Skip to main content
SpringerLink
Log in

The relationship between structure and biological activity: Some fundamental aspects

  • Conference paper
  • First Online:
Ergebnisse der physiologie biologischen chemie und experimentellen pharmakologie

Part of the book series: Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie ((ERGEBPHYSIOL,volume 49))

  • 28 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Adam, N. K.: The physics and chemistry of surfaces, 3rd edit. Oxford 1941.

    Google Scholar 

  2. Adcock, E. M.: The permeability of gregarine protozoa from the gut of the mealworm. J. of Exper. Biol. 17, 449 (1940).

    Google Scholar 

  3. Albert, A.: Therapeutic interference. Report of 3rd Symposium of the Society of Experimental Biology. Selective Toxicity: Cambridge Univ. Press 1949.

    Google Scholar 

  4. —: Quantitative studies of the avidity of naturally occurring substances for trace metals. I. Amino-acids having only two ionizing groups. Biochemic. J. 47, 531 (1950).

    CAS  Google Scholar 

  5. — Selective toxicity. London: Methuen & Co., New York: Wiley 1951.

    Google Scholar 

  6. — The acridines, their preparation, properties and uses. London: Edward Arnold & Co., New York: Longmans, Green 1951.

    Google Scholar 

  7. — Ionization, pH and biological activity. Pharmacol. Rev. 4, 136 (1952).

    PubMed  CAS  Google Scholar 

  8. — Quantitative studies of the avidity of naturally occurring substances for trace metals. II. Amino-acids having three ionizing groups. Biochemic. J. 50, 690 (1952).

    CAS  Google Scholar 

  9. Albert, A.: Quantitative studies of the avidity of naturally occurring substances for trace metals. III. Biochemic. J. 54, 646 (1953).

    CAS  Google Scholar 

  10. — Antivitamins, antimetabolites and chemotherapy. Brit. Med. Bull. 12, 67 (1956).

    PubMed  CAS  Google Scholar 

  11. — The mode of action of isoniazid. Nature (Lond.) 177, 525 (1956).

    CAS  Google Scholar 

  12. Albert, A.: Concentration quenching. Pharmacol. Rev. (in preparation).

    Google Scholar 

  13. —, J. E. Falk, and S. D. Rubbo: Antibacterial action of arsenic. Nature (Lond.) 153, 712 (1944).

    CAS  Google Scholar 

  14. —, M. Gibson, and S. D. Rubbo: The influence of chemical constitution on antibacterial activity. Part VI. The bactericidal action of 8-hydroxyquinoline (oxine). Brit. J. Exper. Path. 34, 119 (1953).

    CAS  Google Scholar 

  15. —Albert, A., and R. J. Goldacre: The ionization of acridine bases. J. Chem. Soc. Lond. 1946, 706.

    Google Scholar 

  16. —, A. Hampton, F. R. Selbie and R. D. Simon: The influence of chemical constitution on antibacterial activity. Part VII. The site of action of 8-hydroxyquinoline (oxine). Brit. J. Exper. Path. 35, 75 (1954).

    CAS  Google Scholar 

  17. —, and C. W. Rees: The avidity of tetracyclines for the cations of metals. Nature (Lond.) 177, 433 (1956).

    CAS  Google Scholar 

  18. Albert, A., and C. W. Rees, and A. J. H. Tomlinson: The influence of chemical constitution on antibacterial activity. Part VIII. 2-mercaptopyridine-N-oxide, and some general observations on metal-binding agents. Brit. J. Exper. Path. 1956.

    Google Scholar 

  19. —, S. D. Rubbo and M. I. Burvill: The influence of chemical constitution on antibacterial activity. Part IV. A survey of heterocyclic bases, with special reference to benzquinolines, phenanthridines and benzacridines. Brit. J. Exper. Path. 30, 159 (1949).

    CAS  Google Scholar 

  20. —, and R. J. Goldacre: Correlation of basicity and antiseptic action in an acridine series. Nature (Lond.) 147, 332 (1941).

    CAS  Google Scholar 

  21. —, and B. G. Balfour: The influence of chemical constitution on antibacterial activity. Part III. A study of 8-hydroxyquinoline (oxine) and related compounds. Brit. J. Exper. Path. 28, 69 (1947).

    CAS  Google Scholar 

  22. —, M. Davey and J. Stone: The influence of chemical constitution on antibacterial activity. Part II. A general survey of the acridine series. Brit. J. Exper. Path. 26, 160 (1945).

    CAS  Google Scholar 

  23. Aldridge, W. N., and A. N. Davison: The inhibition of erythrocyte cholinesterase by tri-esters of phosphoric acid. Biochemic. J. 51, 62 (1952); Aldridge, W. N.: Anticholinesterases. Inhibition of cholinesterase by organo-phosphorus compounds and reversal of this reaction: mechanisms involved. Chem. a. Ind. 1954, 473.

    CAS  Google Scholar 

  24. Anker, R. M., and A. H. Cook: Experiments in the piperidine series. Part III. J. Chem. Soc. Lond. 1946, 58.

    Google Scholar 

  25. Axelrod, J., L. Aronow and B. B. Brodie: The physiological disposition and biotransformation of dibenamine and a method for its estimation in biological tissues. J. of Pharmacol. 106, 166 (1952).

    CAS  Google Scholar 

  26. Bacq, Z., A. Herve et P. Fischer: Rayons X et agents de chelation. Bull. Acad. royale Méd. Belg. 18, 226 (1953).

    CAS  Google Scholar 

  27. Badger, G. M.: Molecular asymmetry and biological activity. Nature (Lond.) 159, 194 (1947).

    CAS  Google Scholar 

  28. Baur, E., u. H. Preis: Über Oxydationshemmung von Cystein und Ascorbinsäure. Z. physik. Chem. B 32, 65 (1936).

    Google Scholar 

  29. Beckett, A. H., and A. F. Casy: Configurational studies in synthetic analgesics. J. Chem. Soc. Lond. 1955, 900.

    Google Scholar 

  30. —: Stereoisomerism and biologicalaction. J. of Pharmacy a. Pharmacol. 7, 433 (1955).

    CAS  Google Scholar 

  31. Bell, P. H., and R. O. Roblin: Studies in chemotherapy. VII. A theory of the relation of structure to activity of sulfanilamide type compounds. J. Amer. Chem. Soc. 64, 2905 (1942).

    CAS  Google Scholar 

  32. Bergel, F., and A. L. Morrison: Synthetic analgesics. Quart. Rev. Chem. Soc. Lond. 2, 349 (1948). *** DIRECT SUPPORT *** A0535004 00032

    CAS  Google Scholar 

  33. Bergel, F., and A. R. Todd: Aneurin. Part VIII. Some analogues of aneurin. J. Chem. Soc. Lond. 1937, 1504.

    Google Scholar 

  34. Berry, H., A. Cook and B. Wills: Bactericidal activities of soap-phenol mixtures. J. of Pharmacy a. Pharmacol. 8, 425 (1956).

    CAS  Google Scholar 

  35. Beyer, K. H., H. F. Russo, E. A. Parch, E. K. Tillson and G. Shnaer: Certain pharmacological properties of 4′-carboxyphenylmethanesulfonanilide (caronamide), including its effect on renal clearance of compounds other than penicillin. J. of Pharmacol. 91, 272 (1947).

    CAS  Google Scholar 

  36. Boyland, E.: The pharmacology of chloroethylamines. Biochem. Soc. Symposia 2, 61 (1948).

    CAS  Google Scholar 

  37. —, and A. M. Brues: The carcinogenic action of dibenzcarbazoles. Proc. Roy. Soc. Lond., Ser. B 122, 429 (1935).

    Google Scholar 

  38. Brink, F., and J. M. Posternak: Thermodynamic analysis of the relative effectiveness of narcotics. J. Cellul. a. Comp. Physiol. 32, 211 (1948).

    CAS  Google Scholar 

  39. Brodie, B. B.: Detoxication of drugs and other foreign compounds by liver microsomes. Science (Lancaster, Pa.) 121, 603 (1955).

    CAS  Google Scholar 

  40. —, L. Aronow and J. Axelrod: The fate of benzazoline (priscoline) in dog and man, and a method for its estimation in biological material. J of Pharmacol. 106, 200 (1952).

    CAS  Google Scholar 

  41. —, and J. Axelrod: Fate of acetanilide in man. J. of Pharmacol. 94, 29 (1948).

    CAS  Google Scholar 

  42. Brown, A. Crum and T. R. Fraser: On the connection between chemical constitution and physiological action: on the physiological action of the salts of ammonia of trimethylamine and of tetramethylammonium: of the salts of tropia and of the ammonium bases derived from it: and of tropic, atropic and isatropic acids and their salts. With further details of the physiological action of the salts of methyl-strychnium and of ethyl-strychnium. Proc. Rov. Soc. Edinburgh 6, 556 (1867).

    Google Scholar 

  43. Butler, T. C.: The metabolic fate of chloral hydrate. J. of Pharmacol. 92, 49 (1948).

    CAS  Google Scholar 

  44. — Theories of general anaesthesia. J. of Pharmacol. 98, 121 (1950).

    CAS  Google Scholar 

  45. Chadwick, L. E., and D. L. Hill: Inhibition of cholinesterase by diisopropyl fluorophosphate, physostigmine and hexaethyl tetraphosphate in the roach. J. of Neurophysiol. 10, 235 (1947).

    CAS  Google Scholar 

  46. Chenoweth, M.: Chelation as a mechanism of pharmacological action. Pharmacol. Rev. 8, 57 (1956).

    PubMed  CAS  Google Scholar 

  47. Close, W. U.: The conformation of the ephedrines. J. Organ. Chem. 15, 1131 (1950).

    CAS  Google Scholar 

  48. Clowes, G. H., A. K. Keltch and M. E. Krahl: The role of changes in extracellular and intracellular hydrogen-ion concentration in the action of local anaesthetic bases. J. of Pharmacol. 68, 312 (1940).

    CAS  Google Scholar 

  49. Collander, R.: The permeability of plant protoplasts to nonelectrolytes. Trans. Faraday Soc. 33, 985 (1937).

    CAS  Google Scholar 

  50. Cornforth, J. W., P. D’Arcy-Hart, G. A. Nicholls, R. J. Rees and J. A. Stock: Antituberculous effects of certain surface-active polyoxyethylene ethers. Brit. J. Pharmacol. 10, 73 (1955).

    PubMed  CAS  Google Scholar 

  51. Crowther, A. F., and A. A. Levi: Proguanil — the isolation of a metabolite with high antimalarial activity. Brit. J. Pharmacol. 8, 93 (1953).

    PubMed  CAS  Google Scholar 

  52. Cullen, S. C., and E. G. Gross: The anaesthetic properties of xenon in animals and human beings, with additional observations on krypton. Science (Lancaster, Pa.) 113, 580 (1951).

    CAS  Google Scholar 

  53. Dale, H. H., and W. Feldberg: Chemical transmitter of vagus effect to stomach. J. of Physiol. 81, 320 (1934).

    CAS  Google Scholar 

  54. — and M. Vogt: Release of acetylcholine at voluntary motor nerve endings. J. of Physiol. 86, 353 (1936).

    CAS  Google Scholar 

  55. Datta, S. P., and B. R. Rabin: The chelation of metal ions by dipeptides and related compounds. Biochem. et Biophysica Acta 19, 572 (1956).

    CAS  Google Scholar 

  56. Davson, H., and J. F. Danielli: The permeability of natural membranes. Cambridge: University Press 1952.

    Google Scholar 

  57. Dixon, M., and D. M. Needham: Biochemical research on chemical warfare agents. Nature (Lond.) 158 432 (1946).

    CAS  Google Scholar 

  58. Dobbie, H., and W. O. Kermack: Complex-formation between polypeptides and metals. Part II. The reaction between cupric ion and some dipeptides. Biochemic. J. 59, 246 (1955).

    CAS  Google Scholar 

  59. Eagle, H.: Effect of sulphydryl compounds on antispirochetal action of arsenic, bismuth and mercury compounds in vitro. J. of Pharmacol. 66, 436 (1939).

    CAS  Google Scholar 

  60. Edlbacher, S., H. Baur u. M. Becker: Enzymhemmung und Enzymblockierung. Z. Physiol Chem. 265, 61 (1940).

    CAS  Google Scholar 

  61. Ehrlich, P.: Letter to Carl Weigert (1898) (to be published in Ehrlich’s collected papers by the Wellcome Trust).

    Google Scholar 

  62. — On immunity with special reference to cell life. Proc. Roy. Soc. Lond., Ser. B 66, 424 (1900).

    CAS  Google Scholar 

  63. Ehrlich, P.: Über Hämolysine. Berl. klin. Wschr. 1900, 682; translated by C. Bolduan in “Studies in Immunity”, 2nd edit., p. 24. New York: Wiley 1910.

    Google Scholar 

  64. — Über den jetzigen Stand der Chemotherapie. Ber. dtsch. chem. Ges. 42, 17 (1909).

    CAS  Google Scholar 

  65. Elion, G., S. Bieber and G. Hitchings: The fate of 6-mercaptopurine in mice. Ann. New York Acad. Sci. 60, 297 (1954).

    CAS  Google Scholar 

  66. Emerson, G. A.: The antivitamin B6 activity of desoxypyridoxine in the rat. Federat. Proc. 6, 406 (1947).

    CAS  Google Scholar 

  67. Eusebi, A. J., and L. R. Cerecedo: In vivo and in vitro studies with oxythiamine and neopyrithiamine. Federat. Proc. 9, 169 (1950).

    Google Scholar 

  68. Eyles, D., and N. Coleman: Synergistic effect of sulfadiazine and daraprim against experimental toxoplasmosis in the mouse. Antibiotics a. Chemother. 3, 483 (1953).

    CAS  Google Scholar 

  69. Ferguson, J.: The use of chemical potentials as indices of toxicity. Proc. Roy. Soc. Lond., Ser. B 127, 387 (1939).

    CAS  Google Scholar 

  70. — Relations between thermodynamic indices of narcotic potency and the molecular structure of narcotics. Colloques internationaux du Centre Nationale de la Recherche Scientifique, Nr. 26, p. 25. Paris: Mécanisme de la narcose, 1951.

    Google Scholar 

  71. —, and H. Pirie: The toxicity of vapours to the grain weevil. Ann. Appl. Biol. 35, 532 (1948).

    CAS  Google Scholar 

  72. Fildes, P.: A rational approach to research in chemotherapy. Lancet 1940, i, 955.

    Google Scholar 

  73. — The mechanism of the anti-bacterial action of mercury. Brit. J. Exper. Path. 21, 67 (1940).

    CAS  Google Scholar 

  74. Gale, E. F.: The assimilation of amino-acids by bacteria. I. The passage of certain amino-acids across the cell wall and their concentration in the internal environment of streptococcus faecalis. J. Gen. Microbiol. 1, 53 (1947).

    PubMed  CAS  Google Scholar 

  75. Gale, E., and E. S. Taylor: The assimilation of amino-acids by bacteria. 2. The action of tyrocidin and some detergent substances in releasing amino-acids from the internal environment of Streptococcus faecalis. J. Gen. Microbiol. 1, 77 (1947).

    PubMed  CAS  Google Scholar 

  76. Goksøyr, J.: Reversal of the fungicidal effect of dithiocarbamyl compounds. Nature (Lond.) 175, 820 (1955).

    Google Scholar 

  77. Goldacre, R. J., and J. N. Phillips: The ionization of basic triphenylmethane dyes. J. Chem. Soc. Lond. 1949, 1724.

    Google Scholar 

  78. Gottlieb, R.: Pharmakologische Untersuchungen über die Stereoisomerie der Kokaine. Arch. exper. Path. u. Pharmakol. 97, 113 (1923).

    CAS  Google Scholar 

  79. Greathouse, G. A.: Private communication.

    Google Scholar 

  80. Gurd, F., and D. Goodman: Preparation and properties of serum and plasma proteins. XXXII. The interaction of human serum albumin with zinc ions. J. Amer. Chem. Soc. 74, 670 (1952).

    CAS  Google Scholar 

  81. Hahn, P. F., W. F. Bale, J. F. Ross, R. A. Hettig and G. H. Whipple: Radio-iron in plasma does not exchange with hemoglobin iron in red cells. Science (Lancaster, Pa.) 92, 131 (1940).

    CAS  Google Scholar 

  82. Hanby, W. E., G. S. Hartley, E. O. Powell and H. N. Rydon: The chemistry of 2-chloroalkylamines. Part II. Reactions of tertiary 2-chloroalkylamines in water. J. Chem. Soc. Lond. 1947, 519.

    Google Scholar 

  83. Hitchings, G. H.: Daraprim as an antagonist of folic and folinic acid. Trans. Roy. Soc. trop. Med. Lond. 46, 467 (1952).

    CAS  Google Scholar 

  84. Holmes, R., and E. L. Robins: The reversal by oximes of neuromuscular block produced by anticholinesterases. Brit. J. Pharmacol. 10, 490 (1955).

    PubMed  CAS  Google Scholar 

  85. Holton, P., and H. R. Ing: The specificity of the trimethylammonium group in acetylcholine. Brit. J. Pharmacol. 4, 190 (1949).

    PubMed  CAS  Google Scholar 

  86. Hotchkiss, R. D.: The nature of the bactericidal action of surface active agents. Ann. New York Acad. Sci. 46 (article 6), 479 (1946).

    CAS  Google Scholar 

  87. Ing, H. R.: The curariform action of onium salts. Physiologic. Rev. 16, 527 (1936).

    CAS  Google Scholar 

  88. — The structure-action relationship of the choline group. Science (Lancaster, Pa.) 109, 264 (1949).

    CAS  Google Scholar 

  89. —, P. Kordik and D. P. H. T. Williams: Studies of the structure-action relationship of the choline group. Brit. J. Pharmacol. 7, 103 (1952).

    PubMed  CAS  Google Scholar 

  90. Jacobs, M. H., H. N. Glassman and A. K. Parpart: Osmotic properties of erythrocyte; temperature coefficients of certain hemolytic processes. J. Cellul. a. Comp. Physiol. 7, 197 (1935).

    Google Scholar 

  91. Jacobson, W.: Personal communication 1956.

    Google Scholar 

  92. Jeener, R.: Influence of thiouracil incorporation in the ribonucleic acid moiety of tobacco-mosaic virus on its multiplication. Biochim. et Biophysica Acta 13, 148 (1954).

    CAS  Google Scholar 

  93. —, and J. Rosseels: Incorporation of 2-thiouracil-S35 in the ribonucleic acid (RNA) of tobacco-mosaic virus. Biochim. et Biophysica Acta 11, 438 (1953).

    CAS  Google Scholar 

  94. Josephson, E. S., D. J. Taylor, J. Greenberg and A. P. Ray: A metabolic intermediate of pamaquine from chickens. Proc. Soc. Exper. Biol. a. Med. 76, 700 (1951).

    CAS  Google Scholar 

  95. Kilby, B. A.: Anticholinesterases. The metabolic conversion of certain organic phosphorus compounds into anticholinesterases. Chem. a. Ind. 1954, 524.

    Google Scholar 

  96. Klotz, I. M., and W. Loh Ming: Mediation by metals of the binding of small molecules by proteins. J. Amer. Chem. Soc. 76, 805 (1954).

    CAS  Google Scholar 

  97. Krogh, A.: The active and passive exchanges of inorganic ions through the surfaces of living cells and through living membranes generally. Proc. Roy. Soc. Lond., Ser. B 133, 140 (1946).

    CAS  Google Scholar 

  98. Lawrence, J. H., W. F. Loomis, C. A. Tobias and F. H. Turpin: Preliminary observations on the narcotic effect of xenon with a review of values for solubilities of gases in water and oils. J. of Physiol. 105, 197 (1946).

    CAS  Google Scholar 

  99. Levaditi, C.: Mécanisme d’action de l’atoxyl dans la syphilis expérimentale du lapin. C. r. Soc. Biol. Paris 64, 911 (1908).

    Google Scholar 

  100. Loewi, O., and E. Navratil: Über den Mechanismus der Vaguswirkung von Physostigmin und Ergotamin. Pflügers Arch. 214, 689 (1926).

    CAS  Google Scholar 

  101. Lundegårdh, H.: Untersuchungen über die Anionenatmung. Biochem. Z. 290, 104 (1937).

    Google Scholar 

  102. Mackaness, G. B.: Artificial cellular immunity against tubercle bacilli. Amer. Rev. Tbc. 69, 690 (1954).

    CAS  Google Scholar 

  103. Matthews, R. E. F.: Effects of some purine analogues on tobacco mosaic virus. J. Gen. Microbiol. 10, 521 (1954).

    PubMed  CAS  Google Scholar 

  104. —, and J. D. Smith: Distribution of 8-azaguanine in the nucleic acids of bacillus cereus. Nature (Lond.) 177, 271 (1956).

    CAS  Google Scholar 

  105. Mitchell, J. H., H. E. Skipper and L. L. Bennet: Investigation of nucleic acids of viscera and tumor tissue from animals injected with radioactive 8-azaguanine. Cancer Res. 10, 647 (1950).

    CAS  Google Scholar 

  106. Mitchell, J. H., and J. Moyle: Biochemic. J. 1956 (Proceedings, in the press).

    Google Scholar 

  107. Mueller, J. F., and R. W. Vilter: Pyridoxine deficiency in human beings induced with desoxypyridoxine. J. Clin. Invest. 29, 193 (1950).

    PubMed  CAS  Google Scholar 

  108. Mullins, L. J.: Some physical mechanisms in narcosis. Chem. Rev. 54, 289 (1954).

    CAS  Google Scholar 

  109. Nachmanson, D., and E. Feld: Studies on cholinesterase. IV. The mechanism of diisopropyl fluorophosphate action in vivo. J. of Biol. Chem. 171, 715 (1947).

    Google Scholar 

  110. Newton, B. A.: Site of action of polymixin on Pseudomonas aeruginosa: antagonism by cations. J. Gen. Microbiol. 10, 491 (1954).

    PubMed  CAS  Google Scholar 

  111. Norton, S.: Quantitative determination of mast cell fragmentation by compound 48/80. Brit. J. Pharmacol. 9, 494 (1954).

    PubMed  CAS  Google Scholar 

  112. Osterhout, W. J. V.: Permeability in large plant cells and in models. Erg. Physiol. 35, 968 (1933).

    CAS  Google Scholar 

  113. — The absorption of electrolyses in large plant cells. Bot. Review 2, 283 (1936).

    CAS  Google Scholar 

  114. Overton, E.: Studien über die Narkose. Jena: Gustav Fischer 1901.

    Google Scholar 

  115. Peters, R. A., J. Bennet, G. Cameron, A. Carleton, M. Dixon, H. Findlay, J. Gaddum, F. Herrald, A. King, G. McElligott, L. Owen, L. Stocker, D. Williams and R. Thompson: British Anti-lewisite. Its use and therapeutic value in arsenical intoxications. Lancet 1947, ii, 497.

    Google Scholar 

  116. Peters, R. A., R. W. Wakelin, D. E. Rivett and L. C. Thomas: Fluoroacetate poisoning: comparison of synthetic fluorocitric acid with the enzymically synthesized fluorotricarboxylic acid. Nature (Lond.) 171, 1111 (1953).

    CAS  Google Scholar 

  117. Piper, C. S.: Investigations on copper deficiency in plants. J. Agricult. Sci. 32, 143 (1942).

    CAS  Google Scholar 

  118. Quastel, J. H., and W. R. Wooldridge: Experiments on bacteria in relation to mechanism of enzyme action. Biochemic. J. 21, 1224 (1927).

    CAS  Google Scholar 

  119. Raison, C. G., and O. D. Standen: The schistosomicidal activity of symmetrical diaminodiphenoxyalkanes. Brit. J. Pharmacol. 10, 191 (1955).

    PubMed  CAS  Google Scholar 

  120. Rideal, E. K.: Film reactions as a new approach to biologiy. Chem. a. Ind. 58, 830 (1939).

    Google Scholar 

  121. — Surface chemistry in relation to biology. Endeavour 4, 83 (1945).

    CAS  Google Scholar 

  122. Riegel, B., and L. T. Sherwood: The resolution of chloroquine. J. Amer. Chem. Soc. 71, 1129 (1949).

    CAS  Google Scholar 

  123. Rollo, I. M.: The mode of action of sulphonamides, proguanil and pyrimethamine on plasmodium gallinaceum. Brit. J. Pharmacol. 10, 208 (1955).

    PubMed  CAS  Google Scholar 

  124. Rowley, D., P. D. Cooper, P. W. Roberts and E. Lester Smith: The site of action of penicillin. I. The uptake of penicillin on bacteria. Biochemic. J. 46, 157 (1950).

    CAS  Google Scholar 

  125. —, J. Miller, S. Rowlands and E. Lester Smith: Investigations with radioactive penicillin. Nature (Lond.) 161, 1009 (1948).

    CAS  Google Scholar 

  126. Rubbo, S., A. Albert and M. Gibson: The influence of chemical constitution on antibacterial activity. Part V. The antibacterial action of 8-hydroxyquinoline (oxine). Brit. J. Exper. Path. 31, 425 (1950).

    CAS  Google Scholar 

  127. Russell, B., B. Green and L. Wand: Latent tetany caused by BAL: 2:3-dimercaptopropanol. Lancet 1948, ii, 169.

    Google Scholar 

  128. Salton, M. R.: The adsorption of cetyl trimethylammonium bromide by bacteria, its action in releasing cellular constituents and its bactericidal effects. J. Gen. Microbiol. 5, 391 (1951).

    PubMed  CAS  Google Scholar 

  129. Schultz, F.: Über die antineuritische Wirksamkeit von Vitamin B1-Homologen und-Analogen. Z. physiol. Chem. 265, 113 (1940).

    CAS  Google Scholar 

  130. Sidbury, J., J. Bynum and L. Fetz: Effect of chelating agent on urinary lead excretion. Comparison of oral and intravenous administration. Proc. Soc. Exper. Biol. a. Med. 82, 226 (1953).

    CAS  Google Scholar 

  131. Sijpestein, A. K., and G. J. M. van der Kerk: Investigations of organic fungicides. VI. Histidine as an antagonist of tetramethylthiuram disulphide (T.M.T.D.) and related compounds. Antonie van Leeuwenhoek 18, 83 (1952).

    Google Scholar 

  132. Simon, E. W.: Effect of pH on the biological activity of weak acids and bases. Nature (Lond.) 166, 343 (1950).

    CAS  Google Scholar 

  133. Smith, H.: The action of acids on cell division with reference to permeability to anions. Amer. J. Physiol. 72, 347 (1925).

    CAS  Google Scholar 

  134. Stearn, A. E., and E. W. Stearn: The chemical mechanism of bacterial behaviour. III. The problem of bacteriostasis. J. Bacter. 9, 491 (1924).

    CAS  Google Scholar 

  135. Stedman, E.: Molecular asymmetry and biological activity. Nature (Lond.) 159, 194 (1947).

    Google Scholar 

  136. —, and E. Stedman: Studies on the relationship between chemical constitution and physiological action. III. The inhibitory action of certain synthetic urethanes on the activity of liver esterase. Biochemic. J. 25, 1147 (1931).

    CAS  Google Scholar 

  137. Stewart, D. R., and M. H. Jacobs: The permeability of the egg of Arbacia punctulata to solutes and to water. J. Cellul. a. Comp. Physiol. 7, 333 (1936).

    CAS  Google Scholar 

  138. Straub, W., u. E. Triendl: Theorie der Abführwirkung der Folia Sennae und ihrer wirksamen Inhaltsstoffe. Arch. exper. Path. u. Pharmakol. 185, 1 (1937).

    CAS  Google Scholar 

  139. Tanford, C.: The effect of pH on the combination of serum albumin with metals. J. Amer. Chem. Soc. 74, 211 (1952).

    CAS  Google Scholar 

  140. Tatum, A., and G. A. Cooper: Experimental study of mapharsen (m-amino-p-hydroxyphenylarsine oxide) as antisyphilitic agent. J. of Pharmacol. 50, 198 (1934).

    CAS  Google Scholar 

  141. Tomcsik, J.: Effect of disinfectants and of surface active agents on bacterial protoplasts. Proc. Soc. Exper. Biol. a. Med. 89, 459 (1955).

    CAS  Google Scholar 

  142. Topley, B.: Insecticidal phosphorus compounds. Chem. a. Ind. 1950, 859.

    Google Scholar 

  143. Veldstra, H.: Synergism and potentiation. Pharmacol. Rev. 1956.

    Google Scholar 

  144. Vermast, P. G.: The theory of disinfection in the light of the Meyer-Overton lipoid theory. Biochem. Z. 125, 106 (1921).

    CAS  Google Scholar 

  145. Voegtlin, C.: The pharmacology of arsphenamine (salvarsan) and related arsenicals. Physiologic. Rev. 5, 63 (1925).

    CAS  Google Scholar 

  146. Wacker, A., H. Grisebach, A. Trebst, M. Ebert u. F. Weygand: Über den Wirkungsmechanismus der p-Aminosalicylsäure. Angew. Chem. 66, 712 (1954).

    CAS  Google Scholar 

  147. —, A. Trebst, D. Jacherts u. F. Weygand: Über den Einbau von 5-Bromouracil-[2-14C] in die Desoxyribonucleinsäure verschiedener Bakterien. Z. Naturforsch. 9b, 616 (1954).

    Google Scholar 

  148. Wettingfeld, R. F., J. Rowe and D. E. Eyles: Treatment of toxoplasmosis with pyrimethamine (Daraprim) and triple sulfonamide. Ann. Int. Med. 44, 557 (1956).

    PubMed  CAS  Google Scholar 

  149. Wilbrandt, W.: Permeabilitätsprobleme. Arch. exper. Path. u. Pharmakol. 212, 9 (1950).

    CAS  Google Scholar 

  150. Williams, R. T.: Detoxication mechanisms. London: Chapman & Hall 1947.

    Google Scholar 

  151. Wilson, A. N., and S. A. Harris: Synthesis and properties of neopyrithiamine salts. J. Amer. Chem. Soc. 71, 2231 (1949).

    CAS  Google Scholar 

  152. Wilson, I. B., and F. Bergmann: Acetylcholinesterase. VIII. Dissociation constants of the active groups. J. of Biol. Chem. 186, 683 (1950).

    CAS  Google Scholar 

  153. —, and E. K. Meislich: Reactivation of acetylcholinesterase inhibited by alkylphosphates. J. Amer. Chem. Soc. 75, 4628 (1953).

    CAS  Google Scholar 

  154. Wiselogle, F. Y.: A survey of antimalarial drugs. Ann Arbor, Mich.: J. W. Edwards 1, pp. 139 and 227. 1946.

    Google Scholar 

  155. Wohl, A., u. E. Glimm: Zur Kenntnis der Amylase (Diastase). Biochem. Z. 27, 349 (1910).

    Google Scholar 

  156. Woods, D. D.: Relation of p-aminobenzoic acid to mechanism of action of sulphanilamide. Brit. J. Exper. Path. 21, 74 (1940).

    CAS  Google Scholar 

  157. Woolley, D. W.: Pyrithiamine and neopyrithiamine. J. Amer. Chem. Soc. 72, 5763, (1950).

    CAS  Google Scholar 

  158. — A study of antimetabolites. New York: Wiley 1952.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medical Chemistry, Australian National University, Canberra, Australia

    Adrien Albert

Authors
  1. Adrien Albert
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1957 Springer-Verlag

About this paper

Cite this paper

Albert, A. (1957). The relationship between structure and biological activity: Some fundamental aspects. In: Ergebnisse der physiologie biologischen chemie und experimentellen pharmakologie. Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie, vol 49. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0113839

Download citation

  • DOI: https://doi.org/10.1007/BFb0113839

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-02135-3

  • Online ISBN: 978-3-540-36664-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation