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Pregnancy and Lactation: A Window of Opportunity to Improve Individual Health

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Investigations of Early Nutrition Effects on Long-Term Health

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1735))

Abstract

Human and animal studies indicate that obesity during pregnancy adversely impacts both maternal health and offspring phenotype predisposing them to chronic diseases later in life including obesity, dyslipidemia, type 2 diabetes mellitus, and hypertension. Effective interventions during human pregnancy and/or lactation are needed to improve both maternal and offspring health. This review addresses the relationship between adverse perinatal insults and its negative impact on offspring development and presents some maternal intervention studies such as diet modification, probiotic consumption, or maternal exercise, to prevent or alleviate the negative outcomes in both the mother and her child.

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References

  1. Tain YL, Hsu CN (2017) Developmental origins of chronic kidney disease: should we focus on early life? Int J Mol Sci 18(2):E381

    Article  PubMed  Google Scholar 

  2. Dickinson H, Moss TJ, Gatford KL, Moritz KM, Akison L, Fullston T et al (2016) A review of fundamental principles for animal models of DOHaD research: an Australian perspective. J Dev Orig Health Dis 7:449–472

    Article  CAS  PubMed  Google Scholar 

  3. Briffa JF, O’Dowd R, Moritz KM, Romano T, Jedwab LR, McAinch AJ et al (2017) Uteroplacental insufficiency reduces rat plasma leptin concentrations and alters placental leptin transporters: ameliorated with enhanced milk intake and nutrition. J Physiol 595:3389–3407

    Article  CAS  PubMed  Google Scholar 

  4. Burton GJ, Fowden AL, Thornburg KL (2016) Placental origins of chronic disease. Physiol Rev 96:1509–1565

    Article  PubMed  PubMed Central  Google Scholar 

  5. Cuffe JS, Turton EL, Akison LK, Bielefeldt-Ohmann H, Moritz KM (2017) Prenatal corticosterone exposure programs sex-specific adrenal adaptations in mouse offspring. J Endocrinol 232:37–48

    Article  CAS  PubMed  Google Scholar 

  6. Savoy C, Ferro MA, Schmidt LA, Saigal S, Van Lieshout RJ (2016) Prenatal betamethasone exposure and psychopathology risk in extremely low birth weight survivors in the third and fourth decades of life. Psychoneuroendocrinology 74:278–285

    Article  CAS  PubMed  Google Scholar 

  7. Arabin B, Baschat AA (2017) Pregnancy: an underutilized window of opportunity to improve long-term maternal and infant health-an appeal for continuous family care and interdisciplinary communication. Front Pediatr 5:69

    Article  PubMed  PubMed Central  Google Scholar 

  8. Pankey CL, Walton MW, Odhiambo JF, Smith AM, Ghnenis AB, Nathanielsz PW et al (2017) Intergenerational impact of maternal overnutrition and obesity throughout pregnancy in sheep on metabolic syndrome in grandsons and granddaughters. Domest Anim Endocrinol 60:67–74

    Article  CAS  PubMed  Google Scholar 

  9. Rodriguez-Rodriguez P, Lopez de Pablo AL, Garcia-Prieto CF, Somoza B, Quintana-Villamandos B, Gomez de Diego JJ et al (2017) Long term effects of fetal undernutrition on rat heart. Role of hypertension and oxidative stress. PLoS One 12(2):e0171544

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  10. Entringer S, Buss C, Wadhwa PD (2010) Prenatal stress and developmental programming of human health and disease risk: concepts and integration of empirical findings. Curr Opin Endocrinol Diabetes Obes 17:507–516

    Article  PubMed  PubMed Central  Google Scholar 

  11. Lesage J, Del-Favero F, Leonhardt M, Louvart H, Maccari S, Vieau D (2004) Prenatal stress induces intrauterine growth restriction and programmes glucose intolerance and feeding behaviour disturbances in the aged rat. J Endocrinol 181:291–296

    Article  CAS  PubMed  Google Scholar 

  12. Koren O, Goodrich JK, Cullender TC, Spor A, Laitinen K, Backhed HK et al (2012) Host remodeling of the gut microbiome and metabolic changes during pregnancy. Cell 150:470–480

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Ma J, Prince AL, Bader D, Hu M, Ganu R, Baquero K et al (2014) High-fat maternal diet during pregnancy persistently alters the offspring microbiome in a primate model. Nat Commun 5:3889

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Wesolowski SR, Kasmi KC, Jonscher KR, Friedman JE (2017) Developmental origins of NAFLD: a womb with a clue. Nat Rev Gastroenterol Hepatol 14:81–96

    Article  CAS  PubMed  Google Scholar 

  15. Zambrano E, Nathanielsz PW (2013) Mechanisms by which maternal obesity programs offspring for obesity: evidence from animal studies. Nutr Rev 71(Suppl 1):S42–S54

    Article  PubMed  Google Scholar 

  16. Rabadan-Diehl C, Nathanielsz P (2013) From mice to men: research models of developmental programming. J Dev Orig Health Dis 4:3–9

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Gardner DS, Tingey K, Van Bon BW, Ozanne SE, Wilson V, Dandrea J et al (2005) Programming of glucose-insulin metabolism in adult sheep after maternal undernutrition. Am J Physiol Regul Integr Comp Physiol 289:R947–R954

    Article  CAS  PubMed  Google Scholar 

  18. Long NM, George LA, Uthlaut AB, Smith DT, Nijland MJ, Nathanielsz PW et al (2010) Maternal obesity and increased nutrient intake before and during gestation in the ewe results in altered growth, adiposity, and glucose tolerance in adult offspring. J Anim Sci 88:3546–3553

    Article  CAS  PubMed  Google Scholar 

  19. Forhead AJ, Fowden AL (2009) The hungry fetus? Role of leptin as a nutritional signal before birth. J Physiol 587:1145–1152

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Nakae J, Kido Y, Accili D (2001) Distinct and overlapping functions of insulin and IGF-I receptors. Endocr Rev 22:818–835

    Article  CAS  PubMed  Google Scholar 

  21. Bispham J, Gopalakrishnan GS, Dandrea J, Wilson V, Budge H, Keisler DH et al (2003) Maternal endocrine adaptation throughout pregnancy to nutritional manipulation: consequences for maternal plasma leptin and cortisol and the programming of fetal adipose tissue development. Endocrinology 144:3575–3585

    Article  CAS  PubMed  Google Scholar 

  22. Bondesson M, Hao R, Lin CY, Williams C, Gustafsson JA (2015) Estrogen receptor signaling during vertebrate development. Biochim Biophys Acta 1849:142–151

    Article  CAS  PubMed  Google Scholar 

  23. Hiort O (2013) The differential role of androgens in early human sex development. BMC Med 11:152

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Zambrano E, Reyes-Castro LA, Nathanielsz PW (2015) Aging, glucocorticoids and developmental programming. Age 37:9774

    Article  CAS  PubMed  Google Scholar 

  25. Larque E, Pagan A, Prieto MT, Blanco JE, Gil-Sanchez A, Zornoza-Moreno M et al (2014) Placental fatty acid transfer: a key factor in fetal growth. Ann Nutr Metab 64:247–253

    Article  CAS  PubMed  Google Scholar 

  26. Sutton EF, Gilmore LA, Dunger DB, Heijmans BT, Hivert MF, Ling C et al (2016) Developmental programming: state-of-the-science and future directions-summary from a Pennington biomedical symposium. Obesity 24:1018–1026

    Article  PubMed  PubMed Central  Google Scholar 

  27. Luo ZC, Fraser WD, Julien P, Deal CL, Audibert F, Smith GN et al (2006) Tracing the origins of “fetal origins” of adult diseases: programming by oxidative stress? Med Hypotheses 66:38–44

    Article  CAS  PubMed  Google Scholar 

  28. Vega CC, Reyes-Castro LA, Rodriguez-Gonzalez GL, Bautista CJ, Vazquez-Martinez M, Larrea F et al (2016) Resveratrol partially prevents oxidative stress and metabolic dysfunction in pregnant rats fed a low protein diet and their offspring. J Physiol 594:1483–1499

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Lane RH (2014) Fetal programming, epigenetics, and adult onset disease. Clin Perinatol 41:815–831

    Article  PubMed  Google Scholar 

  30. Perera F, Herbstman J (2011) Prenatal environmental exposures, epigenetics, and disease. Reprod Toxicol 31:363–373

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Bhutta ZA, Ahmed T, Black RE, Cousens S, Dewey K, Giugliani E et al (2008) What works? Interventions for maternal and child undernutrition and survival. Lancet 371(9610):417–440

    Article  PubMed  Google Scholar 

  32. Black RE, Allen LH, Bhutta ZA, Caulfield LE, de Onis M, Ezzati M et al (2008) Maternal and child undernutrition: global and regional exposures and health consequences. Lancet 371(9608):243–260

    Article  PubMed  Google Scholar 

  33. Bryce J, Coitinho D, Darnton-Hill I, Pelletier D, Pinstrup-Andersen P, Maternal and Child Undernutrition Study Group (2008) Maternal and child undernutrition: effective action at national level. Lancet 371(9611):510–526

    Article  PubMed  Google Scholar 

  34. Morris SS, Cogill B, Uauy R, Maternal and Child Undernutrition Study Group (2008) Effective international action against undernutrition: why has it proven so difficult and what can be done to accelerate progress? Lancet 371(9612):608–621

    Article  PubMed  Google Scholar 

  35. Victora CG, Adair L, Fall C, Hallal PC, Martorell R, Richter L et al (2008) Maternal and child undernutrition: consequences for adult health and human capital. Lancet 371(9609):340–357

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Nathanielsz PW, Ford SP, Long NM, Vega CC, Reyes-Castro LA, Zambrano E (2013) Interventions to prevent adverse fetal programming due to maternal obesity during pregnancy. Nutr Rev 71(Suppl 1):S78–S87

    Article  PubMed  PubMed Central  Google Scholar 

  37. Zambrano E, Ibanez C, Martinez-Samayoa PM, Lomas-Soria C, Durand-Carbajal M, Rodriguez-Gonzalez GL (2016) Maternal obesity: lifelong metabolic outcomes for offspring from poor developmental trajectories during the perinatal period. Arch Med Res 47:1–12

    Article  PubMed  Google Scholar 

  38. Poston L (2012) Maternal obesity, gestational weight gain and diet as determinants of offspring long term health. Best Pract Res Clin Endocrinol Metab 26:627–639

    Article  PubMed  Google Scholar 

  39. Rodriguez JS, Rodriguez-Gonzalez GL, Reyes-Castro LA, Ibanez C, Ramirez A, Chavira R et al (2012) Maternal obesity in the rat programs male offspring exploratory, learning and motivation behavior: prevention by dietary intervention pre-gestation or in gestation. Int J Dev Neurosci 30:75–81

    Article  CAS  PubMed  Google Scholar 

  40. Mathiesen ER, Vaz JA (2008) Insulin treatment in diabetic pregnancy. Diabetes Metab Res Rev 24(Suppl 2):S3–20

    Article  CAS  PubMed  Google Scholar 

  41. Carruth BR, Skinner JD (1991) Practitioners beware: regional differences in beliefs about nutrition during pregnancy. J Am Diet Assoc 91(4):435–440

    CAS  PubMed  Google Scholar 

  42. Clark M, Ogden J (1999) The impact of pregnancy on eating behaviour and aspects of weight concern. Int J Obes Relat Metab Disord 23:18–24

    Article  CAS  PubMed  Google Scholar 

  43. National Research Council, Institute of Medicine, Youth, and Families Board on Children, Food and Nutrition Board, Committee to Reexamine IOM Pregnancy Weight Guidelines (2009) In: Yaktine AL, Rasmussen KM (eds) Weight gain during pregnancy: reexamining the guidelines. National Academies Press, Washington DC. ISBN-10: 0309131138

    Google Scholar 

  44. Siega-Riz AM, Viswanathan M, Moos MK, Deierlein A, Mumford S, Knaack J et al (2009) A systematic review of outcomes of maternal weight gain according to the Institute of Medicine recommendations: birthweight, fetal growth, and postpartum weight retention. Am J Obstet Gynecol 201(339):e331–e314

    Google Scholar 

  45. Shah BR, Retnakaran R, Booth GL (2008) Increased risk of cardiovascular disease in young women following gestational diabetes mellitus. Diabetes Care 31:1668–1669

    Article  PubMed  PubMed Central  Google Scholar 

  46. Hedderson MM, Gunderson EP, Ferrara A (2010) Gestational weight gain and risk of gestational diabetes mellitus. Obstet Gynecol 115:597–604

    Article  PubMed  PubMed Central  Google Scholar 

  47. Rooney BL, Schauberger CW, Mathiason MA (2005) Impact of perinatal weight change on long-term obesity and obesity-related illnesses. Obstet Gynecol 106:1349–1356

    Article  PubMed  Google Scholar 

  48. Schack-Nielsen L, Michaelsen KF, Gamborg M, Mortensen EL, Sorensen TI (2010) Gestational weight gain in relation to offspring body mass index and obesity from infancy through adulthood. Int J Obes 34:67–74

    Article  CAS  Google Scholar 

  49. Thangaratinam S, Rogozinska E, Jolly K, Glinkowski S, Duda W, Borowiack E et al (2012) Interventions to reduce or prevent obesity in pregnant women: a systematic review. Health Technol Assess 16(31):iii–iv, 1–191

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  50. Thangaratinam S, Rogozinska E, Jolly K, Glinkowski S, Roseboom T, Tomlinson JW et al (2012) Effects of interventions in pregnancy on maternal weight and obstetric outcomes: meta-analysis of randomised evidence. BMJ 344:e2088

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Skouteris H, Hartley-Clark L, McCabe M, Milgrom J, Kent B, Herring SJ et al (2010) Preventing excessive gestational weight gain: a systematic review of interventions. Obes Rev 11:757–768

    Google Scholar 

  52. Dodd JM, Grivell RM, Crowther CA, Robinson JS (2010) Antenatal interventions for overweight or obese pregnant women: a systematic review of randomised trials. BJOG 117:1316–1326

    Article  CAS  PubMed  Google Scholar 

  53. Dodd JM, Turnbull D, McPhee AJ, Deussen AR, Grivell RM, Yelland LN et al (2014) Antenatal lifestyle advice for women who are overweight or obese: LIMIT randomised trial. BMJ 348:g1285

    Article  PubMed  PubMed Central  Google Scholar 

  54. Dodd JM, McPhee AJ, Turnbull D, Yelland LN, Deussen AR, Grivell RM et al (2014) The effects of antenatal dietary and lifestyle advice for women who are overweight or obese on neonatal health outcomes: the LIMIT randomised trial. BMC Med 12:163

    Article  PubMed  PubMed Central  Google Scholar 

  55. McGowan CA, McAuliffe FM (2010) The influence of maternal glycaemia and dietary glycaemic index on pregnancy outcome in healthy mothers. Br J Nutr 104:153–159

    Article  CAS  PubMed  Google Scholar 

  56. Walsh JM, Mahony R, Byrne J, Foley M, McAuliffe FM (2011) The association of maternal and fetal glucose homeostasis with fetal adiposity and birthweight. Eur J Obstet Gynecol Reprod Biol 159:338–341

    Article  CAS  PubMed  Google Scholar 

  57. Kong AP, Chan RS, Nelson EA, Chan JC (2011) Role of low-glycemic index diet in management of childhood obesity. Obes Rev 12:492–498

    Article  CAS  PubMed  Google Scholar 

  58. Zhang XM, Ding YL (2008) Glycosylated hemoglobin test in gestational abnormal glucose metabolism. Zhong Nan Da Xue Xue Bao Yi Xue Ban 33:85–88

    PubMed  Google Scholar 

  59. Nagalakshmi CS, Santhosh NU, Krishnamurthy N, Chethan C, Shilpashree MK (2016) Role of altered venous blood lactate and HbA1c in women with gestational diabetes mellitus. J Clin Diagn Res 10(12):BC18–BC20

    CAS  PubMed  PubMed Central  Google Scholar 

  60. Roskjaer AB, Andersen JR, Ronneby H, Damm P, Mathiesen ER (2015) Dietary advices on carbohydrate intake for pregnant women with type 1 diabetes. J Matern Fetal Neonatal Med 28:229–233

    Article  CAS  PubMed  Google Scholar 

  61. Burani J, Longo PJ (2006) Low-glycemic index carbohydrates: an effective behavioral change for glycemic control and weight management in patients with type 1 and 2 diabetes. Diabetes Educ 32:78–88

    Article  PubMed  Google Scholar 

  62. McGowan CA, Walsh JM, Byrne J, Curran S, McAuliffe FM (2013) The influence of a low glycemic index dietary intervention on maternal dietary intake, glycemic index and gestational weight gain during pregnancy: a randomized controlled trial. Nutr J 12(1):140

    Article  PubMed  PubMed Central  Google Scholar 

  63. Donnelly JM, Walsh JM, Byrne J, Molloy EJ, McAuliffe FM (2015) Impact of maternal diet on neonatal anthropometry: a randomized controlled trial. Pediatr Obes 10:52–56

    Article  CAS  PubMed  Google Scholar 

  64. Syngelaki A, Nicolaides KH, Balani J, Hyer S, Akolekar R, Kotecha R et al (2016) Metformin versus placebo in obese pregnant women without diabetes mellitus. N Engl J Med 374:434–443

    Google Scholar 

  65. Helland IB, Smith L, Blomen B, Saarem K, Saugstad OD, Drevon CA (2008) Effect of supplementing pregnant and lactating mothers with n-3 very-long-chain fatty acids on children’s IQ and body mass index at 7 years of age. Pediatrics 122(2):e472–e479

    Article  PubMed  Google Scholar 

  66. Deng J, Li X, Ding Z, Wu Y, Chen X, Xie L (2017) Effect of DHA supplements during pregnancy on the concentration of PUFA in breast milk of Chinese lactating mothers. J Perinat Med 45:437–441

    Article  CAS  PubMed  Google Scholar 

  67. Hawkes JS, Bryan DL, Makrides M, Neumann MA, Gibson RA (2002) A randomized trial of supplementation with docosahexaenoic acid-rich tuna oil and its effects on the human milk cytokines interleukin 1 beta, interleukin 6, and tumor necrosis factor alpha. Am J Clin Nutr 75:754–760

    Article  CAS  PubMed  Google Scholar 

  68. Goularte JF, Ferreira MB, Sanvitto GL (2012) Effects of food pattern change and physical exercise on cafeteria diet-induced obesity in female rats. Br J Nutr 108:1511–1518

    Article  CAS  PubMed  Google Scholar 

  69. Zambrano E, Martinez-Samayoa PM, Rodriguez-Gonzalez GL, Nathanielsz PW (2010) Dietary intervention prior to pregnancy reverses metabolic programming in male offspring of obese rats. J Physiol 588:1791–1799

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. Tuersunjiang N, Odhiambo JF, Long NM, Shasa DR, Nathanielsz PW, Ford SP (2013) Diet reduction to requirements in obese/overfed ewes from early gestation prevents glucose/insulin dysregulation and returns fetal adiposity and organ development to control levels. Am J Physiol Endocrinol Metab 305:E868–E878

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  71. Segovia SA, Vickers MH, Gray C, Reynolds CM (2014) Maternal obesity, inflammation, and developmental programming. Biomed Res Int 2014:418975

    Article  PubMed  PubMed Central  Google Scholar 

  72. Kursvietiene L, Staneviciene I, Mongirdiene A, Bernatoniene J (2016) Multiplicity of effects and health benefits of resveratrol. Medicina 52:148–155

    Article  PubMed  Google Scholar 

  73. Zou T, Chen D, Yang Q, Wang B, Zhu MJ, Nathanielsz PW et al (2017) Resveratrol supplementation of high-fat diet-fed pregnant mice promotes brown and beige adipocyte development and prevents obesity in male offspring. J Physiol 595:1547–1562

    Article  CAS  PubMed  Google Scholar 

  74. Roberts VH, Pound LD, Thorn SR, Gillingham MB, Thornburg KL, Friedman JE et al (2014) Beneficial and cautionary outcomes of resveratrol supplementation in pregnant nonhuman primates. FASEB J 28:2466–2477

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  75. Shokryzadan P, Rajion MA, Meng GY, Boo LJ, Ebrahimi M, Royan M et al (2017) Conjugated linoleic acid: a potent fatty acid linked to animal and human health. Crit Rev Food Sci Nutr 57:2737–2748

    Article  CAS  PubMed  Google Scholar 

  76. Segovia SA, Vickers MH, Zhang XD, Gray C, Reynolds CM (2015) Maternal supplementation with conjugated linoleic acid in the setting of diet-induced obesity normalises the inflammatory phenotype in mothers and reverses metabolic dysfunction and impaired insulin sensitivity in offspring. J Nutr Biochem 26:1448–1457

    Article  CAS  PubMed  Google Scholar 

  77. Pileggi CA, Segovia SA, Markworth JF, Gray C, Zhang XD, Milan AM et al (2016) Maternal conjugated linoleic acid supplementation reverses high-fat diet-induced skeletal muscle atrophy and inflammation in adult male rat offspring. Am J Physiol Regul Integr Comp Physiol 310(5):R432–R439

    Article  CAS  PubMed  Google Scholar 

  78. Vickers MH, Sloboda DM (2012) Leptin as mediator of the effects of developmental programming. Best Pract Res Clin Endocrinol Metab 26:677–687

    Article  CAS  PubMed  Google Scholar 

  79. Vickers MH, Gluckman PD, Coveny AH, Hofman PL, Cutfield WS, Gertler A et al (2005) Neonatal leptin treatment reverses developmental programming. Endocrinology 146:4211–4216

    Article  CAS  PubMed  Google Scholar 

  80. Konieczna J, Garcia AP, Sanchez J, Palou M, Palou A, Pico C (2013) Oral leptin treatment in suckling rats ameliorates detrimental effects in hypothalamic structure and function caused by maternal caloric restriction during gestation. PLoS One 8(11):e81906

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  81. Murphy MO, Herald JB, Wills CT, Unfried SG, Cohn DM, Loria AS (2017) Postnatal treatment with metyrapone attenuates the effects of diet-induced obesity in female rats exposed to early-life stress. Am J Physiol Endocrinol Metab 312(2):E98–E108

    Article  PubMed  Google Scholar 

  82. Hashemi A, Villa CR, Comelli EM (2016) Probiotics in early life: a preventative and treatment approach. Food Funct 7:1752–1768

    Article  CAS  PubMed  Google Scholar 

  83. Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B et al (2014) Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol 11:506–514

    Article  PubMed  Google Scholar 

  84. Correia MI, Liboredo JC, Consoli ML (2012) The role of probiotics in gastrointestinal surgery. Nutrition 28:230–234

    Article  PubMed  Google Scholar 

  85. Brantsaeter AL, Myhre R, Haugen M, Myking S, Sengpiel V, Magnus P et al (2011) Intake of probiotic food and risk of preeclampsia in primiparous women: the Norwegian mother and child cohort study. Am J Epidemiol 174:807–815

    Article  PubMed  PubMed Central  Google Scholar 

  86. Asemi Z, Samimi M, Tabassi Z, Naghibi Rad M, Rahimi Foroushani A, Khorammian H et al (2013) Effect of daily consumption of probiotic yoghurt on insulin resistance in pregnant women: a randomized controlled trial. Eur J Clin Nutr 67:71–74

    Article  CAS  PubMed  Google Scholar 

  87. Luoto R, Laitinen K, Nermes M, Isolauri E (2010) Impact of maternal probiotic-supplemented dietary counselling on pregnancy outcome and prenatal and postnatal growth: a double-blind, placebo-controlled study. Br J Nutr 103:1792–1799

    Article  CAS  PubMed  Google Scholar 

  88. Matsumiya Y, Kato N, Watanabe K, Kato H (2002) Molecular epidemiological study of vertical transmission of vaginal Lactobacillus species from mothers to newborn infants in Japanese, by arbitrarily primed polymerase chain reaction. J Infect Chemother 8:43–49

    Article  CAS  PubMed  Google Scholar 

  89. Dominguez-Bello MG, Costello EK, Contreras M, Magris M, Hidalgo G, Fierer N et al (2010) Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci U S A 107:11971–11975

    Google Scholar 

  90. Gajer P, Brotman RM, Bai G, Sakamoto J, Schutte UM, Zhong X et al (2012) Temporal dynamics of the human vaginal microbiota. Sci Transl Med 4:132ra152

    Article  Google Scholar 

  91. Backhed F, Ding H, Wang T, Hooper LV, Koh GY, Nagy A et al (2004) The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A 101:15718–15723

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  92. Cani PD, Delzenne NM (2007) Gut microflora as a target for energy and metabolic homeostasis. Curr Opin Clin Nutr Metab Care 10:729–734

    Article  PubMed  Google Scholar 

  93. Rautava S, Kainonen E, Salminen S, Isolauri E (2012) Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol 130:1355–1360

    Article  CAS  PubMed  Google Scholar 

  94. Agarwal R, Sharma N, Chaudhry R, Deorari A, Paul VK, Gewolb IH et al (2003) Effects of oral Lactobacillus GG on enteric microflora in low-birth-weight neonates. J Pediatr Gastroenterol Nutr 36:397–402

    Article  PubMed  Google Scholar 

  95. Mohan R, Koebnick C, Schildt J, Schmidt S, Mueller M, Possner M et al (2006) Effects of Bifidobacterium lactis Bb12 supplementation on intestinal microbiota of preterm infants: a double-blind, placebo-controlled, randomized study. J Clin Microbiol 44:4025–4031

    Article  PubMed  PubMed Central  Google Scholar 

  96. Gueimonde M, Sakata S, Kalliomaki M, Isolauri E, Benno Y, Salminen S (2006) Effect of maternal consumption of lactobacillus GG on transfer and establishment of fecal bifidobacterial microbiota in neonates. J Pediatr Gastroenterol Nutr 42:166–170

    Article  PubMed  CAS  Google Scholar 

  97. Laitinen K, Poussa T, Isolauri E, Nutrition, Allergy, Mucosal Immunology and Intestinal Microbiota Group (2009) Probiotics and dietary counselling contribute to glucose regulation during and after pregnancy: a randomised controlled trial. Br J Nutr 101:1679–1687

    Article  CAS  PubMed  Google Scholar 

  98. Backhed F, Manchester JK, Semenkovich CF, Gordon JI (2007) Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc Natl Acad Sci U S A 104:979–984

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  99. Kalliomaki M, Kirjavainen P, Eerola E, Kero P, Salminen S, Isolauri E (2001) Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing. J Allergy Clin Immunol 107:129–134

    Article  CAS  PubMed  Google Scholar 

  100. Kalliomaki M, Collado MC, Salminen S, Isolauri E (2008) Early differences in fecal microbiota composition in children may predict overweight. Am J Clin Nutr 87:534–538

    CAS  PubMed  Google Scholar 

  101. Ilmonen J, Isolauri E, Poussa T, Laitinen K (2011) Impact of dietary counselling and probiotic intervention on maternal anthropometric measurements during and after pregnancy: a randomized placebo-controlled trial. Clin Nutr 30:156–164

    Article  PubMed  Google Scholar 

  102. Jafarnejad S, Saremi S, Jafarnejad F, Arab A (2016) Effects of a multispecies probiotic mixture on glycemic control and inflammatory status in women with gestational diabetes: a randomized controlled clinical trial. J Nutr Metab 2016:5190846

    Google Scholar 

  103. Wickens KL, Barthow CA, Murphy R, Abels PR, Maude RM, Stone PR et al (2017) Early pregnancy probiotic supplementation with Lactobacillus rhamnosus HN001 may reduce the prevalence of gestational diabetes mellitus: a randomised controlled trial. Br J Nutr 117:804–813

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  104. Karamali M, Dadkhah F, Sadrkhanlou M, Jamilian M, Ahmadi S, Tajabadi-Ebrahimi M et al (2016) Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 42:234–241

    Article  CAS  PubMed  Google Scholar 

  105. Luoto R, Kalliomaki M, Laitinen K, Isolauri E (2010) The impact of perinatal probiotic intervention on the development of overweight and obesity: follow-up study from birth to 10 years. Int J Obes 34:1531–1537

    Article  CAS  Google Scholar 

  106. Schabussova I, Hufnagl K, Tang ML, Hoflehner E, Wagner A, Loupal G et al (2012) Perinatal maternal administration of Lactobacillus paracasei NCC 2461 prevents allergic inflammation in a mouse model of birch pollen allergy. PLoS One 7(7):e40271

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  107. Blumer N, Sel S, Virna S, Patrascan CC, Zimmermann S, Herz U et al (2007) Perinatal maternal application of Lactobacillus rhamnosus GG suppresses allergic airway inflammation in mouse offspring. Clin Exp Allergy 37:348–357

    Article  CAS  PubMed  Google Scholar 

  108. Garcia-Rodenas CL, Bergonzelli GE, Nutten S, Schumann A, Cherbut C, Turini M et al (2006) Nutritional approach to restore impaired intestinal barrier function and growth after neonatal stress in rats. J Pediatr Gastroenterol Nutr 43:16–24

    Article  PubMed  Google Scholar 

  109. Barouei J, Moussavi M, Hodgson DM (2012) Effect of maternal probiotic intervention on HPA axis, immunity and gut microbiota in a rat model of irritable bowel syndrome. PLoS One 7(10):e46051

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  110. Buddington RK, Williams CH, Kostek BM, Buddington KK, Kullen MJ (2010) Maternal-to-infant transmission of probiotics: concept validation in mice, rats, and pigs. Neonatology 97:250–256

    Article  PubMed  Google Scholar 

  111. Caspersen CJ, Powell KE, Christenson GM (1985) Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. Public Health Rep 100:126–131

    CAS  PubMed  PubMed Central  Google Scholar 

  112. Muktabhant B, Lawrie TA, Lumbiganon P, Laopaiboon M (2015) Diet or exercise, or both, for preventing excessive weight gain in pregnancy. Cochrane Database Syst Rev 6:CD007145

    Google Scholar 

  113. Clapp JF III, Simonian S, Lopez B, Appleby-Wineberg S, Harcar-Sevcik R (1998) The one-year morphometric and neurodevelopmental outcome of the offspring of women who continued to exercise regularly throughout pregnancy. Am J Obstet Gynecol 178:594–599

    Article  PubMed  Google Scholar 

  114. Clapp JF III (2003) The effects of maternal exercise on fetal oxygenation and feto-placental growth. Eur J Obstet Gynecol Reprod Biol 110(Suppl 1):S80–S85

    Article  PubMed  Google Scholar 

  115. May LE, Glaros A, Yeh HW, Clapp JF III, Gustafson KM (2010) Aerobic exercise during pregnancy influences fetal cardiac autonomic control of heart rate and heart rate variability. Early Hum Dev 86:213–217

    Article  PubMed  Google Scholar 

  116. May LE, Scholtz SA, Suminski R, Gustafson KM (2014) Aerobic exercise during pregnancy influences infant heart rate variability at one month of age. Early Hum Dev 90:33–38

    Article  PubMed  Google Scholar 

  117. Cid M, Gonzalez M (2016) Potential benefits of physical activity during pregnancy for the reduction of gestational diabetes prevalence and oxidative stress. Early Hum Dev 94:57–62

    Article  CAS  PubMed  Google Scholar 

  118. Seneviratne SN, McCowan LM, Cutfield WS, Derraik JG, Hofman PL (2015) Exercise in pregnancies complicated by obesity: achieving benefits and overcoming barriers. Am J Obstet Gynecol 212:442–449

    Article  PubMed  Google Scholar 

  119. Clapp JF III, Little KD, Appleby-Wineberg SK, Widness JA (1995) The effect of regular maternal exercise on erythropoietin in cord blood and amniotic fluid. Am J Obstet Gynecol 172:1445–1451

    Article  PubMed  Google Scholar 

  120. Clapp JF III, Stepanchak W, Tomaselli J, Kortan M, Faneslow S (2000) Portal vein blood flow-effects of pregnancy, gravity, and exercise. Am J Obstet Gynecol 183:167–172

    PubMed  Google Scholar 

  121. Kennelly MM, McCaffrey N, McLoughlin P, Lyons S, McKenna P (2002) Fetal heart rate response to strenuous maternal exercise: not a predictor of fetal distress. Am J Obstet Gynecol 187:811–816

    Article  PubMed  Google Scholar 

  122. Clapp JF III, Capeless EL (1990) Neonatal morphometrics after endurance exercise during pregnancy. Am J Obstet Gynecol 163:1805–1811

    Article  PubMed  Google Scholar 

  123. May LE, Suminski RR, Langaker MD, Yeh HW, Gustafson KM (2012) Regular maternal exercise dose and fetal heart outcome. Med Sci Sports Exerc 44:1252–1258

    Article  PubMed  Google Scholar 

  124. Seneviratne SN, Jiang Y, Derraik J, McCowan L, Parry GK, Biggs JB et al (2016) Effects of antenatal exercise in overweight and obese pregnant women on maternal and perinatal outcomes: a randomised controlled trial. BJOG 123:588–597

    Article  CAS  PubMed  Google Scholar 

  125. Sui Z, Grivell RM, Dodd JM (2012) Antenatal exercise to improve outcomes in overweight or obese women: a systematic review. Acta Obstet Gynecol Scand 91(5):538–545

    Article  PubMed  Google Scholar 

  126. Dekker Nitert M, Barrett HL, Denny KJ, McIntyre HD, Callaway LK, BAMBINO group (2015) Exercise in pregnancy does not alter gestational weight gain, MCP-1 or leptin in obese women. Aust N Z J Obstet Gynaecol 55:27–33

    Article  PubMed  Google Scholar 

  127. Mottola MF (2013) Physical activity and maternal obesity: cardiovascular adaptations, exercise recommendations, and pregnancy outcomes. Nutr Rev 71(Suppl 1):S31–S36

    Article  PubMed  Google Scholar 

  128. Choi J, Fukuoka Y, Lee JH (2013) The effects of physical activity and physical activity plus diet interventions on body weight in overweight or obese women who are pregnant or in postpartum: a systematic review and meta-analysis of randomized controlled trials. Prev Med 56:351–364

    Article  PubMed  PubMed Central  Google Scholar 

  129. Wang C, Zhu W, Wei Y, Feng H, Su R, Yang H (2015) Exercise intervention during pregnancy can be used to manage weight gain and improve pregnancy outcomes in women with gestational diabetes mellitus. BMC Pregnancy Childbirth 15:255

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  130. Brekke HK, Bertz F, Rasmussen KM, Bosaeus I, Ellegard L, Winkvist A (2014) Diet and exercise interventions among overweight and obese lactating women: randomized trial of effects on cardiovascular risk factors. PLoS One 9(2):e88250

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  131. Rosa BV, Blair HT, Vickers MH, Dittmer KE, Morel PC, Knight CG et al (2013) Moderate exercise during pregnancy in Wistar rats alters bone and body composition of the adult offspring in a sex-dependent manner. PLoS One 8(12):e82378

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  132. Carter LG, Qi NR, De Cabo R, Pearson KJ (2013) Maternal exercise improves insulin sensitivity in mature rat offspring. Med Sci Sports Exerc 45:832–840

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  133. Camarillo IG, Clah L, Zheng W, Zhou X, Larrick B, Blaize N et al (2014) Maternal exercise during pregnancy reduces risk of mammary tumorigenesis in rat offspring. Eur J Cancer Prev 23:502–505

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  134. Eclarinal JD, Zhu S, Baker MS, Piyarathna DB, Coarfa C, Fiorotto ML et al (2016) Maternal exercise during pregnancy promotes physical activity in adult offspring. FASEB J 30:2541–2548

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  135. Carter LG, Ngo Tenlep SY, Woollett LA, Pearson KJ (2015) Exercise improves glucose disposal and insulin signaling in pregnant mice fed a high fat diet. J Diabetes Metab 6(12)

    Google Scholar 

  136. Laker RC, Lillard TS, Okutsu M, Zhang M, Hoehn KL, Connelly JJ et al (2014) Exercise prevents maternal high-fat diet-induced hypermethylation of the Pgc-1alpha gene and age-dependent metabolic dysfunction in the offspring. Diabetes 63:1605–1611

    Article  CAS  PubMed  Google Scholar 

  137. Vega CC, Reyes-Castro LA, Bautista CJ, Larrea F, Nathanielsz PW, Zambrano E (2015) Exercise in obese female rats has beneficial effects on maternal and male and female offspring metabolism. Int J Obes 39:712–719

    Article  CAS  Google Scholar 

  138. Wen LM, Baur LA, Simpson JM, Rissel C, Wardle K, Flood VM (2012) Effectiveness of home based early intervention on children’s BMI at age 2: randomised controlled trial. BMJ 344:e3732

    Article  PubMed  PubMed Central  Google Scholar 

  139. Williams SJ, Hemmings DG, Mitchell JM, McMillen IC, Davidge ST (2005) Effects of maternal hypoxia or nutrient restriction during pregnancy on endothelial function in adult male rat offspring. J Physiol 565:125–135

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  140. Bahari H, Caruso V, Morris MJ (2013) Late-onset exercise in female rat offspring ameliorates the detrimental metabolic impact of maternal obesity. Endocrinology 154:3610–3621

    Article  CAS  PubMed  Google Scholar 

  141. Rodriguez-Gonzalez GL, Vega CC, Boeck L, Vazquez M, Bautista CJ, Reyes-Castro LA et al (2015) Maternal obesity and overnutrition increase oxidative stress in male rat offspring reproductive system and decrease fertility. Int J Obes 39:549–556

    Article  CAS  Google Scholar 

  142. Santos M, Rodriguez-Gonzalez GL, Ibanez C, Vega CC, Nathanielsz PW, Zambrano E (2015) Adult exercise effects on oxidative stress and reproductive programming in male offspring of obese rats. Am J Physiol Regul Integr Comp Physiol 308:R219–R225

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

Elena Zambrano is supported by the Newton Fund RCUK-CONACyT (Research Councils UK—Consejo Nacional de Ciencia y Tecnología) with the project entitle “Interventions to improve maternal metabolic profile and prevent cardio-metabolic and behavioural deficits in future generations due to programming by maternal obesity.”

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Authors and Affiliations

  1. Reproductive Biology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

    Guadalupe L. Rodríguez-González, Diana C. Castro-Rodríguez & Elena Zambrano

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  1. Guadalupe L. Rodríguez-González
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  2. Diana C. Castro-Rodríguez
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  3. Elena Zambrano
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Correspondence to Elena Zambrano .

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  1. Debden, Essex, United Kingdom

    Paul C. Guest

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Rodríguez-González, G.L., Castro-Rodríguez, D.C., Zambrano, E. (2018). Pregnancy and Lactation: A Window of Opportunity to Improve Individual Health. In: Guest, P. (eds) Investigations of Early Nutrition Effects on Long-Term Health. Methods in Molecular Biology, vol 1735. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7614-0_7

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  • DOI: https://doi.org/10.1007/978-1-4939-7614-0_7

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