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Molecular Therapeutic Approaches for Myocardial Protection

  • Chapter
Cardiovascular Genomics

Part of the book series: Contemporary Cardiology ((CONCARD))

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Abstract

Heart failure associated with coronary artery disease is a major cause of morbidity and mortality. Recent developments in the understanding of the molecular mechanisms of heart failure have led to the identification of novel therapeutic targets which, combined with the availability of efficient gene delivery vectors, offer the opportunity for the design of gene therapies for protection of the myocardium. Viral and cell-based therapies have been developed to treat polygenic and complex diseases such as myocardial ischemia, hypertension, atherosclerosis, and restenosis. In addition, cell-based therapies may have potential application in neovascularization and regeneration of ischemic and infarcted myocardium. The recent isolation of regeneration-competent endothelial precursor cells from adult bone marrow provides a novel opportunity for repair of the failing heart using autologous cell transplantation. In this chapter we will focus on the latest advances in the field of gene- and cell-based therapies for treatment of heart failure, and their clinical applications.

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Author information

Authors and Affiliations

  1. Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA

    Alok S. Pachori PhD & Victor J. Dzau MD

  2. Department of Physiology, Queen’s University College of Medicine, Kingston, Ontario, Canada

    Luis G. Melo PhD

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  1. Alok S. Pachori PhD
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  2. Luis G. Melo PhD
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  3. Victor J. Dzau MD
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Editor information

Editors and Affiliations

  1. Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL

    Mohan K. Rai ADA PhD

  2. Department of Physiology, School of Medical Sciences, University of Bristol, Bristol, UK

    Julian F. R. Paton PhD  & Sergey Kasparov MD, PhD  & 

  3. Department of Pharmacodynamics, University of Florida College of Pharmacy, Gainesville, FL

    Michael J. Katovich PhD

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© 2005 Humana Press Inc.

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Pachori, A.S., Melo, L.G., Dzau, V.J. (2005). Molecular Therapeutic Approaches for Myocardial Protection. In: Rai, M.K., Paton, J.F.R., Kasparov, S., Katovich, M.J. (eds) Cardiovascular Genomics. Contemporary Cardiology. Humana Press. https://doi.org/10.1385/1-59259-883-8:157

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  • DOI: https://doi.org/10.1385/1-59259-883-8:157

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-400-5

  • Online ISBN: 978-1-59259-883-0

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