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Synthesis of Triangular Silver and Gold Nanoprisms Using Consensus Sequence Tetratricopeptide Repeat Proteins

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Protein Scaffolds

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1798))

Abstract

Anisotropic metallic nanoparticles, such as Au and Ag nanoprisms (NPSMs), have received tremendous attention for their application in catalysis, molecular sensing, signal amplification, bioimaging, and therapeutic applications due to their shape-dependent optical and physical properties. Herein, we present a protein-enabled synthetic strategy for the seeded growth of silver and gold NPSMs with low shape polydispersity, narrow size distribution, and tailored plasmonic absorbance. During the initial seed nucleation step, consensus sequence tetratricopeptide repeat (CTPR) proteins are utilized as potent stabilizers to facilitate the formation of planar-twinned Ag seeds. High yield production of well-defined Ag/Au NPSMs is achieved, respectively, by adding CTPR-stabilized Ag seeds into the growth solutions containing metal precursor, mild reducing agent, sodium halide, and additional CTPR.

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Acknowledgments

The authors would like to thank Dr. Guoliang Liu for insightful comments, suggestions, and discussion on this research work. The authors acknowledge ICTAS Nanoscale Characterization and Fabrication Lab (NCFL) for the use of AFM, TEM, and SEM. This work was in part supported by the JFC ICTAS grant number 119106 to TZG.

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Authors and Affiliations

  1. Department of Chemistry, Virginia Tech, Hahn Hall South, Blacksburg, VA, USA

    Xi Geng & Tijana Z. Grove

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  1. Xi Geng
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  2. Tijana Z. Grove
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Corresponding author

Correspondence to Tijana Z. Grove .

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Editors and Affiliations

  1. Department of Chemistry, Occidental College, Los Angeles, California, USA

    Andrew K. Udit

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Geng, X., Grove, T.Z. (2018). Synthesis of Triangular Silver and Gold Nanoprisms Using Consensus Sequence Tetratricopeptide Repeat Proteins. In: Udit, A. (eds) Protein Scaffolds. Methods in Molecular Biology, vol 1798. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7893-9_11

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  • DOI: https://doi.org/10.1007/978-1-4939-7893-9_11

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7892-2

  • Online ISBN: 978-1-4939-7893-9

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