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Penetratin Story: An Overview

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Cell-Penetrating Peptides

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1324))

Abstract

Cell-penetrating peptides are short, often hydrophilic peptides that get access to the intracellular milieu. They have aroused great interest both in academic and applied research. First, cellular internalization of CPPs often involves the crossing of a biological membrane (plasma or vesicular), thus challenging the view of the non-permeability of these structures to large hydrophilic molecules. Secondly, CPPs can drive the internalization of hydrophilic cargoes into cells, a rate-limiting step in the development of many therapeutic substances. Interestingly, the two most used CPPs, TAT and penetratin peptides, are derived from natural proteins, HIV Tat and Antennapedia homeoprotein, respectively. The identification of the penetratin peptide, summarized in this review, is intimately linked to the study of its parental natural protein.

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Authors and Affiliations

  1. Center for Interdisciplinary Research in Biology (CIRB), Labex Memolife, PSL Research University, College de France, Paris, France

    Edmond Dupont, Alain Prochiantz & Alain Joliot

  2. CNRS, UMR 7241, Paris, France

    Edmond Dupont & Alain Prochiantz

  3. INSERM U1050, Paris, France

    Edmond Dupont, Alain Prochiantz & Alain Joliot

  4. Homeoproteins and Plasticity, CIRB, CNRS UMR 7241/INSERM U1050, Labex Memolife, PSL Research University, Collège de France, 11 Place Marcelin Berthelot, 75231, Paris Cedex 05, France

    Alain Joliot

Authors
  1. Edmond Dupont
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  2. Alain Prochiantz
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  3. Alain Joliot
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Correspondence to Alain Joliot .

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Editors and Affiliations

  1. Department of Neurochemistry, Stockholm University, Stockholm, Sweden

    Ülo Langel

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Dupont, E., Prochiantz, A., Joliot, A. (2015). Penetratin Story: An Overview. In: Langel, Ü. (eds) Cell-Penetrating Peptides. Methods in Molecular Biology, vol 1324. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2806-4_2

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  • DOI: https://doi.org/10.1007/978-1-4939-2806-4_2

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-2805-7

  • Online ISBN: 978-1-4939-2806-4

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