract

Nervous system disorders, including cognitive impairment, depression, and sleep disorder, are highly prevalent in patients with chronic kidney disease (CKD). The mechanisms leading to the increased prevalence are usually multifaceted. These complications can pose great threat to patients’ health and quality of life, but sometimes could be neglected or unrealized in clinical practice. Therefore, physicians should be aware of the features of these conditions in CKD patients and need to consider performing routine screening tests, especially in those with advanced renal dysfunction. Management of these complications usually requires identification and targeted treatment of reversible underlying causes, general supporting management of CKD, and consultation with specialist in relevant areas.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 129.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Kurella M, Chertow GM, Fried LF, et al. Chronic kidney disease and cognitive impairment in the elderly: the health, aging, and body composition study. J Am Soc Nephrol. 2005;16(7):2127–33.

    Article  Google Scholar 

  2. Miwa K, Tanaka M, Okazaki S, et al. Chronic kidney disease is associated with dementia independent of cerebral small-vessel disease. Neurology. 2014;82(12):1051–7.

    Article  CAS  Google Scholar 

  3. Darsie B, Shlipak MG, Sarnak MJ, Katz R, Fitzpatrick AL, Odden MC. Kidney function and cognitive health in older adults: the Cardiovascular Health Study. Am J Epidemiol. 2014;180(1):68–75.

    Article  Google Scholar 

  4. Murray AM, Tupper DE, Knopman DS, et al. Cognitive impairment in hemodialysis patients is common. Neurology. 2006;67(2):216–23.

    Article  CAS  Google Scholar 

  5. Wolfgram DF, Szabo A, Murray AM, Whittle J. Risk of dementia in peritoneal dialysis patients compared with hemodialysis patients. Perit Dial Int. 2015;35(2):189–98.

    Article  Google Scholar 

  6. Neumann D, Mau W, Wienke A, Girndt M. Peritoneal dialysis is associated with better cognitive function than hemodialysis over a one-year course. Kidney Int. 2018;93(2):430–8.

    Article  Google Scholar 

  7. Hailpern SM, Melamed ML, Cohen HW, Hostetter TH. Moderate chronic kidney disease and cognitive function in adults 20 to 59 years of age: Third National Health and Nutrition Examination Survey (NHANES III). J Am Soc Nephrol. 2007;18(7):2205–13.

    Article  Google Scholar 

  8. Seliger SL, Siscovick DS, Stehman-Breen CO, et al. Moderate renal impairment and risk of dementia among older adults: the Cardiovascular Health Cognition Study. J Am Soc Nephrol. 2004;15(7):1904–11.

    Article  Google Scholar 

  9. Khatri M, Nickolas T, Moon YP, et al. CKD associates with cognitive decline. J Am Soc Nephrol. 2009;20(11):2427–32.

    Article  CAS  Google Scholar 

  10. Kurella Tamura M, Wadley V, Yaffe K, et al. Kidney function and cognitive impairment in US adults: the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study. Am J Kidney Dis. 2008;52(2):227–34.

    Article  Google Scholar 

  11. Freedman BI, Sink KM, Hugenschmidt CE, et al. Associations of early kidney disease with brain magnetic resonance imaging and cognitive function in African Americans with type 2 diabetes mellitus. Am J Kidney Dis. 2017;70(5):627–37.

    Article  Google Scholar 

  12. Kurella M, Mapes DL, Port FK, Chertow GM. Correlates and outcomes of dementia among dialysis patients: the Dialysis Outcomes and Practice Patterns Study. Nephrol Dial Transplant. 2006;21(9):2543–8.

    Article  Google Scholar 

  13. Rakowski DA, Caillard S, Agodoa LY, Abbott KC. Dementia as a predictor of mortality in dialysis patients. Clin J Am Soc Nephrol. 2006;1(5):1000–5.

    Article  Google Scholar 

  14. Cohen LM, Ruthazer R, Moss AH, Germain MJ. Predicting six-month mortality for patients who are on maintenance hemodialysis. Clin J Am Soc Nephrol. 2010;5(1):72–9.

    Article  Google Scholar 

  15. Griva K, Stygall J, Hankins M, Davenport A, Harrison M, Newman SP. Cognitive impairment and 7-year mortality in dialysis patients. Am J Kidney Dis. 2010;56(4):693–703.

    Article  Google Scholar 

  16. Drew DA, Weiner DE, Tighiouart H, et al. Cognitive function and all-cause mortality in maintenance hemodialysis patients. Am J Kidney Dis. 2015;65(2):303–11.

    Article  Google Scholar 

  17. Yaffe K, Lindquist K, Shlipak MG, et al. Cystatin C as a marker of cognitive function in elders: findings from the health ABC study. Ann Neurol. 2008;63(6):798–802.

    Article  CAS  Google Scholar 

  18. Yeh YC, Huang MF, Liang SS, et al. Indoxyl sulfate, not p-cresyl sulfate, is associated with cognitive impairment in early-stage chronic kidney disease. Neurotoxicology. 2016;53:148–52.

    Article  CAS  Google Scholar 

  19. Kurella Tamura M, Yaffe K. Dementia and cognitive impairment in ESRD: diagnostic and therapeutic strategies. Kidney Int. 2011;79(1):14–22.

    Article  Google Scholar 

  20. Marsh JT, Brown WS, Wolcott D, et al. rHuEPO treatment improves brain and cognitive function of anemic dialysis patients. Kidney Int. 1991;39(1):155–63.

    Article  CAS  Google Scholar 

  21. Temple RM, Deary IJ, Winney RJ. Recombinant erythropoietin improves cognitive function in patients maintained on chronic ambulatory peritoneal dialysis. Nephrol Dial Transplant. 1995;10(9):1733–8.

    CAS  PubMed  Google Scholar 

  22. Gupta A, Lepping RJ, Yu AS, et al. Cognitive function and white matter changes associated with renal transplantation. Am J Nephrol. 2016;43(1):50–7.

    Article  CAS  Google Scholar 

  23. Kramer L, Madl C, Stockenhuber F, et al. Beneficial effect of renal transplantation on cognitive brain function. Kidney Int. 1996;49(3):833–8.

    Article  CAS  Google Scholar 

  24. Dixon BS, VanBuren JM, Rodrigue JR, et al. Cognitive changes associated with switching to frequent nocturnal hemodialysis or renal transplantation. BMC Nephrol. 2016;17:12.

    Article  Google Scholar 

  25. Palmer S, Vecchio M, Craig JC, et al. Prevalence of depression in chronic kidney disease: systematic review and meta-analysis of observational studies. Kidney Int. 2013;84(1):179–91.

    Article  Google Scholar 

  26. Tsai YC, Chiu YW, Hung CC, et al. Association of symptoms of depression with progression of CKD. Am J Kidney Dis. 2012;60(1):54–61.

    Article  Google Scholar 

  27. Vazquez I, Valderrabano F, Fort J, et al. Psychosocial factors and health-related quality of life in hemodialysis patients. Qual Life Res. 2005;14(1):179–90.

    Article  Google Scholar 

  28. Sayin A, Mutluay R, Sindel S. Quality of life in hemodialysis, peritoneal dialysis, and transplantation patients. Transplant Proc. 2007;39(10):3047–53.

    Article  CAS  Google Scholar 

  29. Kovacs AZ, Molnar MZ, Szeifert L, et al. Sleep disorders, depressive symptoms and health-related quality of life—a cross-sectional comparison between kidney transplant recipients and waitlisted patients on maintenance dialysis. Nephrol Dial Transplant. 2011;26(3):1058–65.

    Article  Google Scholar 

  30. Kimmel PL, Peterson RA, Weihs KL, et al. Psychosocial factors, behavioral compliance and survival in urban hemodialysis patients. Kidney Int. 1998;54(1):245–54.

    Article  CAS  Google Scholar 

  31. Devins GM, Mann J, Mandin H, et al. Psychosocial predictors of survival in end-stage renal disease. J Nerv Ment Dis. 1990;178(2):127–33.

    Article  CAS  Google Scholar 

  32. Lopes AA, Bragg J, Young E, et al. Depression as a predictor of mortality and hospitalization among hemodialysis patients in the United States and Europe. Kidney Int. 2002;62(1):199–207.

    Article  Google Scholar 

  33. Zalai D, Szeifert L, Novak M. Psychological distress and depression in patients with chronic kidney disease. Semin Dial. 2012;25(4):428–38.

    Article  Google Scholar 

  34. Merlino G, Piani A, Dolso P, et al. Sleep disorders in patients with end-stage renal disease undergoing dialysis therapy. Nephrol Dial Transplant. 2006;21(1):184–90.

    Article  Google Scholar 

  35. De Santo RM, Bartiromo M, Cesare MC, Di Iorio BR. Sleeping disorders in early chronic kidney disease. Semin Nephrol. 2006;26(1):64–7.

    Article  Google Scholar 

  36. Weisbord SD, Fried LF, Mor MK, et al. Renal provider recognition of symptoms in patients on maintenance hemodialysis. Clin J Am Soc Nephrol. 2007;2(5):960–7.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Centre for Kidney Disease, Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China

    Wenjin Liu

Authors
  1. Wenjin Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Wenjin Liu .

Editor information

Editors and Affiliations

  1. Centre for Kidney Disease, Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China

    Junwei Yang

  2. Centre for Kidney Disease, Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China

    Weichun He

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Liu, W. (2020). Nervous System Disorders in Chronic Kidney Disease: Neurocognitive Dysfunction, Depression, and Sleep Disorder. In: Yang, J., He, W. (eds) Chronic Kidney Disease. Springer, Singapore. https://doi.org/10.1007/978-981-32-9131-7_13

Download citation

  • DOI: https://doi.org/10.1007/978-981-32-9131-7_13

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-32-9130-0

  • Online ISBN: 978-981-32-9131-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation