1. Preface

   • Andrzej S. Tarnawski
   • Tetsuo Arakawa

   Announcement Pages: S1 - S2

2. 15th Anniversary of Rebamipide: Looking Ahead to the New Mechanisms and New Applications

   • Tetsuo Arakawa
   • Kazuhide Higuchi
   • Andrzej S. Tarnawski

   OriginalPaper Pages: S3 - S11

3. Roles of Platelets and Proteinase-Activated Receptors in Gastric Ulcer Healing

   • Rafael Perini
   • John L. Wallace

   OriginalPaper Pages: S12 - S15

4. The Role of Cyclooxygenase in Gastric Mucosal Protection

   • Katya Gudis
   • Choitsu Sakamoto

   OriginalPaper Pages: S16 - S23

5. Cellular and Molecular Mechanisms of Gastrointestinal Ulcer Healing

   • Andrzej S. Tarnawski

   OriginalPaper Pages: S24 - S33

6. Cellular and Molecular Mechanisms of the Epithelial Repair in IBD

   • Ryuichi Okamoto
   • Mamoru Watanabe

   OriginalPaper Pages: S34 - S38

7. Antiulcer Drugs and Gastric Cancer

   • Helge L. Waldum
   • Bjørn Gustafsson
   • Gunnar Qvigstad

   OriginalPaper Pages: S39 - S44

8. Global Analysis of Gene Expression in Gastric Ischemia-Reperfusion: A Future Therapeutic Direction for Mucosal Protective Drugs

   • Yuji Naito
   • Katsura Mizushima
   • Toshikazu Yoshikawa

   OriginalPaper Pages: S45 - S55

9. Rebamipide Decreases the Susceptibility of Gastric Mucosa to Acid-Induced Injury in Rats by Inhibiting Neutrophil Activation

   • Naoaki Harada
   • Kenji Okajima
   • Wenge Liu

   OriginalPaper Pages: S56 - S62

10. Rebamipide Reduces Delay in Gastric Ulcer Healing in Cyclooxygenase-2-Deficient Mice

    • Toshio Watanabe
    • Kazuhide Higuchi
    • Tetsuo Arakawa

    OriginalPaper Pages: S63 - S69

11. Gastroprotective Agent Rebamipide Induces Cyclooxygenase-2 (COX-2) in Gastric Epithelial Cells

    • Hiroaki Murata
    • Yuki Yabe
    • Norio Hayashi

    OriginalPaper Pages: S70 - S75

12. Rebamipide Significantly Inhibits Indomethacin-Induced Mitochondrial Damage, Lipid Peroxidation, and Apoptosis in Gastric Epithelial RGM-1 Cells

    • Yumiko Nagano
    • Hirofumi Matsui
    • Yukio Nakamura

    OriginalPaper Pages: S76 - S83

13. Rebamipide Reduces Indomethacin-Induced Gastric Injury in Mice via Down-Regulation of ICAM-1 Expression

    • Tetsuro Hiratsuka
    • Seiji Futagami
    • Choitsu Sakamoto

    OriginalPaper Pages: S84 - S89

14. Rebamipide Reduces Recurrence of Experimental Gastric Ulcers: Role of Free Radicals and Neutrophils

    • Kazushi Sakurai
    • Toshihiro Osaka
    • Katsuya Yamasaki

    OriginalPaper Pages: S90 - S96

15. Prevention by Rebamipide of Acute Reflux Esophagitis in Rats

    • Kazuhiro Katada
    • Norimasa Yoshida
    • Toshikazu Yoshikawa

    OriginalPaper Pages: S97 - S103

16. Rebamipide, a Gastroprotective Drug, Inhibits Indomethacin-Induced Apoptosis in Cultured Rat Gastric Mucosal Cells: Association with the Inhibition of Growth Arrest and DNA Damage-Induced 45α Expression

    • Yuji Naito
    • Hirokazu Kajikawa
    • Toshikazu Yoshikawa

    OriginalPaper Pages: S104 - S112

17. Direct Autoradiographic Evidence that Rebamipide Interacts with Neutrophils in Dextran Sulfate Sodium Induced Colitis in Rats

    • Masahiko Nakamura
    • Tetsufumi Takahashi
    • Kanji Tsuchimoto

    OriginalPaper Pages: S113 - S118

18. Rebamipide Enemas–New Effective Treatment for Patients with Corticosteroid Dependent or Resistant Ulcerative Colitis

    • Mitsuki Miyata
    • Kunio Kasugai
    • Takeshi Mori

    OriginalPaper Pages: S119 - S123

19. Rebamipide Enema is Effective for Treatment of Experimental Dextran Sulfate Sodium Induced Colitis in Rats

    • Takako Nakashima
    • Takashi Maeda
    • Toyoki Mori

    OriginalPaper Pages: S124 - S131