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A Novel Hybrid Magnetoacoustic Measurement Method for Breast Cancer Detection

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Advances in Medical Diagnostic Technology

Part of the book series: Lecture Notes in Bioengineering ((LNBE))

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Abstract

Breast cancer is the most common cancer in women worldwide. It is a disease of uncontrolled breast cells growth, in which the cells acquire genetic alteration, causing them to proliferate more aggressively as compared to normal tissue development. In current medical practice, the gold standard for breast cancer screening is mammography. However, its usage is unsafe as it exposes patient to ionizing radiation and it is less comfortable due to the need for breast compression. Another available option for breast screening is ultrasound. To date, ultrasound is an important adjunct modality to mammography regardless of its low sensitivity in detecting small cancers from normal tissues due to overlapping ultrasonic characteristics of these tissues. To address this problem, a hybrid magnetoacoustic measurement method (HMM) that combines ultrasound and magnetism for the simultaneous assessment of bioelectric and acoustic profiles of breast tissue is proposed. Previous studies have shown that in cancerous tissue, changes in ultrasonic characteristics occur due to uncontrolled cell multiplication, excessive accumulation of protein in stroma, and enhancement of capillary density. Additionally, changes in conductivity also occur due to the increase in cellular water and electrolyte content, as well as membrane permeability due to increased metabolic requirements. In HMM, the interaction between the ultrasound wave and the magnetic field in the breast tissue results in Lorentz force. This produces a magnetoacoustic voltage output, which is proportional to breast tissue conductivity. Simultaneously, the ultrasound wave is sensed back by the ultrasound receiver for tissue acoustic evaluation. At the end of this study, ultrasound wave characterization results showed that normal breast tissue experienced higher attenuation compared with cancerous tissue. The mean magnetoacoustic voltage results for normal tissue were lower than the cancerous tissue group. This demonstrates that the combination of acoustic and bioelectric measurements appears to be a promising approach for diagnosis.

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Authors and Affiliations

  1. Universiti Teknologi Malaysia, Level 3, V01, Block A, Satellite Building, Skudai-Johor, Malaysia

    Maheza Irna Mohamad Salim

  2. Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, Level 3, V01, Block A, Satellite Building, Skudai-Johor, Malaysia

    Nugraha Priya Utama & Yin Mon Myint

  3. Faculty of Biosciences and Medical Engineering, IJN-UTM Cardiovascular Engineering Center, Universiti Teknologi Malaysia, Skudai-Johor, Malaysia

    Eko Supriyanto

  4. Biomedical Engineering Department, University Malaya, Kuala Lumpur, Malaysia

    Khin Wee Lai

  5. MIMOS Berhad, Technology Park Malaysia, 57000, Kuala Lumpur, Malaysia

    Yan Chai Hum

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  1. Maheza Irna Mohamad Salim
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  2. Nugraha Priya Utama
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  3. Eko Supriyanto
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  4. Khin Wee Lai
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Mohamad Salim, M.I., Utama, N.P., Supriyanto, E., Lai, K.W., Hum, Y.C., Myint, Y.M. (2014). A Novel Hybrid Magnetoacoustic Measurement Method for Breast Cancer Detection. In: Advances in Medical Diagnostic Technology. Lecture Notes in Bioengineering. Springer, Singapore. https://doi.org/10.1007/978-981-4585-72-9_6

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