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Gene Transfer and the Cardiovascular System

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Cardiovascular Genomics

Part of the book series: Contemporary Cardiology ((CONCARD))

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Abstract

The cardiovascular application of gene transfer and therapy has three overlapping goals. First, it can be seen as a molecular tool to probe pathways and mechanisms that are difficult to elucidate by other means. Second, it is widely used in preclinical studies and a variety of cardiovascular disease models to find the most efficient and safe clinical applications. Lastly, it is increasingly being used in clinical trial settings, for example to attenuate restenosis and vascular graft failure in coronary and peripheral vascular disease. We provide a critical overview of all three spheres of gene therapy-related strategies in cardiovascular disease research.

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Authors and Affiliations

  1. British Heart Foundation Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, Western Infirmary, University of Glasgow, Glasgow, UK

    William H. Miller PhD, Stuart A. Nicklin PhD, Andrew H. Baker PhD & Anna F. Dominiczak PhD

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  1. William H. Miller PhD
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  2. Stuart A. Nicklin PhD
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  3. Andrew H. Baker PhD
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  4. Anna F. Dominiczak PhD
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Editor information

Editors and Affiliations

  1. Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL

    Mohan K. Rai ADA PhD

  2. Department of Physiology, School of Medical Sciences, University of Bristol, Bristol, UK

    Julian F. R. Paton PhD  & Sergey Kasparov MD, PhD  & 

  3. Department of Pharmacodynamics, University of Florida College of Pharmacy, Gainesville, FL

    Michael J. Katovich PhD

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Miller, W.H., Nicklin, S.A., Baker, A.H., Dominiczak, A.F. (2005). Gene Transfer and the Cardiovascular System. In: Rai, M.K., Paton, J.F.R., Kasparov, S., Katovich, M.J. (eds) Cardiovascular Genomics. Contemporary Cardiology. Humana Press. https://doi.org/10.1385/1-59259-883-8:175

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  • DOI: https://doi.org/10.1385/1-59259-883-8:175

  • Publisher Name: Humana Press

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