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Introduction: T Cell Trafficking in Inflammation and Immunity

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T-Cell Trafficking

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1591))

Abstract

T cell migration across vascular endothelium is essential for T cell responses, as through the expression of specific tissue-homing receptors, these cells then access peripheral tissues, with the goal of eliminating invading pathogens and/or tumor cells. However, aberrant trafficking of T cells to peripheral tissues contributes to the development of most chronic inflammatory diseases. Very little is known about the mechanisms by which T cell trafficking is regulated during inflammation, and it is thus difficult to target this aspect of pathology for the development of new therapies. It is therefore important to understand the pathways involved in regulating the recruitment of immune cells.

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Authors and Affiliations

  1. Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK

    Myriam Chimen Ph.D.

  2. Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, West Midlands, B15 2TT, UK

    Bonita H. R. Apta Ph.D.

  3. Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK

    Helen M. Mcgettrick Ph.D.

Authors
  1. Myriam Chimen Ph.D.
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  2. Bonita H. R. Apta Ph.D.
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  3. Helen M. Mcgettrick Ph.D.
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Corresponding author

Correspondence to Helen M. Mcgettrick Ph.D. .

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Editors and Affiliations

  1. Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, United Kingdom

    George Edward Rainger

  2. Institute of Inflammation and Ageing, College of Medicine and Dental Sciences, University of Birmingham, Birmingham, United Kingdom

    Helen M. Mcgettrick

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Chimen, M., Apta, B.H.R., Mcgettrick, H.M. (2017). Introduction: T Cell Trafficking in Inflammation and Immunity. In: Rainger, G., Mcgettrick, H. (eds) T-Cell Trafficking. Methods in Molecular Biology, vol 1591. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6931-9_6

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  • DOI: https://doi.org/10.1007/978-1-4939-6931-9_6

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