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The Role of Tau in the Post-synapse

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Tau Biology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1184))

Abstract

It is well documented that tauopathy is involved in various forms of neurodegenerative disease. However, there is a huge gap in terms of our understanding of the neurophysiological roles of tau, and how these can be aberrantly regulated by pathological processes. Tau is enriched in the axon but is also localized to synapses. The finding of synaptically localised tau has undoubtedly created more questions than it has answered. What is the physiological role of tau at the synapse? Whether and how does tau interact with and effect other synaptic proteins to mediate this function? Are these effects regulated by post-translational modifications of tau, such as phosphorylation? Such questions require significant attention from the scientific community if we are to resolve this critical aspect of tau biology. This chapter will describe our current understanding of synaptic tau and its functions and illuminate the numerous remaining challenges in this evolving research area.

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Abbreviations

Aβ:

Amyloid beta

AD:

Alzheimer’s disease

AMPAR:

α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor

GSK-3:

Glycogen synthase kinase-3

LTD:

Long-term depression

LTP:

Long-term potentiation

NMDAR:

N-methyl-D-aspartate receptor

pTau:

Phosphorylated Tau

Tau:

Microtubule associated protein tau

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Authors and Affiliations

  1. Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Bristol Medical School, Faculty of Health Sciences, University of Bristol, Bristol, UK

    Philip Regan

  2. UK-Dementia Research Institute, Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King’s College London, London, UK

    Kwangwook Cho

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  1. Philip Regan
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Correspondence to Kwangwook Cho .

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Editors and Affiliations

  1. Department of Life Sciences, Gakushuin University, Tokyo, Japan

    Akihiko Takashima

  2. Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA

    Benjamin Wolozin

  3. University of Lille, INSERM, CHU-Lille, Alzheimer & Tauopathies, LabEx DISTALZ, Lille, France

    Luc Buee

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Regan, P., Cho, K. (2019). The Role of Tau in the Post-synapse. In: Takashima, A., Wolozin, B., Buee, L. (eds) Tau Biology. Advances in Experimental Medicine and Biology, vol 1184. Springer, Singapore. https://doi.org/10.1007/978-981-32-9358-8_10

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