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Metabolomics in Immunology Research

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Clinical Metabolomics

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1730))

Abstract

There is a growing appreciation that metabolic processes and individual metabolites can shape the function of immune cells and thereby play important roles in the outcome of immune responses. In this respect, the use of MS- and NMR spectroscopy-based platforms to characterize and quantify metabolites in biological samples has recently yielded important novel insights into how our immune system functions and has contributed to the identification of biomarkers for immune-mediated diseases. Here, these recent immunological studies in which metabolomics has been used and made significant contributions to these fields will be discussed. In particular the role of metabolomics to the rapidly advancing field of cellular immunometabolism will be highlighted as well as the future prospects of such metabolomic tools in immunology.

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Acknowledgments

This work was in part funded by an LUMC and Marie Curie fellowship (#631585). I declare to have no competing interests.

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  1. Department of Parasitology, Leiden University Medical Center (LUMC), Leiden, The Netherlands

    Bart Everts

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  1. Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands

    Martin Giera

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Everts, B. (2018). Metabolomics in Immunology Research. In: Giera, M. (eds) Clinical Metabolomics. Methods in Molecular Biology, vol 1730. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7592-1_2

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  • DOI: https://doi.org/10.1007/978-1-4939-7592-1_2

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