Abstract
Mrs. Showalter is a 60-year-old woman with well-controlled diabetes, which was diagnosed at age 45. She complains of cold, numb feet, noting pain primarily when water hits her feet after stepping into the shower or when the bedclothes brush against the feet after going to bed. She says that her feet often feel “dead” or “wooden” during the day. A physical examination reveals that she is wearing thick woolen socks, which she reports is necessary to keep her feet warm. Both feet appear normal, with good coloring, temperature, and pulses. Despite her complaints of “ numbness,” she is able to identify light touch throughout both feet. When approached with an open safety pin for pinprick testing, Mrs. Showalter reacts with dramatic withdrawal, complaining that the pin produces an intolerable, searing “fire” whenever it touches her feet. Her doctor orders Doppler studies and nerve conduction tests, both of which show relatively normal results. Because of the normal testing and lack of confirmatory examination evidence to support the claims of either coldness or numbness, Mrs. Showalter is advised to limit activities that may stress the foot and aggravate her pain. No other therapy is prescribed.
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References
Hasselström J, Liu-Palmgren J, Rasjö-Wrååk G. Prevalence of pain in general practice. Eur J Pain 2002; 6:375–385.
Gilron I, Bailey J, Weaver DF, Houlden RL. Patients’ attitudes and prior treatments in neuropathic pain: a pilot study. Pain Res Manag 2002; 7:199–203.
Boreau F, Doubrére, Luu. Study of verbal description in neuropathic pain. Pain 1990; 42:145–152.
Dworkin RH. An overview of neuropathic pain: syndromes, symptoms, signs, and several mechanisms. Clin J Pain 2002; 18:343–349.
Bennett M. The LANSS pain scale: the Leeds assessment of neuropathic symptoms and signs. Pain 2001; 92:147–157.
Young MJ, Boulton AJ, MacLeod AF, Williams DR, Sonksen PH. A multicentre study of the prevalence of diabetic peripheral neuropathy in the United Kingdom hospital clinic population. Diabetologia 1993; 36:150–154.
O’Hare JA, Abuaisha F, Geoghegan M. Prevalence and forms of neuropathic morbidity in 800 diabetics. Ir J Med Sci 1994; 163:132–135.
Scott FT, Leedhan-Green ME, Barrett-Muir WY, et al. A study of shingles and the development of postherpetic neuralgia in East London. J Med Virol 2003; 70(Suppl 1):S24–S30.
Chidiac C, Bruxelle J, Daures JP, et al. Characteristics of patients with herpes zoster on presentation to practitioners in France. Clin Infect Dis 2001; 33:62–69.
Merskey H, Bogduk N. Classification of chronic pain. Seattle, WA: IASP Press, 1994.
Galer BS, Bruehl S, Harden RN. Diagnostic clinical criteria for CRPS and painful diabetic neuropathy. Clin J Pain 1998; 14:48–54.
Galer BS, Butler S, Jensen M. Case reports and hypothesis: a neglect like syndrome may be responsible for the motor disturbance in reflex sympathetic dystrophy. J Pain Symptom Mange 1995; 10:385–392.
Sandroni P, Benrud-Larson LM, McClelland RL, Low PA. Complex regional pain syndrome type I: incidence and prevalence in Olmstead county, a population-based study. Pain 2003; 103:199–207.
Stute P, Soukup J, Menzel M, Sabatowski R, Grond S. Analysis and treatment of different types of neuropathic cancer pain. J Pain Symptom Manage 2003; 26:1123–1131.
Luciano CA, Pardo CA, McArthur JC. Recent developments in the HIV neuropathies. Curr Opin Neurol 2003; 16:403–409.
Schifitto G, McDermott MP, McArthur J, et al. Incidence of and risk factors for HIV-associated distal sensory polyneuropathy. Neurology 2002; 58:1764–1768.
Moore R, Wong WM, Keruly J, McArthur J. Incidence of neuropathy in HIVinfected patients on monotherapy versus those on combination therapy with didanosine, stavudine and hydroxyurea. AIDS 2000; 14:273–278.
Krishnan AM, Rayman G. New treatment for diabetic-neuropathy: symptomatic treatments. Curr Diabet Rep 2003; 3:459–467.
Fox A, Gentry C, Patel S, Kesingland A, Bevan S. Comparative activity of the anti-convulsants oxcarbazepine, carbamazepine, lamotrigine and gabapentin in a model of neuropathic pain in the rat and guinea-pig. Pain 2003; 105:355–362.
Backonja M, Glanzman RL. Gabapentin dosing for neuropathic pain: evidence from randomized, placebo-controlled clinical trials. Clin Ther 2003; 25:81–104.
Dallocchio C, Buffa C, Mazzarello P, Chiroli S. Gabapentin vs. amitriptyline in painful diabetic neuropathy: an open-label pilot study. J Pain Symptom Manage 2000; 20:280–285.
Berger A, Dukes E, McCarberg B, Liss M, Oster G. Change in opioid use after the initiation of gabapentin therapy in patients with postherpetic neuralgia. Clin Ther 2003; 25:2809–2821.
Haderer A, Gerner P, Kao G, Srinivasa V, Wang GK. Cutaneous analgesia after transdermal application of amitriptyline versus lidocaine in rats. Anesth Analg 2003; 96:1707–1710.
Marchand F, Alloui A, Pelissier T, et al. Evidence for an antihyperalgesic effect of venlafaxine in vincristine-induced neuropathy in rat. Brain Res 2003; 980:117–120.
Mattia C, Coluzzi F. Antidepressants in chronic neuropathic pain. Min Rev Med Chem 2003; 3:773–784.
Meier T, Wasner G, Faust M, et al. Efficacy of lidocaine patch 5% in the treatment of focal peripheral neuropathic pain syndromes: a randomized, double-blind, placebo-controlled study. Pain 2003; 106:151–158.
Biesbroeck R, Bril V, Hollander P, et al. A double-blind comparison of topical capsaicin and oral amitriptyline in painful diabetic neuropathy. Adv Ther 1995; 12:111–120.
Morley JS, Bridson J, Nash TP, Miles JB, White S, Makin MK. Low-dose methadone has an analgesic effect in neuropathic pain: a double-blind randomized controlled crossover trial. Palliat Med 2003; 17:576–587.
Watson CP, Moulin D, Watt-Watson J, Gordon A, Eisenhoffer J. Controlled-release oxycodone relieves neuropathic pain: a randomized controlled trial in painful diabetic neuropathy. Pain 2003; 105:71–78.
Wassilew SW, Wutzler P, Wutzler P. Oral brivudin in comparison with acyclovir for herpes zoster: a survey study on postherpetic neuralgia. Antiviral Res 2003; 59:57–60.
Bowsher D. The effects of pre-emptive treatment of postherpetic neuralgia with amitriptyline: a randomized, double-blind, placebo-controlled trial. J Pain Symptom Manage 1997; 13:327–331.
Pappagallo M, Haldey EJ. Pharmacological management of postherpetic neuralgia. CNS Drugs 2003; 17:771–780.
DeBeneditis G, Lorenzetti A. Topical aspirin/diethyl ether mixture versus indomethacin and diclofenac/diethyl ether mixture for acute herpetic neuralgia and postherpetic neuralgia: a double-blind, cross-over placebo controlled study. Pain 1996; 65:45–51.
Chung OY, Bruehl SP. Complex regional pain syndrome. Curr Treatment Options Neurol 2003; 5:499–511.
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(2005). Neuropathic Pain. In: Marcus, D.A. (eds) Chronic Pain. Current Clinical Practice. Humana Press. https://doi.org/10.1385/1-59259-882-X:111
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DOI: https://doi.org/10.1385/1-59259-882-X:111
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