Abstract
Oral vaccines are easier to administer than injectable vaccines. To induce an adequate immune response using vaccines, antigenic proteins are usually combined with adjuvant materials. This chapter presents methodologies for the design of oral vaccines using molecular display technology. In molecular display technology, antigenic proteins are displayed on a microbial cell surface with adjuvant ability. This technology would provide a quite convenient process to produce oral vaccines when the DNA sequence of an efficient antigenic protein is available. As an example, oral vaccines against candidiasis were introduced using two different molecular display systems with Saccharomyces cerevisiae and Lactobacillus casei.
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Acknowledgements
We thank Miki Karasaki for the preparation of figures. This chapter described the work supported by the regional innovation creation R&D programs of the Ministry of Economy, Trade and Industry, Japan (22R5005).
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Shibasaki, S., Ueda, M. (2016). Oral Vaccine Development by Molecular Display Methods Using Microbial Cells. In: Thomas, S. (eds) Vaccine Design. Methods in Molecular Biology, vol 1404. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-3389-1_32
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DOI: https://doi.org/10.1007/978-1-4939-3389-1_32
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