Abstract
The assembly line is one of the key features of industrial production on the macroscopic scale, allowing programmability and sequential addition of parts to a final product. In this chapter, we use DNA to extend this notion to the nanoscale by the judicious combination of three DNA-based components: a DNA origami tile that provides a framework and track for the assembly process, three two-state DNA cassettes that can be programmed to donate cargo and are attached to the tile, and a DNA walker that can move on the track to collect cargo.
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Acknowledgements
H.G. thank members of the Seeman laboratory for helpful discussions. H.G. was supported by China “Thousand Youth Talents” (KHH1340004) and Fudan University startup (JJH1340110) grants.
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Zhang, X., Ding, X., Zou, J., Gu, H. (2017). A Proximity-Based Programmable DNA Nanoscale Assembly Line. In: Ke, Y., Wang, P. (eds) 3D DNA Nanostructure. Methods in Molecular Biology, vol 1500. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6454-3_18
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DOI: https://doi.org/10.1007/978-1-4939-6454-3_18
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