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Design and Fabrication of Biological Wires

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Cardiac Tissue Engineering

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1181))

Abstract

Cardiac tissue engineering using human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) has facilitated the creation of in vitro diagnostic platforms to study novel small molecules and cardiac disease at the tissue level. Yet, due to the immaturity of hPSC-CMs, there is a low fidelity between tissue-engineered cardiac tissues and adult cardiac tissues. To address this challenge, we have developed a platform that combines both physical and electrical cues to guide hPSC-CMs towards a more mature state in vitro.

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Author information

Authors and Affiliations

  1. Institute of Biomaterials and Biomedical Engineering, Department of Chemical Engineering and Applied Chemistry, University of Toronto, 164 College Street, Room 407, Toronto, ON, Canada, M5S 3G9

    Jason W. Miklas, Sara S. Nunes, Boyang Zhang & Milica Radisic

  2. Toronto General Research Institute, University Health Network, Toronto, ON, Canada, M5G 1L7

    Sara S. Nunes & Milica Radisic

  3. Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON, Canada, M5G 1A1

    Boyang Zhang

Authors
  1. Jason W. Miklas
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  2. Sara S. Nunes
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  3. Boyang Zhang
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  4. Milica Radisic
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Corresponding author

Correspondence to Milica Radisic .

Editor information

Editors and Affiliations

  1. Department Chemical Engineering&Applied Chemistry, University of Toronto, Toronto, Ontario, Canada

    Milica Radisic

  2. Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, USA

    Lauren D. Black III

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Miklas, J.W., Nunes, S.S., Zhang, B., Radisic, M. (2014). Design and Fabrication of Biological Wires. In: Radisic, M., Black III, L. (eds) Cardiac Tissue Engineering. Methods in Molecular Biology, vol 1181. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1047-2_14

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  • DOI: https://doi.org/10.1007/978-1-4939-1047-2_14

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-1046-5

  • Online ISBN: 978-1-4939-1047-2

  • eBook Packages: Springer Protocols

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