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Renal System

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Handbook of Pediatric Autopsy Pathology

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Abstract

The kidney is composed of small reniculi, each with a papilla. The kidney grows by progressively adding nephrons to the surface; thus the capsular and subcapsular levels have much greater importance in the developing organ. The first rule in examining the kidneys at autopsy is not to strip the capsule but to clear away the perineal fat and inspect the surface. Note any of the reniculi that are different from the others, and do this before the kidneys are separated from the inferior vena cava. Abnormal and dysplastic reniculi are sometimes associated with an abnormal blood supply.

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References

  • Anton PA, Abramowsky CR. Adult polycystic renal disease presenting in infancy: a report emphasizing the bilateral involvement. J Urol 1982;128:1290,1291.

    PubMed  CAS  Google Scholar 

  • Ariel I, Wells TR, Landing BH, et al. Familial renal tubular dysgenesis: a disorder not isolated to proximal convoluted tubules. Pediatr Pathol Lab Med 1995;15:915–922.

    PubMed  CAS  Google Scholar 

  • Bernstein J, Risdon RA. Renal system. Part I-kidneys and urinary tract. In: Gilbert-Barness E, ed. Potter’s Pathology of the Fetus and Infant. St. Louis, Mosby Year Book, 1997.

    Google Scholar 

  • Bernstein J, Robbins TO, Kissane JM. The renal lesions of tuberous sclerosis. Semin Diagn Pathol 1986;3:97–105.

    PubMed  CAS  Google Scholar 

  • Bernstein JJ. Gomerulocystic kidney disease-nosological considerations. Pediatr Nephrol 1993;7:464.

    Article  PubMed  CAS  Google Scholar 

  • Bingham C, Bulman MP, Ellard S, et al. Mutations in the hepatocyte nuclear factor-1beta gene are associated with familiar hypoplastic glomerulocystic kidney disease. Am J Hum Genet 2001;68:219.

    Article  PubMed  CAS  Google Scholar 

  • Boyd T, Rosen S, Redline RW, Genest DR. Nondysplastic fetal renal hypoplasia associated with severe oligohydramnios: clinical, pathologic, and morphometric findings. Pediatr Pathol Lab Med 1995;15: 485.

    PubMed  CAS  Google Scholar 

  • Calvet JP, Grantham JJ. The genetics and physiology of polycystic kidney disease. Sem Nephrol 2001;21:107.

    Article  CAS  Google Scholar 

  • Ceccherini I, Litauania M, Cordone MS, et al. Autosomal dominant polycystic kidney disease: prenatal diagnosis by DNA analysis and sonography at 14 weeks. Prenat Diagn 1989;9:751.

    Article  PubMed  CAS  Google Scholar 

  • Clapp WL, Abrahamson DR. Development and gross anatomy of the kidney. In: Tisher CC, Brenner BM, eds: Renal Pathology with Clinical and Functional Correlations, 2nd ed, vol I. Philadelphia: JB Lippincott, 1992, p. 3.

    Google Scholar 

  • Dedeoglu IO, et al. Spectrum of glomerulocystic kidneys: a case report and review of the literature. Pediatr Pathol Lab Med 1996;16:941.

    PubMed  CAS  Google Scholar 

  • Gabow PA. Autosomal dominant polycystic kidney disease-more than a renal disease. Am J Kidney Dis 1990;16:403.

    PubMed  CAS  Google Scholar 

  • Gilbert-Barness E, Lacson A. Urinary tract and male genital system. In: Sternberg SS, ed. Diagnostic Surgical Pathology, 4th ed. Philadelphia: Lippincott, Williams and Wilkins, 2003.

    Google Scholar 

  • Husain AN, Pysher TJ, Dehner LP. The kidney and lower urinary tract. In: Stocker JT, Dehner LP, eds. Pediatric Pathology, 2nd ed. Philadelphia: Lippincott, Williams & Wilkins, 2001.

    Google Scholar 

  • Izquierdo L, Porteous M, Paramo PG, Connor JM. Evidence for genetic heterogeneity in hereditary hydronephrosis caused by pelvi-ureteric junction obstruction, with one locus assigned to chromosome 6p. Hum Genet 1992;89:557.

    Article  PubMed  CAS  Google Scholar 

  • Kaplan BS, Gordon I, Pincott J, et al. Familial hypoplastic glomerulo-cystic kidney disease: a definite entity with dominant inheritance. Am J Med Genet 34:569.

    Google Scholar 

  • Kaplan BS, Kaplan P, Rosenberg HK, et al. Polycystic kidney diseases in childhood. J Pediatr 1989;115:867.

    Article  PubMed  CAS  Google Scholar 

  • Kriegsmann J, Coerdt W, Kommoss F, Beetz R, et al. Renal tubular dysgenesis (RTD)-an important cause of the oligohydramnion-sequence. Report of 3 cases and review of the literature. Pathol Res Pract 2000; 196(12):861.

    PubMed  CAS  Google Scholar 

  • Landing BHM, Ang SM, Herta N, et al. Labeled lectin studies of renal atrophy of postnatal renal ischemia and end-stage kidney disease. Pediatr Pathol 1994;14:87.

    Article  PubMed  CAS  Google Scholar 

  • Lozanoff S, Johnston J, Ma W, Jourdan-Le Saux C. Immunohistochemical localization of Pax2 and associated protein in the developing kidney of mice with renal hypoplasia. J Histochem Cytochem 2001; 49(9):1081.

    PubMed  CAS  Google Scholar 

  • Matsell DG, Bennett T, Goodyer R, et al. The pathogenesis of multicystic dysplastic kidney disease: insights from the study of fetal kidneys. Lab Invest 1996;74:883.

    PubMed  CAS  Google Scholar 

  • McPherson E, Carey J, Kramer A, et al. Dominantly inherited renal adysplasia. Am J Med Genet 1987;26:863.

    Article  PubMed  CAS  Google Scholar 

  • Murugasu B, Cole BR, Hawkins EP, et al. Familial renal adysplasia. Am J Kidney Dis 1991;18:490.

    PubMed  CAS  Google Scholar 

  • Novelli G, Frontali M, Baldini D, et al. Prenatal diagnosis of adult polycystic kidney disease with DNA markers on chromosome 16 and the genetic heterogeneity problem. Prenat Diagn 1989;9:759.

    Article  PubMed  CAS  Google Scholar 

  • Onuchic LF, et al. PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a novel large protein containing multiple immunoglobulin-like plexin-transcription-factor domains and parallel beta-helix 1 repeats. Am J Hum Genet 2002;70:1305.

    Article  PubMed  CAS  Google Scholar 

  • Onuchic LF, Mrug M, Hou X, et al. Reginement of the autosomal recessive polycystic disease (PKHD1) interval and exclusion of an EF hand-containing gene a PKHD1 candidate gene. Am J Med Genet 2002;110:346.

    Article  PubMed  Google Scholar 

  • Park SH, Chi JEG. Oligomeganephronia associated with 4p deletion type chromosomal anomaly. Pediatr Pathol 1993;13:731.

    Article  PubMed  CAS  Google Scholar 

  • Rott HD, Lemcke B, Zenker M, et al. Cyst-like cerebral lesions in tuberous sclerosis. Am J Med Genet 2002;111(4):435.

    Article  PubMed  Google Scholar 

  • Sedman AB, Kershaw DB, Bunchman TE. Recognition and management of angiotensin converting enzyme inhibitor fetopathy. Pediatr Nephrol 1995;9:382.

    Article  PubMed  CAS  Google Scholar 

  • Zatyka M, de Silva NF, Clifford SC, et al. Identification of cyclin D1 and other novel targets for the von Hippel-Lindau tumor suppressor gene by expression array analysis and investigation of cyclin D1 genotype as a modifier in von Hippel-Lindau disease. Cancer Res 2002;62(13): 3803–3811.

    PubMed  CAS  Google Scholar 

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Editor information

Editors and Affiliations

  1. Pediatrics and Obstetrics and Gynecology, University of South Florida School of Medicine, Tampa, Florida

    Enid Gilbert-Barness AO, MBBS, MD, FRCPA, FRCPath, DSci(hc), MD(hc) (Professor of Pathology and Laboratory Medicine) (Professor of Pathology and Laboratory Medicine)

  2. Tampa General Hospital, Tampa, FL

    Enid Gilbert-Barness AO, MBBS, MD, FRCPA, FRCPath, DSci(hc), MD(hc) (Professor of Pathology and Laboratory Medicine) & Diane E. Debich-Spicer BS (Professor of Pathology and Laboratory Medicine) & 

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© 2005 Humana Press Inc., Totowa, NJ

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(2005). Renal System. In: Gilbert-Barness, E., Debich-Spicer, D.E. (eds) Handbook of Pediatric Autopsy Pathology. Humana Press. https://doi.org/10.1385/1-59259-673-8:301

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  • DOI: https://doi.org/10.1385/1-59259-673-8:301

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-224-7

  • Online ISBN: 978-1-59259-673-7

  • eBook Packages: MedicineMedicine (R0)

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